TEX36 Information
TEX36, testes expressed 36, is a protein that in humans is encoded by the tex36 gene. The encoded protein is highly expressed in fetal and placental tissue suggesting that it is involved in development.
Gene
Locus
Common Aliases
Size of gene, number of exons (not mRNA)
Testes expressed 36, also known as C10orf122 or BA383C5.1 is a protein encoding gene. [1] This protein has yet to have a known function. The verified gene sequence was confirmed in NCBI on November 26, 2016. It has cytogenetic bands at 10q26.13. TEX36 is also a member of the Human CCDS set CCDS44493.1. [2]
The protein is encoded by 4 exons. There are two variants of testes expressed sequence 36 protein, 1 and 2. Variants 1 and 2 both contain 4 exons, but isoform 1 has the longer transcript with an alternately spliced 4 exons, than variant 2 consists of 129 amino acids, with a different terminating region.
mRNA
isoforms/alt splicing (from NCBI gene)
Protein
Primary sequence & variants/isoforms
molecular weights, pI, compositional features
domains and motifs
secondary structure
tertiary and quaternary structure
post-translational modifications
subcellular localization
The protein coded by TEX36, commonly referred to as testes expressed sequence 36 protein, has a mass of 21,545 Da and is composed of 186 amino acids. [1] The protein interacts with PPP1CC, protein phosphatase 1 catalytic subunit, gamma isozyme based on a Two Hybrid screen, and IRF3, interferon regulatory factor 3 based on an Affinity capture-MS. [3]
Expression
DNA to variety of mRAN variants, variety of protein isoforms
Tissue expression pattern (NCBI GEO data)
Expression level
Regulation of Expression
epigenetic
transcription -- promoter, TF that might bind to regulatory sequence
Post-transcription -- transcript variants (alt. splicing regulation)
Translational and mRNA stability -- stem loops in mRNA near AUG, stem loops in 3'UTR, miRNA targets
Protein level - ubiquitination, glycation
Function
Interacting Proteins
Proteins found in Y2H screens, developmental; functional; FULL names
Clinical Significance
Pathology
Disease Association
Variants
TEX36 is one of 77 proteins expressed by testes capable of interacting with PP1, human testis protein protein phosphatase 1. [4] One variant of TEX36, p.R142H, was found across all patients in a study on intracranial aneurysms. However, there was no further research on the gene and its protein function. [5] TEX36 has also been found to be a commonly downregulated gene in patients with microalbuminuria compared to those with normoalbuminuria. [6] Because of the variant associated with intracranial aneurysms and its downregulation associated with various albumin levels, protein changes in TEX36 either in variants or expression levels could be deleterious, but there is no confirmation on these assumptions. [7]
Homology
Paralogs
Ortholog Space
There are many species that have an ortholog of TEX36, these include: mammals, birds, reptiles, amphibians, fish, echinoids, anthozoans, and mollusks. There are no confirmed orthologs in bacteria, fungi/metazoans, plants, or archaea.
Distant homologs
Homologous domains
Phylogeny
Citations
- ^ a b GeneCards, Human Gene Database, entry on TEX36, [http://www.genecards.org/cgi-bin/carddisp.pl?gene=TEX36]
- ^ Ensembl entry on Gene: TEX36, [http://useast.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000175018;r=10:125576522-125683144]
- ^ BioGRID3.4 Result Summary on TEX36, [https://thebiogrid.org/132412]
- ^ Fardilha, M., Esteves, S. L., Korrodi-Gregório, L., Vintém, A. P., Domingues, S. C., Rebelo, S., ... & e Silva, E. F. D. C. (2011). Identification of the human testis protein phosphatase 1 interactome. Biochemical pharmacology, 82(10), 1403-1415.
- ^ Yan, J., Hitomi, T., Takenaka, K., Kato, M., Kobayashi, H., Okuda, H., ... & Koizumi, A. (2015). Genetic study of intracranial aneurysms. Stroke, STROKEAHA-114.
- ^ Lokman, F. E., Seman, N. A., al-Safi Ismail, A., Azwany Yaacob, N., Mustafa, N., Khir, A. S., ... & Wan Mohamud, W. N. (2011). Gene expression profiling in ethnic Malays with type 2 diabetes mellitus, with and without diabetic nephropathy. Journal of nephrology, 24(6), 778.
- ^ Hitchcock, E., & Gibson, W. T. (2016). A Review of the Genetics of Intracranial Berry Aneurysms and Implications for Genetic Counseling. Journal of Genetic Counseling, 1-11.
TEX36 Information
TEX36, testes expressed 36, is a protein that in humans is encoded by the tex36 gene. The encoded protein is highly expressed in fetal and placental tissue suggesting that it is involved in development.
Gene
Locus
Common Aliases
Size of gene, number of exons (not mRNA)
Testes expressed 36, also known as C10orf122 or BA383C5.1 is a protein encoding gene. [1] This protein has yet to have a known function. The verified gene sequence was confirmed in NCBI on November 26, 2016. It has cytogenetic bands at 10q26.13. TEX36 is also a member of the Human CCDS set CCDS44493.1. [2]
The protein is encoded by 4 exons. There are two variants of testes expressed sequence 36 protein, 1 and 2. Variants 1 and 2 both contain 4 exons, but isoform 1 has the longer transcript with an alternately spliced 4 exons, than variant 2 consists of 129 amino acids, with a different terminating region.
mRNA
isoforms/alt splicing (from NCBI gene)
Protein
Primary sequence & variants/isoforms
molecular weights, pI, compositional features
domains and motifs
secondary structure
tertiary and quaternary structure
post-translational modifications
subcellular localization
The protein coded by TEX36, commonly referred to as testes expressed sequence 36 protein, has a mass of 21,545 Da and is composed of 186 amino acids. [1] The protein interacts with PPP1CC, protein phosphatase 1 catalytic subunit, gamma isozyme based on a Two Hybrid screen, and IRF3, interferon regulatory factor 3 based on an Affinity capture-MS. [3]
Expression
DNA to variety of mRAN variants, variety of protein isoforms
Tissue expression pattern (NCBI GEO data)
Expression level
Regulation of Expression
epigenetic
transcription -- promoter, TF that might bind to regulatory sequence
Post-transcription -- transcript variants (alt. splicing regulation)
Translational and mRNA stability -- stem loops in mRNA near AUG, stem loops in 3'UTR, miRNA targets
Protein level - ubiquitination, glycation
Function
Interacting Proteins
Proteins found in Y2H screens, developmental; functional; FULL names
Clinical Significance
Pathology
Disease Association
Variants
TEX36 is one of 77 proteins expressed by testes capable of interacting with PP1, human testis protein protein phosphatase 1. [4] One variant of TEX36, p.R142H, was found across all patients in a study on intracranial aneurysms. However, there was no further research on the gene and its protein function. [5] TEX36 has also been found to be a commonly downregulated gene in patients with microalbuminuria compared to those with normoalbuminuria. [6] Because of the variant associated with intracranial aneurysms and its downregulation associated with various albumin levels, protein changes in TEX36 either in variants or expression levels could be deleterious, but there is no confirmation on these assumptions. [7]
Homology
Paralogs
Ortholog Space
There are many species that have an ortholog of TEX36, these include: mammals, birds, reptiles, amphibians, fish, echinoids, anthozoans, and mollusks. There are no confirmed orthologs in bacteria, fungi/metazoans, plants, or archaea.
Distant homologs
Homologous domains
Phylogeny
Citations
- ^ a b GeneCards, Human Gene Database, entry on TEX36, [http://www.genecards.org/cgi-bin/carddisp.pl?gene=TEX36]
- ^ Ensembl entry on Gene: TEX36, [http://useast.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000175018;r=10:125576522-125683144]
- ^ BioGRID3.4 Result Summary on TEX36, [https://thebiogrid.org/132412]
- ^ Fardilha, M., Esteves, S. L., Korrodi-Gregório, L., Vintém, A. P., Domingues, S. C., Rebelo, S., ... & e Silva, E. F. D. C. (2011). Identification of the human testis protein phosphatase 1 interactome. Biochemical pharmacology, 82(10), 1403-1415.
- ^ Yan, J., Hitomi, T., Takenaka, K., Kato, M., Kobayashi, H., Okuda, H., ... & Koizumi, A. (2015). Genetic study of intracranial aneurysms. Stroke, STROKEAHA-114.
- ^ Lokman, F. E., Seman, N. A., al-Safi Ismail, A., Azwany Yaacob, N., Mustafa, N., Khir, A. S., ... & Wan Mohamud, W. N. (2011). Gene expression profiling in ethnic Malays with type 2 diabetes mellitus, with and without diabetic nephropathy. Journal of nephrology, 24(6), 778.
- ^ Hitchcock, E., & Gibson, W. T. (2016). A Review of the Genetics of Intracranial Berry Aneurysms and Implications for Genetic Counseling. Journal of Genetic Counseling, 1-11.