From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Guanine nucleotide exchange factor VAV3 is a
protein that in humans is encoded by the VAV3
gene .
[5]
This gene is a member of the VAV gene family. The
VAV proteins are
guanine nucleotide exchange factors (GEFs) for
Rho family GTPases that activate pathways leading to
actin cytoskeletal rearrangements and
transcriptional alterations. This gene product acts as a GEF preferentially for
RhoG ,
RhoA , and to a lesser extent,
RAC1 , and it associates maximally with the nucleotide-free states of these GTPases.
Alternatively spliced transcript variants encoding different
isoforms have been described for this gene.
[5]
Interactions
VAV3 has been shown to
interact with
Grb2 .
[6]
[7]
See also
References
Further reading
Hobert O, Schilling JW, Beckerle MC, et al. (1996). "SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin". Oncogene . 12 (7): 1577–81.
PMID
8622875 .
Tamma SM, Chirmule N, Yagura H, et al. (1997).
"CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells" . Blood . 90 (4): 1588–93.
doi :
10.1182/blood.V90.4.1588 .
PMID
9269777 .
Trenkle T, Welsh J, Jung B, et al. (1998).
"Non-stoichiometric reduced complexity probes for cDNA arrays" . Nucleic Acids Res . 26 (17): 3883–3891.
doi :
10.1093/nar/26.17.3883 .
PMC
147802 .
PMID
9705494 .
Movilla N, Bustelo XR (1999).
"Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins" . Mol. Cell. Biol . 19 (11): 7870–85.
doi :
10.1128/mcb.19.11.7870 .
PMC
84867 .
PMID
10523675 .
Trenkle T, McClelland M, Adlkofer K, Welsh J (2000). "Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors". Gene . 245 (1): 139–149.
doi :
10.1016/S0378-1119(00)00026-3 .
PMID
10713454 .
Zeng L, Sachdev P, Yan L, et al. (2001).
"Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation" . Mol. Cell. Biol . 20 (24): 9212–9224.
doi :
10.1128/MCB.20.24.9212-9224.2000 .
PMC
102179 .
PMID
11094073 .
Inabe K, Ishiai M, Scharenberg AM, et al. (2002).
"Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation" . J. Exp. Med . 195 (2): 189–200.
doi :
10.1084/jem.20011571 .
PMC
2193613 .
PMID
11805146 .
Yabana N, Shibuya M (2002).
"Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity" . Oncogene . 21 (50): 7720–7729.
doi :
10.1038/sj.onc.1205927 .
PMID
12400014 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–45.
doi :
10.1038/ng1285 .
PMID
14702039 .
Zakaria S, Gomez TS, Savoy DN, et al. (2004).
"Differential regulation of TCR-mediated gene transcription by Vav family members" . J. Exp. Med . 199 (3): 429–434.
doi :
10.1084/jem.20031228 .
PMC
2211790 .
PMID
14757747 .
Pearce AC, Senis YA, Billadeau DD, et al. (2005).
"Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen" . J. Biol. Chem . 279 (52): 53955–53962.
doi :
10.1074/jbc.M410355200 .
PMID
15456756 .
Charvet C, Canonigo AJ, Billadeau DD, Altman A (2005).
"Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76" . J. Biol. Chem . 280 (15): 15289–15299.
doi :
10.1074/jbc.M500275200 .
PMID
15708849 .
Lyons LS, Burnstein KL (2006).
"Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity" . Mol. Endocrinol . 20 (5): 1061–1072.
doi :
10.1210/me.2005-0346 .
PMID
16384856 .
S2CID
43049417 .
Dong Z, Liu Y, Lu S, et al. (2006).
"Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer" . Mol. Endocrinol . 20 (10): 2315–2325.
doi :
10.1210/me.2006-0048 .
PMID
16762975 .