| VIS1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | VIS1, HIS-1, HIS1, viral integration site 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 164755; GeneCards: VIS1; OMA: VIS1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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VIS1 (viral integration site 1), also known as HIS-1, is a long non-coding RNA. It was originally identified in mice in a screen for genes involved in the development of myeloid leukemia. In murine myeloid leukemias, this gene is a common site of viral insertion by the murine ecotropic retrovirus CasBrM [2] [3] It is conserved amongst vertebrates, including human, mice, cats, pigs, cattle and dogs. [4] Expression of VIS1 is restricted to epithelial cells, leukemias and carcinomas. [5]
See also
References
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Askew DS, Bartholomew C, Buchberg AM, et al. (November 1991). "His-1 and His-2: identification and chromosomal mapping of two commonly rearranged sites of viral integration in a myeloid leukemia". Oncogene. 6 (11): 2041–2047. PMID 1682866.
- ^ Askew DS, Li J, Ihle JN (March 1994). "Retroviral insertions in the murine His-1 locus activate the expression of a novel RNA that lacks an extensive open reading frame". Mol. Cell. Biol. 14 (3): 1743–1751. doi: 10.1128/MCB.14.3.1743. PMC 358532. PMID 8114708.
- ^ Li J, Rhodes JC, Askew DS (January 1997). "Evolutionary conservation of putative functional domains in the human homolog of the murine His-1 gene". Gene. 184 (2): 169–176. doi: 10.1016/S0378-1119(96)00591-4. PMID 9031624.
- ^ Li J, Witte DP, Van Dyke T, Askew DS (April 1997). "Expression of the putative proto-oncogene His-1 in normal and neoplastic tissues". Am. J. Pathol. 150 (4): 1297–1305. PMC 1858164. PMID 9094986.
| VIS1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | VIS1, HIS-1, HIS1, viral integration site 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 164755; GeneCards: VIS1; OMA: VIS1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
VIS1 (viral integration site 1), also known as HIS-1, is a long non-coding RNA. It was originally identified in mice in a screen for genes involved in the development of myeloid leukemia. In murine myeloid leukemias, this gene is a common site of viral insertion by the murine ecotropic retrovirus CasBrM [2] [3] It is conserved amongst vertebrates, including human, mice, cats, pigs, cattle and dogs. [4] Expression of VIS1 is restricted to epithelial cells, leukemias and carcinomas. [5]
See also
References
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Askew DS, Bartholomew C, Buchberg AM, et al. (November 1991). "His-1 and His-2: identification and chromosomal mapping of two commonly rearranged sites of viral integration in a myeloid leukemia". Oncogene. 6 (11): 2041–2047. PMID 1682866.
- ^ Askew DS, Li J, Ihle JN (March 1994). "Retroviral insertions in the murine His-1 locus activate the expression of a novel RNA that lacks an extensive open reading frame". Mol. Cell. Biol. 14 (3): 1743–1751. doi: 10.1128/MCB.14.3.1743. PMC 358532. PMID 8114708.
- ^ Li J, Rhodes JC, Askew DS (January 1997). "Evolutionary conservation of putative functional domains in the human homolog of the murine His-1 gene". Gene. 184 (2): 169–176. doi: 10.1016/S0378-1119(96)00591-4. PMID 9031624.
- ^ Li J, Witte DP, Van Dyke T, Askew DS (April 1997). "Expression of the putative proto-oncogene His-1 in normal and neoplastic tissues". Am. J. Pathol. 150 (4): 1297–1305. PMC 1858164. PMID 9094986.