The presence of the cyclic cystine knot (CCK) motif was discovered when cyclotides were isolated from various plant families. The CCK motif has a cyclic backbone, triple stranded beta sheet, and cystine knot conformation. [1]
The GFCK is comprised of four superfamilies. These include nerve growth factor, transforming growth factor beta, platelet-derived growth factor, and glycoprotein hormones, including human chorionic gonadotropin. These are structurally related due to the presence of the cystine knot motif but differ in sequence. [2]
The vascular endothelial growth factor subfamily, categorized as part of the platelet-derived growth factor superfamily, includes proteins that are angiogenic factors. [3]
There are currently novel proteins being added to the cystine knot motif family, which are called the C-terminal cystine knot (CTCK) proteins. They share approximately 90 amino acid residues in their cysteine-rich C terminal regions. [3]
 | This user is a student editor in Hunter_College,_CUNY/Biochemistry_Lab_378_(Spring_2019). |
- ^ "ScienceDirect". www.sciencedirect.com. Retrieved 2019-04-24.
- ^ Sun, P D; Davies, D R (1995). "The Cystine-Knot Growth-Factor Superfamily". Annual Review of Biophysics and Biomolecular Structure. 24 (1): 269–292. doi: 10.1146/annurev.bb.24.060195.001413. PMID 7663117.
- ^
a
b Iyer, Shalini; Acharya, K Ravi (2011-11).
"Tying the knot: The cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines". The Febs Journal. 278 (22): 4304–4322.
doi:
10.1111/j.1742-4658.2011.08350.x.
ISSN
1742-464X.
PMC
PMCPMC3328748.
PMID
21917115.
{{ cite journal}}: Check|pmc=value ( help); Check date values in:|date=( help)
The presence of the cyclic cystine knot (CCK) motif was discovered when cyclotides were isolated from various plant families. The CCK motif has a cyclic backbone, triple stranded beta sheet, and cystine knot conformation. [1]
The GFCK is comprised of four superfamilies. These include nerve growth factor, transforming growth factor beta, platelet-derived growth factor, and glycoprotein hormones, including human chorionic gonadotropin. These are structurally related due to the presence of the cystine knot motif but differ in sequence. [2]
The vascular endothelial growth factor subfamily, categorized as part of the platelet-derived growth factor superfamily, includes proteins that are angiogenic factors. [3]
There are currently novel proteins being added to the cystine knot motif family, which are called the C-terminal cystine knot (CTCK) proteins. They share approximately 90 amino acid residues in their cysteine-rich C terminal regions. [3]
|
| This user is a student editor in Hunter_College,_CUNY/Biochemistry_Lab_378_(Spring_2019). |
- ^ "ScienceDirect". www.sciencedirect.com. Retrieved 2019-04-24.
- ^ Sun, P D; Davies, D R (1995). "The Cystine-Knot Growth-Factor Superfamily". Annual Review of Biophysics and Biomolecular Structure. 24 (1): 269–292. doi: 10.1146/annurev.bb.24.060195.001413. PMID 7663117.
- ^
a
b Iyer, Shalini; Acharya, K Ravi (2011-11).
"Tying the knot: The cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines". The Febs Journal. 278 (22): 4304–4322.
doi:
10.1111/j.1742-4658.2011.08350.x.
ISSN
1742-464X.
PMC
PMCPMC3328748.
PMID
21917115.
{{ cite journal}}: Check|pmc=value ( help); Check date values in:|date=( help)