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 | |
| Clinical data | |
|---|---|
| Trade names | Trevintix |
| Other names | Prothionamide |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C9H12N2S |
| Molar mass | 180.27 g·mol−1 |
| 3D model ( JSmol) | |
| |
| |
 
(what is this?)
(verify) | |
Protionamide, also spelling prothionamide, is an antibiotic used to treat tuberculosis and leprosy. [1] Specifically it is used in multi-drug resistant tuberculosis when other treatment, such as clofazimine, are not suitable. [1] [2] It is used together with other antituberculosis medication. [1] It is taken by mouth for up to two years. [1]
Common side effects include headache, metallic taste, dry mouth, and nausea. [1] Other side effects may include liver problems. [1] Alcohol should be avoided when it is used. [1] Safety in pregnancy and breastfeeding is unclear. [1] It is chemically similar to ethionamide. [2]
Protionamide was discovered in 1956. [3] It is not available in the United Kingdom or United States. [4] [2] It is on the World Health Organization's List of Essential Medicines as an alternative to ethionamide. [5] It was relatively expensive in 2009. [2]
References
- ^ a b c d e f g h i j "Protionamide 250 mg Tablets" (PDF). WHO. Archived (PDF) from the original on 16 September 2023. Retrieved 13 September 2023.
- ^ a b c d Bennett, John E.; Dolin, Raphael; Blaser, Martin J.; Mandell, Gerald L. (19 October 2009). Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book. Elsevier Health Sciences. p. 546. ISBN 978-1-4377-2060-0. Archived from the original on 16 September 2023. Retrieved 13 September 2023.
- ^ Dougherty, Thomas J.; Pucci, Michael J. (21 December 2011). Antibiotic Discovery and Development. Springer Science & Business Media. p. 720. ISBN 978-1-4614-1399-8. Archived from the original on 16 September 2023. Retrieved 13 September 2023.
- ^ "Prothionamide". TB DRUG MONOGRAPHS. Archived from the original on 30 November 2021. Retrieved 13 September 2023.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl: 10665/371090. WHO/MHP/HPS/EML/2023.02.
|
| |
|
| |
| Clinical data | |
|---|---|
| Trade names | Trevintix |
| Other names | Prothionamide |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C9H12N2S |
| Molar mass | 180.27 g·mol−1 |
| 3D model ( JSmol) | |
| |
| |
|
(what is this?)
(verify) | |
Protionamide, also spelling prothionamide, is an antibiotic used to treat tuberculosis and leprosy. [1] Specifically it is used in multi-drug resistant tuberculosis when other treatment, such as clofazimine, are not suitable. [1] [2] It is used together with other antituberculosis medication. [1] It is taken by mouth for up to two years. [1]
Common side effects include headache, metallic taste, dry mouth, and nausea. [1] Other side effects may include liver problems. [1] Alcohol should be avoided when it is used. [1] Safety in pregnancy and breastfeeding is unclear. [1] It is chemically similar to ethionamide. [2]
Protionamide was discovered in 1956. [3] It is not available in the United Kingdom or United States. [4] [2] It is on the World Health Organization's List of Essential Medicines as an alternative to ethionamide. [5] It was relatively expensive in 2009. [2]
References
- ^ a b c d e f g h i j "Protionamide 250 mg Tablets" (PDF). WHO. Archived (PDF) from the original on 16 September 2023. Retrieved 13 September 2023.
- ^ a b c d Bennett, John E.; Dolin, Raphael; Blaser, Martin J.; Mandell, Gerald L. (19 October 2009). Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book. Elsevier Health Sciences. p. 546. ISBN 978-1-4377-2060-0. Archived from the original on 16 September 2023. Retrieved 13 September 2023.
- ^ Dougherty, Thomas J.; Pucci, Michael J. (21 December 2011). Antibiotic Discovery and Development. Springer Science & Business Media. p. 720. ISBN 978-1-4614-1399-8. Archived from the original on 16 September 2023. Retrieved 13 September 2023.
- ^ "Prothionamide". TB DRUG MONOGRAPHS. Archived from the original on 30 November 2021. Retrieved 13 September 2023.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl: 10665/371090. WHO/MHP/HPS/EML/2023.02.