I propose to make the following changes. Underlined sentences, with their respective references, are from the current Chemotherapy and Immunotherapy subsection of the Melanoma Wikipedia page.
Small-Molecule Targeted Therapies
Melanoma cells have mutations that allow them to survive and grow indefinitely in the body. [1] Small-molecule targeted therapies work by blocking the genes involved pathways for tumor proliferation and survival. [1] The main treatments are BRAF, C-Kit and NRAS inhibitors. [2] These inhibitors work to inhibit the downstream pathways involved in cell proliferation and tumour development due to specific gene mutations. [3] People can be treated with small-molecule targeted inhibitors if they are positive for the specific mutation. [1] BRAF inhibitors, such as vemurafenib and dabrafenib and a MEK inhibitor trametinib are the most effective, approved treatments for BRAF positive melanoma. [4] [1] Melanoma tumors can develop resistance during therapy which can make therapy no longer effective, but combining the use of BRAF and MEK inhibitors may create a fast and lasting melanoma therapy response. [5]
A number of treatments improve survival over traditional chemotherapy. [1] Biochemotherapy (chemotherapy with cytokines IL-2 and IFN-α) combined with BRAF inhibitors improved survival for people with BRAF positive melanoma. [1] Biochemotherapy alone did not improve overall survival and had higher toxicity than chemotherapy but the toxicity of BRAF inhibitors was not significantly different than chemotherapy. [1]
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Thanks for sharing your proposed changes. JenOttawa ( talk) 21:20, 5 November 2018 (UTC)
Great works so far! JenOttawa ( talk) 17:39, 6 November 2018 (UTC)
I propose to make the following changes. Underlined sentences, with their respective references, are from the current Chemotherapy and Immunotherapy subsection of the Melanoma Wikipedia page.
Small-Molecule Targeted Therapies
Melanoma cells have mutations that allow them to survive and grow indefinitely in the body. [1] Small-molecule targeted therapies work by blocking the genes involved pathways for tumor proliferation and survival. [1] The main treatments are BRAF, C-Kit and NRAS inhibitors. [2] These inhibitors work to inhibit the downstream pathways involved in cell proliferation and tumour development due to specific gene mutations. [3] People can be treated with small-molecule targeted inhibitors if they are positive for the specific mutation. [1] BRAF inhibitors, such as vemurafenib and dabrafenib and a MEK inhibitor trametinib are the most effective, approved treatments for BRAF positive melanoma. [4] [1] Melanoma tumors can develop resistance during therapy which can make therapy no longer effective, but combining the use of BRAF and MEK inhibitors may create a fast and lasting melanoma therapy response. [5]
A number of treatments improve survival over traditional chemotherapy. [1] Biochemotherapy (chemotherapy with cytokines IL-2 and IFN-α) combined with BRAF inhibitors improved survival for people with BRAF positive melanoma. [1] Biochemotherapy alone did not improve overall survival and had higher toxicity than chemotherapy but the toxicity of BRAF inhibitors was not significantly different than chemotherapy. [1]
{{
cite journal}}
: CS1 maint: PMC format (
link)
{{
cite journal}}
: Check date values in: |date=
(
help)
Thanks for sharing your proposed changes. JenOttawa ( talk) 21:20, 5 November 2018 (UTC)
Great works so far! JenOttawa ( talk) 17:39, 6 November 2018 (UTC)