| WDR18 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | WDR18, Ipi3, R32184_1, WD repeat domain 18 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 2158400; HomoloGene: 32573; GeneCards: WDR18; OMA: WDR18 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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WD repeat domain 18 is a protein that in humans is encoded by the WDR18 gene. [5]
Function
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR18 forms a nucleolar complex with LAS1L, PELP1, TEX10 called the rixosome which is involved in RNA degradation. [6] [7] The rixosome is a nucleolar complex that cofractionates with the 60S preribosomal subunit. Recruitment of the rixosome by the Polycomb Repressive Complex 1 has been proposed to lead to its functioning in establishing repressive chromatin structures by assisting in degrading nascent RNA. [8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000065268 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035754 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: WD repeat domain 18". Retrieved 2017-08-12.
- ^ Castle CD, Cassimere EK, Denicourt C (February 2012). "LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis". Molecular Biology of the Cell. 23 (4): 716–728. doi: 10.1091/mbc.E11-06-0530. PMC 3279398. PMID 22190735.
- ^ Shipkovenska G, Durango A, Kalocsay M, Gygi SP, Moazed D (June 2020). "A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin". eLife. 9. doi: 10.7554/eLife.54341. PMC 7269676. PMID 32491985.
- ^ Zhou H, Stein CB, Shafiq TA, Shipkovenska G, Kalocsay M, Paulo JA, et al. (April 2022). "Rixosomal RNA degradation contributes to silencing of Polycomb target genes". Nature. 604 (7904): 167–174. Bibcode: 2022Natur.604..167Z. doi: 10.1038/s41586-022-04598-0. PMC 8986528. PMID 35355014.
 | This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it. |
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
| WDR18 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | WDR18, Ipi3, R32184_1, WD repeat domain 18 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 2158400; HomoloGene: 32573; GeneCards: WDR18; OMA: WDR18 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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WD repeat domain 18 is a protein that in humans is encoded by the WDR18 gene. [5]
Function
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR18 forms a nucleolar complex with LAS1L, PELP1, TEX10 called the rixosome which is involved in RNA degradation. [6] [7] The rixosome is a nucleolar complex that cofractionates with the 60S preribosomal subunit. Recruitment of the rixosome by the Polycomb Repressive Complex 1 has been proposed to lead to its functioning in establishing repressive chromatin structures by assisting in degrading nascent RNA. [8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000065268 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035754 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: WD repeat domain 18". Retrieved 2017-08-12.
- ^ Castle CD, Cassimere EK, Denicourt C (February 2012). "LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis". Molecular Biology of the Cell. 23 (4): 716–728. doi: 10.1091/mbc.E11-06-0530. PMC 3279398. PMID 22190735.
- ^ Shipkovenska G, Durango A, Kalocsay M, Gygi SP, Moazed D (June 2020). "A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin". eLife. 9. doi: 10.7554/eLife.54341. PMC 7269676. PMID 32491985.
- ^ Zhou H, Stein CB, Shafiq TA, Shipkovenska G, Kalocsay M, Paulo JA, et al. (April 2022). "Rixosomal RNA degradation contributes to silencing of Polycomb target genes". Nature. 604 (7904): 167–174. Bibcode: 2022Natur.604..167Z. doi: 10.1038/s41586-022-04598-0. PMC 8986528. PMID 35355014.
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| This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it. |
This article incorporates text from the United States National Library of Medicine, which is in the public domain.