The Ski complex is a multi-
protein complex involved in the
3' end degradation of
messenger RNAs in yeast.
[1] The complex consists of three main
proteins, the RNA
helicase Ski2 and the proteins Ski3 and Ski8. This tetramer contains a 370 kDa core complex, containing N-terminal arms and C-terminal arms from Ski3. The helicase core of Ski2 is positioned by both the C-terminal of Ski3 and two subunits of Ski8. Helicase activities are initiated by the N-terminal arm and the Ski2 insertion domain.Cite error: A <ref>
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(see the
help page). In yeast, the complex guides RNA molecules to the
exosome complex for degradation via a fourth protein, called Ski7, which contains a
GTPase-like protein.
[2] Ski7 involves the 3’ to 5’ degradation of RNA through two different pathways, 3’ poly(A) tail shortening and the binding of the Ski2, Ski3, and Ski8 tetramer and the exosome.
[3] The complex consists of three main
proteins, the RNA
helicase Ski2 and the proteins Ski3 and Ski8. This tetramer contains a 370 kDa core complex, containing N-terminal arms and C-terminal arms from Ski3. The helicase core of Ski2 is positioned by both the C-terminal of Ski3 and two subunits of Ski8. Helicase activities are initiated by the N-terminal arm and the Ski2 insertion domain.
[4] Biochemical studies also show that the Ski complex can thread
RNA through the exosome complex, thereby coupling the Ski2 protein helicase function with the exoribonuclease activity, leading to degradation of the
RNA strand.
[5]
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Category:Protein complexes Category:Gene expression Category:Saccharomyces cerevisiae genes
The Ski complex is a multi-
protein complex involved in the
3' end degradation of
messenger RNAs in yeast.
[1] The complex consists of three main
proteins, the RNA
helicase Ski2 and the proteins Ski3 and Ski8. This tetramer contains a 370 kDa core complex, containing N-terminal arms and C-terminal arms from Ski3. The helicase core of Ski2 is positioned by both the C-terminal of Ski3 and two subunits of Ski8. Helicase activities are initiated by the N-terminal arm and the Ski2 insertion domain.Cite error: A <ref>
tag is missing the closing </ref>
(see the
help page). In yeast, the complex guides RNA molecules to the
exosome complex for degradation via a fourth protein, called Ski7, which contains a
GTPase-like protein.
[2] Ski7 involves the 3’ to 5’ degradation of RNA through two different pathways, 3’ poly(A) tail shortening and the binding of the Ski2, Ski3, and Ski8 tetramer and the exosome.
[3] The complex consists of three main
proteins, the RNA
helicase Ski2 and the proteins Ski3 and Ski8. This tetramer contains a 370 kDa core complex, containing N-terminal arms and C-terminal arms from Ski3. The helicase core of Ski2 is positioned by both the C-terminal of Ski3 and two subunits of Ski8. Helicase activities are initiated by the N-terminal arm and the Ski2 insertion domain.
[4] Biochemical studies also show that the Ski complex can thread
RNA through the exosome complex, thereby coupling the Ski2 protein helicase function with the exoribonuclease activity, leading to degradation of the
RNA strand.
[5]
{{
cite journal}}
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value (
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{{
cite journal}}
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Category:Protein complexes Category:Gene expression Category:Saccharomyces cerevisiae genes