The current Wikipedia page has a basic definition, mentions regulation with the polyA tail, and describes some regulatory sequences. These include a polyA signal, binding sites for proteins, and binding sites for micoRNAs. It has around 3 short paragraphs. This information will help us start, and we will expand upon it.
The talk page requested a clear, general definition at the beginning for someone who knows nothing about 3’ utr’s
history: when was it discovered? What did previous scientists think of its function?
physical: how the mechanism works (looping), how long the 3’ UTR is in different organisms, any patterns within it?
most common UTRs
types of regulation of 3’utr in different organisms
example: progenitors, 3’ UTRs inhibit the production of meiotic and oocyte proteins by post-transcriptional mechanisms involving two classes of RNA-binding proteins
microRNA regulation and polyA tail signal, relating to 3’ UTR and translational regulation– this is already mentioned in the wiki page
example study: human single nucleotide polymorphisms (SNPs) on both seed target region and the rest of 3′UTRs of miRNA target genes were under significantly stronger negative selection, when compared to non-miRNA target genes.
biology techniques used to study it in the past
current research
Dividing up the work:
Bryce: types of regulation, biology techniques
Michael: history, physical characteristics, most common UTRs, general definition
The current Wikipedia page has a basic definition, mentions regulation with the polyA tail, and describes some regulatory sequences. These include a polyA signal, binding sites for proteins, and binding sites for micoRNAs. It has around 3 short paragraphs. This information will help us start, and we will expand upon it.
The talk page requested a clear, general definition at the beginning for someone who knows nothing about 3’ utr’s
history: when was it discovered? What did previous scientists think of its function?
physical: how the mechanism works (looping), how long the 3’ UTR is in different organisms, any patterns within it?
most common UTRs
types of regulation of 3’utr in different organisms
example: progenitors, 3’ UTRs inhibit the production of meiotic and oocyte proteins by post-transcriptional mechanisms involving two classes of RNA-binding proteins
microRNA regulation and polyA tail signal, relating to 3’ UTR and translational regulation– this is already mentioned in the wiki page
example study: human single nucleotide polymorphisms (SNPs) on both seed target region and the rest of 3′UTRs of miRNA target genes were under significantly stronger negative selection, when compared to non-miRNA target genes.
biology techniques used to study it in the past
current research
Dividing up the work:
Bryce: types of regulation, biology techniques
Michael: history, physical characteristics, most common UTRs, general definition