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TEKTIP1, also known as tektin-bundle interacting protein 1 is a protein that in humans is encoded by the TEKTIP1 gene. [1]
Tektin bundle interacting protein 1 (TEKTIP1) is a protein which in humans is encoded by the TEKTIP1 mRNA. [1] The longest mRNA produced is 826 bases long. [2]
Alias of the protein is C19orf71. [3] Locus
The TEKTIP1 gene is located at 19p13.3. [4]
Transcriptional Regulation
Several predicted transcription factors may bind in the promoter region: TFDP1, PLAGL1, ZSCAN4, POU2F3. [5] [6] [7] [8] [9] [10] [11]
Chemical Interactions
Acrylamide [12], cisplatin [13], and silicon dioxide [14] decrease expression, while butanal ( butyraldehyde), and pentanal increase expression [15] of TEKTIP1 mRNA.
Sequence orthology also suggests that valproic acid increases methylation of TEKTIP1 mRNA. [16]
The mRNA of TEKTIP1 is 654 nucleotides long. [1] [3] It contains five exons. [1] The human TEKTIP1 protein is 209 amino acids long and and has a predicted molecular mass of 24.5 kDa. [3] The human protein has a theoretical isoelectric point of 9.1. [17]
Isoforms
There are two splice isoforms of the protein, X1 [18] and X2 [19].
X1 | X2 |
---|---|
Tibetan macaque [20] | Chimpanzee [21] |
Olive baboon [22] | Olive baboon [23] |
Panamanian white-faced capuchin [24] | Common marmoset [25] |
Golden
[26] and Black
[27]
snub-nosed monkeys |
Golden sub-nosed monkey [28] |
Elk [29] | Elk [30] |
Red deer [31] | Red deer [32] |
Greater horseshoe bat [33] | Bats [34] [35] [36] |
Red fox [37] | Polar bear [38] |
Characteristics & structure
TEKTIP1 is highly enriched in tryptophan and tyrosine. [40] Additionally, the protein is semi-enriched in arginine and proline. [41]
TEKTIP1 is tissue specific and is found in higher levels in the kidney, testis and thymus. [4]
In fetal development, it is found in higher levels in the Adrenal glands during weeks 16-20. [4]
TEKTIP1 protein is said to be specific to the testis and is found in early spermatids during spermatogenesis. [42]
Over 240 organisms have orthologs with human gene TEKTIP1. [4] The most distant organism with an orthologous sequence to human TEKTIP1 is the West African lungfish (estimated date of divergence of 408 MYA). [44] [45]
Genus and Species | Common Name | Taxonomic Group | Median Date of Divergence (MYA) | Accession # | Sequence length (aa) | Sequence Identity to Human Protein % | Sequence Similarity to Human Protein % |
---|---|---|---|---|---|---|---|
Homo sapein | Human | Primates/Hominidae | 0 | NP_001129052.1 | 209 | 100 | 100 |
Pan troglodyte | Chimpanzee | Primates | 6.4 | XP_003316050.1 | 209 | 98.1 | 98.6 |
Mus musculus | Mouse | Rodentia | 87 | NP_001014836.2 | 217 | 45.6 | 60.4 |
Bos taurus | Cow | Artiodactyla | 94 | NP_001070550 | 208 | 76.6 | 84.2 |
Panthera tigris | Tiger | Carnivora | 94 | XP_042833719.1 | 210 | 34.1 | 38.9 |
Orcinus orca | Killer whale | Cetacea | 94 | XP_012394771.2 | 216 | 63 | 73.1 |
Phascolarctos cinereus | Koala | Diprodontia | 160 | XP_020824948.1 | 211 | 52.9 | 67.4 |
Haliaeetus leucocephalus | Bald Eagle | Accipitiformes | 319 | XP_010580112.1 | 206 | 41.4 | 52 |
Dromaius novaehollandiae | Emu | Aves | 319 | XP_025961204.1 | 190 | 44.8 | 56.7 |
Gallus gallus domesticus | Chicken | Aves | 319 | XP_015155269.2 | 188 | 38.2 | 48.4 |
Crocodylus porosus | Saltwater Crocodile | Crocodilia | 319 | XP_019406144.1 | 210 | 54.3 | 68.3 |
Caretta caretta | Loggerhead Sea Turtle | Testudines | 319 | XP_048687032.1 | 216 | 47.8 | 57.3 |
Zootoca vivipara | Common lizard | Squamata | 319 | XP_034975173.1 | 200 | 48.8 | 59.5 |
Crotalus tigris | Tiger Rattlesnake | Squamata | 319 | XP_039190693.1 | 199 | 45.8 | 57.5 |
Protobothrops mucrosquamatus | Venomous Pit Viper | Squamata | 319 | XP_015665555.1 | 199 | 45.1 | 56.7 |
Bufo bufo | Common Toad | Salientia | 353 | XP_040276375 | 136 | 24.7 | 34.3 |
Geotrypetes seraphini | Gaboon Caecilian | Caecilians | 353 | XP_033813379.1 | 156 | 36.1 | 45.8 |
Microcaecilia unicolor | Tiny Caecilian | Caecilians | 353 | XP_030074922.1 | 142 | 34.3 | 42.6 |
Protopterus annectens | West African Lungfish | Actinopterygii | 408 | XP_043910031.1 | 142 | 28.6 | 39 |
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![]() | This is not a Wikipedia article: It is an individual user's work-in-progress page, and may be incomplete and/or unreliable. For guidance on developing this draft, see
Wikipedia:So you made a userspace draft. Find sources:
Google (
books ·
news ·
scholar ·
free images ·
WP refs) ·
FENS ·
JSTOR ·
TWL |
TEKTIP1, also known as tektin-bundle interacting protein 1 is a protein that in humans is encoded by the TEKTIP1 gene. [1]
Tektin bundle interacting protein 1 (TEKTIP1) is a protein which in humans is encoded by the TEKTIP1 mRNA. [1] The longest mRNA produced is 826 bases long. [2]
Alias of the protein is C19orf71. [3] Locus
The TEKTIP1 gene is located at 19p13.3. [4]
Transcriptional Regulation
Several predicted transcription factors may bind in the promoter region: TFDP1, PLAGL1, ZSCAN4, POU2F3. [5] [6] [7] [8] [9] [10] [11]
Chemical Interactions
Acrylamide [12], cisplatin [13], and silicon dioxide [14] decrease expression, while butanal ( butyraldehyde), and pentanal increase expression [15] of TEKTIP1 mRNA.
Sequence orthology also suggests that valproic acid increases methylation of TEKTIP1 mRNA. [16]
The mRNA of TEKTIP1 is 654 nucleotides long. [1] [3] It contains five exons. [1] The human TEKTIP1 protein is 209 amino acids long and and has a predicted molecular mass of 24.5 kDa. [3] The human protein has a theoretical isoelectric point of 9.1. [17]
Isoforms
There are two splice isoforms of the protein, X1 [18] and X2 [19].
X1 | X2 |
---|---|
Tibetan macaque [20] | Chimpanzee [21] |
Olive baboon [22] | Olive baboon [23] |
Panamanian white-faced capuchin [24] | Common marmoset [25] |
Golden
[26] and Black
[27]
snub-nosed monkeys |
Golden sub-nosed monkey [28] |
Elk [29] | Elk [30] |
Red deer [31] | Red deer [32] |
Greater horseshoe bat [33] | Bats [34] [35] [36] |
Red fox [37] | Polar bear [38] |
Characteristics & structure
TEKTIP1 is highly enriched in tryptophan and tyrosine. [40] Additionally, the protein is semi-enriched in arginine and proline. [41]
TEKTIP1 is tissue specific and is found in higher levels in the kidney, testis and thymus. [4]
In fetal development, it is found in higher levels in the Adrenal glands during weeks 16-20. [4]
TEKTIP1 protein is said to be specific to the testis and is found in early spermatids during spermatogenesis. [42]
Over 240 organisms have orthologs with human gene TEKTIP1. [4] The most distant organism with an orthologous sequence to human TEKTIP1 is the West African lungfish (estimated date of divergence of 408 MYA). [44] [45]
Genus and Species | Common Name | Taxonomic Group | Median Date of Divergence (MYA) | Accession # | Sequence length (aa) | Sequence Identity to Human Protein % | Sequence Similarity to Human Protein % |
---|---|---|---|---|---|---|---|
Homo sapein | Human | Primates/Hominidae | 0 | NP_001129052.1 | 209 | 100 | 100 |
Pan troglodyte | Chimpanzee | Primates | 6.4 | XP_003316050.1 | 209 | 98.1 | 98.6 |
Mus musculus | Mouse | Rodentia | 87 | NP_001014836.2 | 217 | 45.6 | 60.4 |
Bos taurus | Cow | Artiodactyla | 94 | NP_001070550 | 208 | 76.6 | 84.2 |
Panthera tigris | Tiger | Carnivora | 94 | XP_042833719.1 | 210 | 34.1 | 38.9 |
Orcinus orca | Killer whale | Cetacea | 94 | XP_012394771.2 | 216 | 63 | 73.1 |
Phascolarctos cinereus | Koala | Diprodontia | 160 | XP_020824948.1 | 211 | 52.9 | 67.4 |
Haliaeetus leucocephalus | Bald Eagle | Accipitiformes | 319 | XP_010580112.1 | 206 | 41.4 | 52 |
Dromaius novaehollandiae | Emu | Aves | 319 | XP_025961204.1 | 190 | 44.8 | 56.7 |
Gallus gallus domesticus | Chicken | Aves | 319 | XP_015155269.2 | 188 | 38.2 | 48.4 |
Crocodylus porosus | Saltwater Crocodile | Crocodilia | 319 | XP_019406144.1 | 210 | 54.3 | 68.3 |
Caretta caretta | Loggerhead Sea Turtle | Testudines | 319 | XP_048687032.1 | 216 | 47.8 | 57.3 |
Zootoca vivipara | Common lizard | Squamata | 319 | XP_034975173.1 | 200 | 48.8 | 59.5 |
Crotalus tigris | Tiger Rattlesnake | Squamata | 319 | XP_039190693.1 | 199 | 45.8 | 57.5 |
Protobothrops mucrosquamatus | Venomous Pit Viper | Squamata | 319 | XP_015665555.1 | 199 | 45.1 | 56.7 |
Bufo bufo | Common Toad | Salientia | 353 | XP_040276375 | 136 | 24.7 | 34.3 |
Geotrypetes seraphini | Gaboon Caecilian | Caecilians | 353 | XP_033813379.1 | 156 | 36.1 | 45.8 |
Microcaecilia unicolor | Tiny Caecilian | Caecilians | 353 | XP_030074922.1 | 142 | 34.3 | 42.6 |
Protopterus annectens | West African Lungfish | Actinopterygii | 408 | XP_043910031.1 | 142 | 28.6 | 39 |
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