 | |
 | |
| Clinical data | |
|---|---|
| Pronunciation |
US:
/ˌkælsɪˈtraɪɒl/;
[1]
[2]
[3]
[4]
[5] UK: /kælˈsɪtriɒl/ |
| Trade names | Rocaltrol, Calcijex, Decostriol, others |
| Other names | 1,25-dihydroxycholecalciferol, 1alpha,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D3, 1α,25-(OH)2D3, 1,25(OH)2D [6] |
| AHFS/ Drugs.com | Monograph |
| MedlinePlus | a682335 |
| License data |
|
|
Pregnancy category |
|
|
Routes of administration | By mouth, IV [7] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Protein binding | 99.9% |
| Metabolism | Kidney |
| Elimination half-life | 5–8 hours (adults), 27 hours (children) |
| Excretion | Faeces (50%), urine (16%) |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C27H44O3 |
| Molar mass | 416.646 g·mol−1 |
| 3D model ( JSmol) | |
| |
| |
| (verify) | |
Calcitriol is the active form of vitamin D, normally made in the kidney. [10] A manufactured form is used to treat kidney disease with low blood calcium, hyperparathyroidism due to kidney disease, low blood calcium due to hypoparathyroidism, osteoporosis, osteomalacia, and familial hypophosphatemia. [7] [8] It is taken by mouth or by injection into a vein. [7]
Excessive amount commonly results in weakness, headache, nausea, constipation, urinary tract infections, and abdominal pain. [7] [8] Serious side effects may include high blood calcium and anaphylaxis. [7] Regular blood tests are recommended after the medication is started and when the dose is changed. [8] Calcitriol increases blood calcium (Ca2+) mainly by increasing the uptake of calcium from the intestines. [7]
Calcitriol was approved for medical use in the United States in 1978. [7] It is on the World Health Organization's List of Essential Medicines as an alternative to calcipotriol. [11] It is available as a generic medication. [8] A month supply in the United Kingdom costs the NHS about 9.70 £ as of 2019. [8] In the United States the wholesale cost of this amount is about US$27. [12] In 2017, it was the 256th most commonly prescribed medication in the United States, with more than one million prescriptions. [13] [14]
References
- ^ Elsevier, Dorland's Illustrated Medical Dictionary, Elsevier, archived from the original on 2014-01-11, retrieved 2015-09-25.
- ^ Wolters Kluwer, Stedman's Medical Dictionary, Wolters Kluwer, archived from the original on 2015-09-25, retrieved 2015-09-25.
- ^ Merriam-Webster, Merriam-Webster's Medical Dictionary, Merriam-Webster, archived from the original on 2020-10-10, retrieved 2015-09-25.
- ^ Houghton Mifflin Harcourt, The American Heritage Dictionary of the English Language, Houghton Mifflin Harcourt, archived from the original on 2015-09-25, retrieved 2015-09-25.
- ^ Merriam-Webster, Merriam-Webster's Unabridged Dictionary, Merriam-Webster, archived from the original on 2020-05-25, retrieved 2015-09-25.
- ^ "IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN): Nomenclature of vitamin D. Recommendations 1981". European Journal of Biochemistry. 124 (2): 223–7. May 1982. doi: 10.1111/j.1432-1033.1982.tb06581.x. PMID 7094913.
- ^ a b c d e f g h i "Calcitriol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 13 December 2019. Retrieved 9 April 2019.
- ^ a b c d e f g British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 1050–1051. ISBN 9780857113382.
-
^ Cite error: The named reference
WHO2020DDDwas invoked but never defined (see the help page). - ^ Encyclopedia of Endocrine Diseases. Academic Press. 2018. p. 344. ISBN 9780128122006. Archived from the original on 2020-08-19. Retrieved 2019-04-13.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl: 10665/371090. WHO/MHP/HPS/EML/2023.02.
- ^ "CY 2016 Outlier Services" (PDF). Archived (PDF) from the original on 31 May 2019. Retrieved 13 April 2019.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
- ^ "Calcitriol - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.
|
| |
|
| |
| Clinical data | |
|---|---|
| Pronunciation |
US:
/ˌkælsɪˈtraɪɒl/;
[1]
[2]
[3]
[4]
[5] UK: /kælˈsɪtriɒl/ |
| Trade names | Rocaltrol, Calcijex, Decostriol, others |
| Other names | 1,25-dihydroxycholecalciferol, 1alpha,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D3, 1α,25-(OH)2D3, 1,25(OH)2D [6] |
| AHFS/ Drugs.com | Monograph |
| MedlinePlus | a682335 |
| License data |
|
|
Pregnancy category |
|
|
Routes of administration | By mouth, IV [7] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Protein binding | 99.9% |
| Metabolism | Kidney |
| Elimination half-life | 5–8 hours (adults), 27 hours (children) |
| Excretion | Faeces (50%), urine (16%) |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C27H44O3 |
| Molar mass | 416.646 g·mol−1 |
| 3D model ( JSmol) | |
| |
| |
| (verify) | |
Calcitriol is the active form of vitamin D, normally made in the kidney. [10] A manufactured form is used to treat kidney disease with low blood calcium, hyperparathyroidism due to kidney disease, low blood calcium due to hypoparathyroidism, osteoporosis, osteomalacia, and familial hypophosphatemia. [7] [8] It is taken by mouth or by injection into a vein. [7]
Excessive amount commonly results in weakness, headache, nausea, constipation, urinary tract infections, and abdominal pain. [7] [8] Serious side effects may include high blood calcium and anaphylaxis. [7] Regular blood tests are recommended after the medication is started and when the dose is changed. [8] Calcitriol increases blood calcium (Ca2+) mainly by increasing the uptake of calcium from the intestines. [7]
Calcitriol was approved for medical use in the United States in 1978. [7] It is on the World Health Organization's List of Essential Medicines as an alternative to calcipotriol. [11] It is available as a generic medication. [8] A month supply in the United Kingdom costs the NHS about 9.70 £ as of 2019. [8] In the United States the wholesale cost of this amount is about US$27. [12] In 2017, it was the 256th most commonly prescribed medication in the United States, with more than one million prescriptions. [13] [14]
References
- ^ Elsevier, Dorland's Illustrated Medical Dictionary, Elsevier, archived from the original on 2014-01-11, retrieved 2015-09-25.
- ^ Wolters Kluwer, Stedman's Medical Dictionary, Wolters Kluwer, archived from the original on 2015-09-25, retrieved 2015-09-25.
- ^ Merriam-Webster, Merriam-Webster's Medical Dictionary, Merriam-Webster, archived from the original on 2020-10-10, retrieved 2015-09-25.
- ^ Houghton Mifflin Harcourt, The American Heritage Dictionary of the English Language, Houghton Mifflin Harcourt, archived from the original on 2015-09-25, retrieved 2015-09-25.
- ^ Merriam-Webster, Merriam-Webster's Unabridged Dictionary, Merriam-Webster, archived from the original on 2020-05-25, retrieved 2015-09-25.
- ^ "IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN): Nomenclature of vitamin D. Recommendations 1981". European Journal of Biochemistry. 124 (2): 223–7. May 1982. doi: 10.1111/j.1432-1033.1982.tb06581.x. PMID 7094913.
- ^ a b c d e f g h i "Calcitriol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 13 December 2019. Retrieved 9 April 2019.
- ^ a b c d e f g British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 1050–1051. ISBN 9780857113382.
-
^ Cite error: The named reference
WHO2020DDDwas invoked but never defined (see the help page). - ^ Encyclopedia of Endocrine Diseases. Academic Press. 2018. p. 344. ISBN 9780128122006. Archived from the original on 2020-08-19. Retrieved 2019-04-13.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl: 10665/371090. WHO/MHP/HPS/EML/2023.02.
- ^ "CY 2016 Outlier Services" (PDF). Archived (PDF) from the original on 31 May 2019. Retrieved 13 April 2019.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
- ^ "Calcitriol - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.