Prefoldin subunit 3 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | VBP1 | ||||||
NCBI gene | 7411 | ||||||
HGNC | 12662 | ||||||
OMIM | 300133 | ||||||
RefSeq | NM_003372 | ||||||
UniProt | P61758 | ||||||
Other data | |||||||
Locus | Chr. X q28 | ||||||
|
Prefoldin subunit 3 (VBP-1), [1] also Von Hippel–Lindau binding protein 1, is a prefoldin chaperone protein that binds to von Hippel–Lindau protein and transports it from perinuclear granules to the nucleus or cytoplasm inside the cell. [2] It is also involved in transporting nascent polypeptides to cytosolic chaperonins for post-translational folding. [3]
VBP-1 is a 197– amino acid heterohexamer comprising two prefoldin-α and four prefoldin-β subunits, [3] and is a member of the prefoldin-α subunit family. [4] It is ubiquitously expressed in tissues, and is located in the cell nucleus and cytoplasm. [4] The VBP1 gene is located at Xq28. [5] Homologues are known to exist between human VBP-1 and proteins in mice, Drosophila and C. elegans. [3]
Prefoldin subunit 3 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | VBP1 | ||||||
NCBI gene | 7411 | ||||||
HGNC | 12662 | ||||||
OMIM | 300133 | ||||||
RefSeq | NM_003372 | ||||||
UniProt | P61758 | ||||||
Other data | |||||||
Locus | Chr. X q28 | ||||||
|
Prefoldin subunit 3 (VBP-1), [1] also Von Hippel–Lindau binding protein 1, is a prefoldin chaperone protein that binds to von Hippel–Lindau protein and transports it from perinuclear granules to the nucleus or cytoplasm inside the cell. [2] It is also involved in transporting nascent polypeptides to cytosolic chaperonins for post-translational folding. [3]
VBP-1 is a 197– amino acid heterohexamer comprising two prefoldin-α and four prefoldin-β subunits, [3] and is a member of the prefoldin-α subunit family. [4] It is ubiquitously expressed in tissues, and is located in the cell nucleus and cytoplasm. [4] The VBP1 gene is located at Xq28. [5] Homologues are known to exist between human VBP-1 and proteins in mice, Drosophila and C. elegans. [3]