Hodgkin lymphoma
Other names	Hodgkin's lymphoma, Hodgkin's disease [1]
Micrograph showing Hodgkin lymphoma ( Field stain)
Specialty	Hematology and oncology
Symptoms	Fever, night sweats, weight loss, non-painful enlarged lymph nodes [2]
Risk factors	Epstein–Barr virus, family history, HIV/AIDS [2] [3]
Diagnostic method	Lymph node biopsy [2]
Treatment	Chemotherapy, radiation therapy, stem cell transplant [4]
Prognosis	Five-year survival rate 86% (USA) [5]
Frequency	574,000 (affected during 2015) [6]
Deaths	23,900 (2015) [7]

Hodgkin lymphoma (HL) is a type of lymphoma in which cancer originates from a specific type of white blood cells called lymphocytes. ^[8] Symptoms may include fever, night sweats, and weight loss. ^[2] Often there will be non-painful enlarged lymph nodes in the neck, under the arm, or in the groin. ^[2] Those affected may feel tired or be itchy. ^[2]

There are two major types of Hodgkin lymphoma: classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma. ^[5] About half of cases of Hodgkin lymphoma are due to Epstein–Barr virus (EBV) and these are generally the classic form. ^{[3] [9]} Other risk factors include a family history of the condition and having HIV/AIDS. ^{[2] [3]} Diagnosis is by finding Hodgkin cells such as multinucleated Reed–Sternberg cells (RS cells) in lymph nodes. ^[2] The virus-positive cases are classified as a form of the Epstein-Barr virus-associated lymphoproliferative diseases. ^[10]

Hodgkin lymphoma may be treated with chemotherapy, radiation therapy, and stem cell transplant. ^[4] The choice of treatment often depends on how advanced the cancer has become and whether or not it has favorable features. ^[4] In early disease, a cure is often possible. ^[11] The percentage of people who survive five years in the United States is 86%. ^[5] For those under the age of 20, rates of survival are 97%. ^[12] Radiation and some chemotherapy drugs, however, increase the risk of other cancers, heart disease, or lung disease over the subsequent decades. ^[11]

In 2015, about 574,000 people globally had Hodgkin lymphoma, and 23,900 (4.2%) died. ^{[6] [7]} In the United States, 0.2% of people are affected at some point in their life. ^[5] The most common age of diagnosis is between 20 and 40 years old. ^[5] It was named after the English physician Thomas Hodgkin, who first described the condition in 1832. ^{[11] [13]}