Clinical data | |
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Pronunciation | /daɪˌhaɪdroʊ.ɜːrˈɡɒtəmiːn/ dy-HY-droh-ur-GOT-ə-meen |
Trade names | D.H.E. 45, Migranal, others |
Other names | DHE; (5'α)-9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-ergotaman-3',6',18-trione |
AHFS/ Drugs.com | Monograph |
MedlinePlus | a603022 |
License data |
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Routes of administration | Nasal spray, SC, IM, IV [1] |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | 32% (nasal spray) |
Onset of action | Within 5 min (IV), About 30 min (IN) [2] |
Elimination half-life | 9 hours |
Excretion | Bile |
Identifiers | |
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Chemical and physical data | |
Formula | C33H37N5O5 |
Molar mass | 583.689 g·mol−1 |
3D model ( JSmol) | |
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(verify) |
Dihydroergotamine (DHE), sold under the brand name Migranal among others, is a medication used to treat migraines, cluster headaches, and medication overuse headaches. [2] [3] It has a particular benefit in hard to treat migraines. [4] It may be used as a nasal spray or by injection. [1] Onset is within 5 to 30 minutes. [2]
Common side effects include high blood pressure, flushing, sweating, and nausea. [2] Other side effects may include myocardial ischemia, stroke, arrhythmia, and ergotism. [2] Use is not recommended during pregnancy, in those with liver or kidney problems, or those with vascular disease. [1] It is a derivative of ergotamine. [4] It activates serotonin receptors as well as dopamine and adrenergic receptors. [4]
Dihydroergotamine was first made in 1943 and has been in medical use since. [1] [4] It is available as a generic medication. [5] In the United States it costs about 45 USD per dose by injection and 370 USD per dose in the nose as of 2021. [5] [6] As of the 2010s it is less commonly used than triptans. [7]
{{
cite journal}}
: CS1 maint: unflagged free DOI (
link)
Clinical data | |
---|---|
Pronunciation | /daɪˌhaɪdroʊ.ɜːrˈɡɒtəmiːn/ dy-HY-droh-ur-GOT-ə-meen |
Trade names | D.H.E. 45, Migranal, others |
Other names | DHE; (5'α)-9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-ergotaman-3',6',18-trione |
AHFS/ Drugs.com | Monograph |
MedlinePlus | a603022 |
License data |
|
Routes of administration | Nasal spray, SC, IM, IV [1] |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | 32% (nasal spray) |
Onset of action | Within 5 min (IV), About 30 min (IN) [2] |
Elimination half-life | 9 hours |
Excretion | Bile |
Identifiers | |
| |
Chemical and physical data | |
Formula | C33H37N5O5 |
Molar mass | 583.689 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(verify) |
Dihydroergotamine (DHE), sold under the brand name Migranal among others, is a medication used to treat migraines, cluster headaches, and medication overuse headaches. [2] [3] It has a particular benefit in hard to treat migraines. [4] It may be used as a nasal spray or by injection. [1] Onset is within 5 to 30 minutes. [2]
Common side effects include high blood pressure, flushing, sweating, and nausea. [2] Other side effects may include myocardial ischemia, stroke, arrhythmia, and ergotism. [2] Use is not recommended during pregnancy, in those with liver or kidney problems, or those with vascular disease. [1] It is a derivative of ergotamine. [4] It activates serotonin receptors as well as dopamine and adrenergic receptors. [4]
Dihydroergotamine was first made in 1943 and has been in medical use since. [1] [4] It is available as a generic medication. [5] In the United States it costs about 45 USD per dose by injection and 370 USD per dose in the nose as of 2021. [5] [6] As of the 2010s it is less commonly used than triptans. [7]
{{
cite journal}}
: CS1 maint: unflagged free DOI (
link)