 | |
 | |
| Clinical data | |
|---|---|
| Pronunciation | /fjʊˈroʊsəˌmaɪd/ |
| Other names | Frusemide |
| AHFS/ Drugs.com | Monograph |
| License data |
|
|
Pregnancy category |
|
|
Routes of administration | By mouth, IV, IM |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | 43–69% |
| Metabolism | Liver and kidney glucuronidation |
| Onset of action | 30 to 60 min (PO), 5 min (IV) [1] |
| Elimination half-life | up to 100 minutes |
| Excretion | renal 66%, biliary 33% |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C12H11ClN2O5S |
| Molar mass | 330.74 g·mol−1 |
| 3D model ( JSmol) | |
| |
| |
| (verify) | |
Furosemide, sold under the brand name Lasix among others, is a medication used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. [1] It may also be used for the treatment of high blood pressure. [1] It can be taken by injection into a vein or by mouth. [1] When taken by mouth, it typically begins working within an hour, while intravenously, it typically begins working within five minutes. [1]
Common side effects include feeling lightheaded with standing, ringing in the ears, and sensitivity to light. [1] Potentially serious side effects include electrolyte abnormalities, low blood pressure, and hearing loss. [1] Blood tests are recommended regularly for those on treatment. [1] Furosemide is a type of loop diuretic that works by decreasing the reabsorption of sodium by the kidneys. [1]
Furosemide was patented in 1959 and approved for medical use in 1964. [3] It is on the World Health Organization's List of Essential Medicines. [4] The wholesale price in the developing world is between US$0.004 and US$0.02 per day. [5] In the United States, it is available as a generic medication and costs about US$0.15 per day. [1] In 2017, it was the 17th most commonly prescribed medication in the United States, with more than 30 million prescriptions. [6] [7] It is on the World Anti-Doping Agency's banned drug list due to concerns that it may mask other drugs. [8] It has also been used in race horses for the treatment and prevention of exercise-induced pulmonary hemorrhage. [9] [10]
References
- ^ a b c d e f g h i j k "Furosemide". The American Society of Health-System Pharmacists. Archived from the original on 2015-11-19. Retrieved October 23, 2015.
-
^ Cite error: The named reference
WHO2020DDDwas invoked but never defined (see the help page). - ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 458. ISBN 9783527607495. Archived from the original on 2019-03-01. Retrieved 2019-03-01.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl: 10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ "Furosemide". International Drug Price Indicator Guide. Archived from the original on 10 May 2017. Retrieved 24 October 2015.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
- ^ "Furosemide - Drug Usage Statistics". ClinCalc. 1 December 1981. Archived from the original on 11 April 2020. Retrieved 11 April 2020.
- ^ "THE 2014 PROHIBITED LIST INTERNATIONAL STANDARD" (PDF). 2014. p. 5. Archived (PDF) from the original on 15 January 2016. Retrieved 24 October 2015.
- ^ Sullivan, S; Hinchcliff, K (April 2015). "Update on exercise-induced pulmonary hemorrhage". The Veterinary Clinics of North America. Equine Practice. 31 (1): 187–98. doi: 10.1016/j.cveq.2014.11.011. PMID 25770069.
- ^ Hinchcliff, KW; Couetil, LL; Knight, PK; Morley, PS; Robinson, NE; Sweeney, CR; van Erck, E (2015). "Exercise induced pulmonary hemorrhage in horses: American College of Veterinary Internal Medicine consensus statement". Journal of Veterinary Internal Medicine. 29 (3): 743–58. doi: 10.1111/jvim.12593. PMC 4895427. PMID 25996660.
|
| |
|
| |
| Clinical data | |
|---|---|
| Pronunciation | /fjʊˈroʊsəˌmaɪd/ |
| Other names | Frusemide |
| AHFS/ Drugs.com | Monograph |
| License data |
|
|
Pregnancy category |
|
|
Routes of administration | By mouth, IV, IM |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | 43–69% |
| Metabolism | Liver and kidney glucuronidation |
| Onset of action | 30 to 60 min (PO), 5 min (IV) [1] |
| Elimination half-life | up to 100 minutes |
| Excretion | renal 66%, biliary 33% |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C12H11ClN2O5S |
| Molar mass | 330.74 g·mol−1 |
| 3D model ( JSmol) | |
| |
| |
| (verify) | |
Furosemide, sold under the brand name Lasix among others, is a medication used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. [1] It may also be used for the treatment of high blood pressure. [1] It can be taken by injection into a vein or by mouth. [1] When taken by mouth, it typically begins working within an hour, while intravenously, it typically begins working within five minutes. [1]
Common side effects include feeling lightheaded with standing, ringing in the ears, and sensitivity to light. [1] Potentially serious side effects include electrolyte abnormalities, low blood pressure, and hearing loss. [1] Blood tests are recommended regularly for those on treatment. [1] Furosemide is a type of loop diuretic that works by decreasing the reabsorption of sodium by the kidneys. [1]
Furosemide was patented in 1959 and approved for medical use in 1964. [3] It is on the World Health Organization's List of Essential Medicines. [4] The wholesale price in the developing world is between US$0.004 and US$0.02 per day. [5] In the United States, it is available as a generic medication and costs about US$0.15 per day. [1] In 2017, it was the 17th most commonly prescribed medication in the United States, with more than 30 million prescriptions. [6] [7] It is on the World Anti-Doping Agency's banned drug list due to concerns that it may mask other drugs. [8] It has also been used in race horses for the treatment and prevention of exercise-induced pulmonary hemorrhage. [9] [10]
References
- ^ a b c d e f g h i j k "Furosemide". The American Society of Health-System Pharmacists. Archived from the original on 2015-11-19. Retrieved October 23, 2015.
-
^ Cite error: The named reference
WHO2020DDDwas invoked but never defined (see the help page). - ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 458. ISBN 9783527607495. Archived from the original on 2019-03-01. Retrieved 2019-03-01.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl: 10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ "Furosemide". International Drug Price Indicator Guide. Archived from the original on 10 May 2017. Retrieved 24 October 2015.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
- ^ "Furosemide - Drug Usage Statistics". ClinCalc. 1 December 1981. Archived from the original on 11 April 2020. Retrieved 11 April 2020.
- ^ "THE 2014 PROHIBITED LIST INTERNATIONAL STANDARD" (PDF). 2014. p. 5. Archived (PDF) from the original on 15 January 2016. Retrieved 24 October 2015.
- ^ Sullivan, S; Hinchcliff, K (April 2015). "Update on exercise-induced pulmonary hemorrhage". The Veterinary Clinics of North America. Equine Practice. 31 (1): 187–98. doi: 10.1016/j.cveq.2014.11.011. PMID 25770069.
- ^ Hinchcliff, KW; Couetil, LL; Knight, PK; Morley, PS; Robinson, NE; Sweeney, CR; van Erck, E (2015). "Exercise induced pulmonary hemorrhage in horses: American College of Veterinary Internal Medicine consensus statement". Journal of Veterinary Internal Medicine. 29 (3): 743–58. doi: 10.1111/jvim.12593. PMC 4895427. PMID 25996660.