- Carroll Dale (Class of 1960) - Former wide receiver, All-American, played for Vince Lombardi-era Green Bay Packers
- Frank Loria, First Team All-American safety for VT (1967), First Team Academic All-American (1967), College Football Hall of Fame Member (1999), was offensive coordinator for Marshall (age 23) when he (and team) was killed in plane crash (1970).
- Frank Beamer (Class of 1969) - Head coach of the Virginia Tech football team
- Bruce Smith (Class of 1985) - Defensive linesman for the Buffalo Bills and he Washington Redskins, All-American and first overall pick at the 1985 NFL Draft, 2009 NFL Hall of Fame inductee
- Antonio Freeman (Class of 1995) - Former wide receiver for the Green Bay Packers, played in Super Bowl XXXI, Super Bowl XXXII, and 1998 Pro Bowl
- Jim Druckenmiller (Class of 1996) - Former quarterback for the San Francisco 49ers and Miami Dolphins, 26th pick in the 1997 NFL Draft.
- Ken Oxendine (Class of 1998) - running back for the Atlanta Falcons.
- Shayne Graham (Class of 2000) - NFL place-kicker
- Michael Vick (Class of 2002) - Quarterback for the Philadelphia Eagles, first overall pick at the 2001 NFL Draft. (Did not graduate)
- André Davis (Class of 2002) - wide receiver for the Houston Texans
- Kevin Jones, running back for the Chicago Bears, 1st Round, 30th overall pick at the 2004 NFL Draft
- Jake Grove (Class of 2004) - Center for the Miami Dolphins, All-American 2nd round draft pick in 2004 NFL Draft.
- Ernest Wilford, wide receiver for the Miami Dolphins, selected with the 24th pick of the 4th round in the 2004 NFL Draft.
- Vincent Fuller, safety for the Tennessee Titans, 108th pick in the 2005 NFL Draft.
- DeAngelo Hall (Class of 2005) defensive back for the Washington Redskins, 8th overall pick at the 2004 NFL Draft and played in consecutive Pro-Bowls in 2006–2007. (Did not graduate)
- Jonathan Lewis (Class of 2006) - Defensive Tackle for the Jacksonville Jaguars, selected with the 177th overall pick in the 2006 NFL Draft.
- Darryl Tapp, defensive end for the Philadelphia Eagles, 63rd overall pick at the 2006 NFL Draft
- Aaron Rouse (Class of 2007) - Safety for the New York Giants
- Eddie Royal, wide receiver for the Denver Broncos, selected with the 42nd overall pick in the 2008 NFL Draft.
- Jason Worilds (Class of 2010) - Outside Linebacker for the Pittsburgh Steelers, selected with 52nd overall pick in the 2010 NFL Draft
- Tyrod Taylor (Class of 2011) - Quarterback for the Baltimore Ravens
- David Wilson (Class of 2012) - Running back for the New York Giants, 1st Round pick at the 2012 NFL Draft. (Did not graduate)
- Kyle Fuller (Class of 2014) - Cornerback for the Chicago Bears,14th pick of the 2014 NFL Draft.
- Logan Thomas (Class of 2014) - Quarterback for the Arizona Cardinals.
- Antone Exum (Class of 2014) - Cornerback for the Minnesota Vikings.
- Don Strock, quarterback for Miami Dolphins and Cleveland Browns; later a college head coach
- James Anderson, linebacker for the Chicago Bears
- David Clowney, wide receiver for the New York Jets
- Ryan Williams, running back for the Arizona Cardinals
- Kam Chancellor, safety for the Seattle Seahawks
- Rashad Carmichael, cornerback for the Houston Texans
- John Engelberger, former defensive end for the Denver Broncos
- Vaughn Hebron, running back/kick returner for the Denver Broncos played in Super Bowl XXXII (against Green Bay Packer Antonio Freeman), Super Bowl XXXIII, and is a 2-time Pro Bowler [1]
- Jeff King, tight end for the Carolina Panthers
- Josh Morgan, wide receiver for the Washington Redskins.
- Brandon Flowers, defensive back for the Kansas City Chiefs, selected with the 35th overall pick in the 2008 NFL Draft.
- Michel Faulkner, All-American at Virginia Tech, played for New York Jets in 1981–1982
- Bill Ellenbogen, offensive lineman for the New York Giants.
- Bruce Arians, Head Football Coach, Arizona Cardinals
- Jayron Hosley, Cornerback for the New York Giants.
- Carroll Dale (Class of 1960) - Former wide receiver, All-American, played for Vince Lombardi-era Green Bay Packers
- Frank Loria, First Team All-American safety for VT (1967), First Team Academic All-American (1967), College Football Hall of Fame Member (1999), was offensive coordinator for Marshall (age 23) when he (and team) was killed in plane crash (1970).
- Frank Beamer (Class of 1969) - Head coach of the Virginia Tech football team
- Bruce Smith (Class of 1985) - Defensive linesman for the Buffalo Bills and he Washington Redskins, All-American and first overall pick at the 1985 NFL Draft, 2009 NFL Hall of Fame inductee
- Antonio Freeman (Class of 1995) - Former wide receiver for the Green Bay Packers, played in Super Bowl XXXI, Super Bowl XXXII, and 1998 Pro Bowl
- Jim Druckenmiller (Class of 1996) - Former quarterback for the San Francisco 49ers and Miami Dolphins, 26th pick in the 1997 NFL Draft.
- Ken Oxendine (Class of 1998) - running back for the Atlanta Falcons.
- Shayne Graham (Class of 2000) - NFL place-kicker
- Michael Vick (Class of 2002) - Quarterback for the Philadelphia Eagles, first overall pick at the 2001 NFL Draft. (Did not graduate)
- André Davis (Class of 2002) - wide receiver for the Houston Texans
- Kevin Jones, running back for the Chicago Bears, 1st Round, 30th overall pick at the 2004 NFL Draft
- Jake Grove (Class of 2004) - Center for the Miami Dolphins, All-American 2nd round draft pick in 2004 NFL Draft.
- Ernest Wilford, wide receiver for the Miami Dolphins, selected with the 24th pick of the 4th round in the 2004 NFL Draft.
- Vincent Fuller, safety for the Tennessee Titans, 108th pick in the 2005 NFL Draft.
- DeAngelo Hall (Class of 2005) defensive back for the Washington Redskins, 8th overall pick at the 2004 NFL Draft and played in consecutive Pro-Bowls in 2006–2007. (Did not graduate)
- Jonathan Lewis (Class of 2006) - Defensive Tackle for the Jacksonville Jaguars, selected with the 177th overall pick in the 2006 NFL Draft.
- Darryl Tapp, defensive end for the Philadelphia Eagles, 63rd overall pick at the 2006 NFL Draft
- Aaron Rouse (Class of 2007) - Safety for the New York Giants
- Eddie Royal, wide receiver for the Denver Broncos, selected with the 42nd overall pick in the 2008 NFL Draft.
- Jason Worilds (Class of 2010) - Outside Linebacker for the Pittsburgh Steelers, selected with 52nd overall pick in the 2010 NFL Draft
- Tyrod Taylor (Class of 2011) - Quarterback for the Baltimore Ravens
- David Wilson (Class of 2012) - Running back for the New York Giants, 1st Round pick at the 2012 NFL Draft. (Did not graduate)
- Kyle Fuller (Class of 2014) - Cornerback for the Chicago Bears,14th pick of the 2014 NFL Draft.
- Logan Thomas (Class of 2014) - Quarterback for the Arizona Cardinals.
- Antone Exum (Class of 2014) - Cornerback for the Minnesota Vikings.
- Don Strock, quarterback for Miami Dolphins and Cleveland Browns; later a college head coach
- James Anderson, linebacker for the Chicago Bears
- David Clowney, wide receiver for the New York Jets
- Ryan Williams, running back for the Arizona Cardinals
- Kam Chancellor, safety for the Seattle Seahawks
- Rashad Carmichael, cornerback for the Houston Texans
- John Engelberger, former defensive end for the Denver Broncos
- Vaughn Hebron, running back/kick returner for the Denver Broncos played in Super Bowl XXXII (against Green Bay Packer Antonio Freeman), Super Bowl XXXIII, and is a 2-time Pro Bowler [1]
- Jeff King, tight end for the Carolina Panthers
- Josh Morgan, wide receiver for the Washington Redskins.
- Brandon Flowers, defensive back for the Kansas City Chiefs, selected with the 35th overall pick in the 2008 NFL Draft.
- Michel Faulkner, All-American at Virginia Tech, played for New York Jets in 1981–1982
- Bill Ellenbogen, offensive lineman for the New York Giants.
- Bruce Arians, Head Football Coach, Arizona Cardinals
- Jayron Hosley, Cornerback for the New York Giants.