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Clinical data | |
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Trade names | Orgalutran, Antagon, Fyremadel, others |
AHFS/ Drugs.com | Monograph |
License data | |
Pregnancy category |
|
Routes of administration | Subcutaneous injection |
Drug class | GnRH antagonist |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 91.1% |
Protein binding | 81.9% |
Elimination half-life | 16.2 hours |
Excretion |
Feces: 75% Urine: 22% |
Identifiers | |
| |
Chemical and physical data | |
Formula | C80H113ClN18O13 |
Molar mass | 1570.35 g·mol−1 |
| |
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Ganirelix, sold under the brand names Orgalutran among others, is a medication used in assisted reproduction to prevent early ovulation. [1] This can increase the number of suitable eggs available for in-vitro fertilisation. [1] It is given by injection under the skin. [3]
Common side effects include abdominal pain, headache, vaginal bleeding, nausea, and ovarian hyperstimulation syndrome. [2] It should not be used in those with latex allergies. [4] It should not be used once pregnancy has occurred. [2] It is a gonadotropin-releasing hormone (GnRH) antagonist. [3] It works by blocking receptors for GnRH, which decreases LH and therefore stops ovulation until this is desired. [1]
Ganirelix was approved for medical use in the United States in 1999 and Europe in 2000. [2] [1] In the United States 5 doses of 0.25 mg costs about 380 USD as of 2021. [5]
![]() | |
Clinical data | |
---|---|
Trade names | Orgalutran, Antagon, Fyremadel, others |
AHFS/ Drugs.com | Monograph |
License data | |
Pregnancy category |
|
Routes of administration | Subcutaneous injection |
Drug class | GnRH antagonist |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 91.1% |
Protein binding | 81.9% |
Elimination half-life | 16.2 hours |
Excretion |
Feces: 75% Urine: 22% |
Identifiers | |
| |
Chemical and physical data | |
Formula | C80H113ClN18O13 |
Molar mass | 1570.35 g·mol−1 |
| |
![]() ![]() |
Ganirelix, sold under the brand names Orgalutran among others, is a medication used in assisted reproduction to prevent early ovulation. [1] This can increase the number of suitable eggs available for in-vitro fertilisation. [1] It is given by injection under the skin. [3]
Common side effects include abdominal pain, headache, vaginal bleeding, nausea, and ovarian hyperstimulation syndrome. [2] It should not be used in those with latex allergies. [4] It should not be used once pregnancy has occurred. [2] It is a gonadotropin-releasing hormone (GnRH) antagonist. [3] It works by blocking receptors for GnRH, which decreases LH and therefore stops ovulation until this is desired. [1]
Ganirelix was approved for medical use in the United States in 1999 and Europe in 2000. [2] [1] In the United States 5 doses of 0.25 mg costs about 380 USD as of 2021. [5]