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Marfan syndrome
Marfan syndrome is a connective tissue disorder. Connective tissue is responsible for supporting and connecting many of the body's structures. Fibrillin-1 protein forms fibers in connective tissue I n a d dition to p r o v i d i n g s t r u c t u r a l s u p p o r t , t h e n o r m a l f i b r i l l i n - 1 p r o t e i n a l s o c o n t r i b u t e s t o c e l l s i g n a l i n g a c t i v i t y , b i n d i n g t o t h e p r o t e i n t r a n s f o r m i n g g r o w t h f a c t o r b e t a ( T G F - ≤ ) . M i s - r e g u l a t e d T G F - ≤ h a s d e l e t e r i o u s e f f e c t s o n v a s c u l a r s m o o t h m u s c l e d e v e l o p m e n t a n d t h e i n t e g r i t y o f t h e e x t r a c e l l u l a r m a t r i x . R e s e a r c h e r s n o w b e l i e v e , s e c o n d a r y t o m u t a t e d s t r u c t u r a l f i b r i l l i n , e x c e s s i v e T G F - ≤ a t t h e l u n g s , h e a r t v a l v e s , a n d a o r t a w e a k e n s t h e t i s s u e s a n d c a u s e s t h e f e a t u r e s o f M a r f a n s y n d r o m e . S i n c e a n g i o t e n s i n I I r e c e p t o r a n t a g o n i s t s ( A R B s ) a l s o r e d u c e T G F - ≤ , A R B s ( s u c h a s l o s a r t a n ) h a v e b e e n t e s t e d i n a s m a l l s a m p l e o f y o u n g , s e v e r e l y a f f e c t e d p e o p l e w i t h M a r f a n s y n d r o m e . I n s o m e , t h e g r o w t h o f t h e a o r t a w a s r e d u c e d . [ 3 ] ( http://en.wikipedia.org/wiki/Marfan_syndrome).
Sings and Symptoms Symptoms of Marfan syndrome vary from mild to severe. Marfan syndrome can affect one or many parts of the body. Symptoms of Marfan syndrome can express itself at a young age. Alternatively, Marfan syndrome may also express itself later in life. There are some symptoms may worsen with age. There are several symptoms that are consistent across the board. These are telling tale signs that are clear indicators of Marfan syndrome ( http://ebsco.smartimagebase.com/marfan-syndrome/view-item?ItemID=62360).
( http://ebsco.smartimagebase.com/marfan-syndrome/view-item?ItemID=62360).
Cite error: There are <ref>
tags on this page without content in them (see the
help page).Original text from Marfan Syndrome via Wikipedia
Marfan syndrome
Marfan syndrome is a connective tissue disorder. Connective tissue is responsible for supporting and connecting many of the body's structures. Fibrillin-1 protein forms fibers in connective tissue I n a d dition to p r o v i d i n g s t r u c t u r a l s u p p o r t , t h e n o r m a l f i b r i l l i n - 1 p r o t e i n a l s o c o n t r i b u t e s t o c e l l s i g n a l i n g a c t i v i t y , b i n d i n g t o t h e p r o t e i n t r a n s f o r m i n g g r o w t h f a c t o r b e t a ( T G F - ≤ ) . M i s - r e g u l a t e d T G F - ≤ h a s d e l e t e r i o u s e f f e c t s o n v a s c u l a r s m o o t h m u s c l e d e v e l o p m e n t a n d t h e i n t e g r i t y o f t h e e x t r a c e l l u l a r m a t r i x . R e s e a r c h e r s n o w b e l i e v e , s e c o n d a r y t o m u t a t e d s t r u c t u r a l f i b r i l l i n , e x c e s s i v e T G F - ≤ a t t h e l u n g s , h e a r t v a l v e s , a n d a o r t a w e a k e n s t h e t i s s u e s a n d c a u s e s t h e f e a t u r e s o f M a r f a n s y n d r o m e . S i n c e a n g i o t e n s i n I I r e c e p t o r a n t a g o n i s t s ( A R B s ) a l s o r e d u c e T G F - ≤ , A R B s ( s u c h a s l o s a r t a n ) h a v e b e e n t e s t e d i n a s m a l l s a m p l e o f y o u n g , s e v e r e l y a f f e c t e d p e o p l e w i t h M a r f a n s y n d r o m e . I n s o m e , t h e g r o w t h o f t h e a o r t a w a s r e d u c e d . [ 3 ] ( http://en.wikipedia.org/wiki/Marfan_syndrome).
Sings and Symptoms Symptoms of Marfan syndrome vary from mild to severe. Marfan syndrome can affect one or many parts of the body. Symptoms of Marfan syndrome can express itself at a young age. Alternatively, Marfan syndrome may also express itself later in life. There are some symptoms may worsen with age. There are several symptoms that are consistent across the board. These are telling tale signs that are clear indicators of Marfan syndrome ( http://ebsco.smartimagebase.com/marfan-syndrome/view-item?ItemID=62360).
( http://ebsco.smartimagebase.com/marfan-syndrome/view-item?ItemID=62360).