Clinical data | |
---|---|
Trade names | Vantas, Supprelin LA, others |
Other names | Histrelin acetate |
AHFS/ Drugs.com | Monograph |
MedlinePlus | a601146 |
Routes of administration | Subcutaneous implant |
Drug class | GnRH agonist; Antigonadotropin |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | 92% |
Protein binding | 70% |
Metabolism | Liver |
Elimination half-life | 4.0 hours |
Identifiers | |
| |
Chemical and physical data | |
Formula | C66H86N18O12 |
Molar mass | 1323.528 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(what is this?) (verify) |
Histrelin, sold under the brand names Vantas among others, is a medication used to treat advanced prostate cancer. [1] It may also be used for precocious puberty and in transgender children. [2] [3] It is given by injection under the skin. [1]
Common side effects include pain at the site of injection, hot flashes, breast enlargement, sexual dysfunction, tiredness, kidney problems, constipation, weight loss, and trouble sleeping. [1] Other side effects may include osteoporosis, high blood sugar, liver problems, anaphylaxis, and pituitary apoplexy. [1] Use in pregnancy may harm the baby. [1] It acts similar to gonadotropin-releasing hormone (GnRH), resulting in increased luteinizing hormone (LH) and follicle stimulating hormone (FSH), and therefore decreased testosterone and estrogen. [1] [3]
Histrelin was approved for medical use in the United States in 1991. [1] It is available as a generic medication. [3] In the United States an implant costs about 5,100 USD per year as of 2021. [4] Since 2014 it is no longer commercially available in the United Kingdom. [5]
Clinical data | |
---|---|
Trade names | Vantas, Supprelin LA, others |
Other names | Histrelin acetate |
AHFS/ Drugs.com | Monograph |
MedlinePlus | a601146 |
Routes of administration | Subcutaneous implant |
Drug class | GnRH agonist; Antigonadotropin |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | 92% |
Protein binding | 70% |
Metabolism | Liver |
Elimination half-life | 4.0 hours |
Identifiers | |
| |
Chemical and physical data | |
Formula | C66H86N18O12 |
Molar mass | 1323.528 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(what is this?) (verify) |
Histrelin, sold under the brand names Vantas among others, is a medication used to treat advanced prostate cancer. [1] It may also be used for precocious puberty and in transgender children. [2] [3] It is given by injection under the skin. [1]
Common side effects include pain at the site of injection, hot flashes, breast enlargement, sexual dysfunction, tiredness, kidney problems, constipation, weight loss, and trouble sleeping. [1] Other side effects may include osteoporosis, high blood sugar, liver problems, anaphylaxis, and pituitary apoplexy. [1] Use in pregnancy may harm the baby. [1] It acts similar to gonadotropin-releasing hormone (GnRH), resulting in increased luteinizing hormone (LH) and follicle stimulating hormone (FSH), and therefore decreased testosterone and estrogen. [1] [3]
Histrelin was approved for medical use in the United States in 1991. [1] It is available as a generic medication. [3] In the United States an implant costs about 5,100 USD per year as of 2021. [4] Since 2014 it is no longer commercially available in the United Kingdom. [5]