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Clinical data | |
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Trade names | Foscavir |
Other names | Foscarnet sodium, phosphonomethanoic acid, dihydroxyphosphinecarboxylic acid oxide |
AHFS/ Drugs.com | Monograph |
MedlinePlus | a601144 |
License data | |
Pregnancy category |
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Routes of administration | Intravenous |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | NA |
Protein binding | 14–17% |
Elimination half-life | 3.3–6.8 hours |
Identifiers | |
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Chemical and physical data | |
Formula | CH3O5P |
Molar mass | 126.004 g·mol−1 |
3D model ( JSmol) | |
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Foscarnet, sold under the brand name Foscavir, is an antiviral used to treat cytomegalovirus (CMV), herpes simplex virus (HSV), and varicella zoster virus (VZV). [2] Primarily this is those who are immunocompromised such as due to HIV/AIDS. [2] It is given by injection into a vein. [3]
Common side effects include fever, nausea, low red blood cells, kidney problems, seizures, and headache. [2] Other side effects may include electrolyte abnormalities, prolonged QT, and anaphylaxis. [2] Safety in pregnancy is unclear. [2] It acts similar to pyrophosphate as a viral DNA polymerase inhibitor. [2]
Foscarnet was approved for medical use in the United States in 1991. [4] [2] In the United Kingdom 6 grams costs the NHS about £120 as of 2021. [3] This amount in the United States cost about 4,800 USD. [5]
![]() | |
![]() | |
Clinical data | |
---|---|
Trade names | Foscavir |
Other names | Foscarnet sodium, phosphonomethanoic acid, dihydroxyphosphinecarboxylic acid oxide |
AHFS/ Drugs.com | Monograph |
MedlinePlus | a601144 |
License data | |
Pregnancy category |
|
Routes of administration | Intravenous |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | NA |
Protein binding | 14–17% |
Elimination half-life | 3.3–6.8 hours |
Identifiers | |
| |
Chemical and physical data | |
Formula | CH3O5P |
Molar mass | 126.004 g·mol−1 |
3D model ( JSmol) | |
| |
| |
![]() ![]() |
Foscarnet, sold under the brand name Foscavir, is an antiviral used to treat cytomegalovirus (CMV), herpes simplex virus (HSV), and varicella zoster virus (VZV). [2] Primarily this is those who are immunocompromised such as due to HIV/AIDS. [2] It is given by injection into a vein. [3]
Common side effects include fever, nausea, low red blood cells, kidney problems, seizures, and headache. [2] Other side effects may include electrolyte abnormalities, prolonged QT, and anaphylaxis. [2] Safety in pregnancy is unclear. [2] It acts similar to pyrophosphate as a viral DNA polymerase inhibitor. [2]
Foscarnet was approved for medical use in the United States in 1991. [4] [2] In the United Kingdom 6 grams costs the NHS about £120 as of 2021. [3] This amount in the United States cost about 4,800 USD. [5]