| |||
| Clinical data | |||
|---|---|---|---|
| Other names | Ergonovine, d-lysergic acid beta-propanolamide | ||
| AHFS/ Drugs.com | Monograph | ||
|
Pregnancy category |
| ||
|
Routes of administration | By mouth | ||
| Legal status | |||
| Legal status |
| ||
| Pharmacokinetic data | |||
| Metabolism | Liver (partly CYP3A4) | ||
| Elimination half-life | 2-phase (10 min; 2 hrs) | ||
| Excretion | Biliary | ||
| Identifiers | |||
| |||
| Chemical and physical data | |||
| Formula | C19H23N3O2 | ||
| Molar mass | 325.412 g·mol−1 | ||
| 3D model ( JSmol) | |||
| |||
| |||
| (verify) | |||
Ergometrine, also known as ergonovine, is a medication used to cause contractions of the uterus to treat heavy vaginal bleeding after childbirth. [2] It can be used either by mouth, by injection into a muscle, or injection into a vein. [2] It begins working within 15 minutes when taken by mouth and is faster in onset when used by injection. [2] Effects last between 45 and 180 minutes. [2]
Common side effect include high blood pressure, vomiting, seizures, headache, and low blood pressure. [2] Other serious side effects include ergotism. [2] It was originally made from the rye ergot fungus but can also be made from lysergic acid. [3] [4] Ergometrine is regulated because it can be used to make lysergic acid diethylamide (LSD). [5]
Ergometrine was discovered in 1932. [3] It is on the World Health Organization's List of Essential Medicines. [6] The wholesale cost in the developing world is between US$0.12 and US$0.41 for an injectable dose and US$0.01 for a pill as of 2014. [7] [8] In the United States it is about US$1.75 per dose. [2]
-
^ Cite error: The named reference
whowas invoked but never defined (see the help page). - ^ a b c d e f g "Ergonovine Maleate". The American Society of Health-System Pharmacists. Archived from the original on 2015-12-25. Retrieved 1 December 2015.
- ^ a b Ravina, Enrique (2011). The evolution of drug discovery : from traditional medicines to modern drugs (1. Aufl. ed.). Weinheim: Wiley-VCH. p. 245. ISBN 9783527326693. Archived from the original on 2015-12-26.
- ^ Sneader, Walter (2005). Drug discovery : a history (Rev. and updated ed.). Chichester: Wiley. p. 349. ISBN 9780471899792. Archived from the original on 2015-12-26.
- ^ King, L.A. (2009). Forensic chemistry of substance misuse : a guide to drug control. Cambridge, UK: Royal Society of Chemistry. p. 190. ISBN 9780854041787. Archived from the original on 2015-12-26.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl: 10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ "Ergometrine Maleate". International Drug Price Indicator Guide. Archived from the original on 22 January 2018. Retrieved 25 December 2015.
- ^ "Ergometrine Maleate". International Drug Price Indicator Guide. Archived from the original on 22 January 2018. Retrieved 25 December 2015.
| |||
| Clinical data | |||
|---|---|---|---|
| Other names | Ergonovine, d-lysergic acid beta-propanolamide | ||
| AHFS/ Drugs.com | Monograph | ||
|
Pregnancy category |
| ||
|
Routes of administration | By mouth | ||
| Legal status | |||
| Legal status |
| ||
| Pharmacokinetic data | |||
| Metabolism | Liver (partly CYP3A4) | ||
| Elimination half-life | 2-phase (10 min; 2 hrs) | ||
| Excretion | Biliary | ||
| Identifiers | |||
| |||
| Chemical and physical data | |||
| Formula | C19H23N3O2 | ||
| Molar mass | 325.412 g·mol−1 | ||
| 3D model ( JSmol) | |||
| |||
| |||
| (verify) | |||
Ergometrine, also known as ergonovine, is a medication used to cause contractions of the uterus to treat heavy vaginal bleeding after childbirth. [2] It can be used either by mouth, by injection into a muscle, or injection into a vein. [2] It begins working within 15 minutes when taken by mouth and is faster in onset when used by injection. [2] Effects last between 45 and 180 minutes. [2]
Common side effect include high blood pressure, vomiting, seizures, headache, and low blood pressure. [2] Other serious side effects include ergotism. [2] It was originally made from the rye ergot fungus but can also be made from lysergic acid. [3] [4] Ergometrine is regulated because it can be used to make lysergic acid diethylamide (LSD). [5]
Ergometrine was discovered in 1932. [3] It is on the World Health Organization's List of Essential Medicines. [6] The wholesale cost in the developing world is between US$0.12 and US$0.41 for an injectable dose and US$0.01 for a pill as of 2014. [7] [8] In the United States it is about US$1.75 per dose. [2]
-
^ Cite error: The named reference
whowas invoked but never defined (see the help page). - ^ a b c d e f g "Ergonovine Maleate". The American Society of Health-System Pharmacists. Archived from the original on 2015-12-25. Retrieved 1 December 2015.
- ^ a b Ravina, Enrique (2011). The evolution of drug discovery : from traditional medicines to modern drugs (1. Aufl. ed.). Weinheim: Wiley-VCH. p. 245. ISBN 9783527326693. Archived from the original on 2015-12-26.
- ^ Sneader, Walter (2005). Drug discovery : a history (Rev. and updated ed.). Chichester: Wiley. p. 349. ISBN 9780471899792. Archived from the original on 2015-12-26.
- ^ King, L.A. (2009). Forensic chemistry of substance misuse : a guide to drug control. Cambridge, UK: Royal Society of Chemistry. p. 190. ISBN 9780854041787. Archived from the original on 2015-12-26.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl: 10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ "Ergometrine Maleate". International Drug Price Indicator Guide. Archived from the original on 22 January 2018. Retrieved 25 December 2015.
- ^ "Ergometrine Maleate". International Drug Price Indicator Guide. Archived from the original on 22 January 2018. Retrieved 25 December 2015.