- Titus Andronicus - Titus Andronicus, has his hand cut off by Aaron.
- Aquaman - DC Comics, hand lost in various different manners (depending on the series) and replaced with a harpoon head (later an advanced cybernetically-controlled version of the same) and eventually with a hand-shaped field of water.
- Ash - " Evil Dead" trilogy, amputates right hand after it becomes possessed by the evil "Deadite" force, replaces it with a chainsaw mounted to his wrist and later, a mechanical prosthetic metal hand.
- Colonel Steve Austin - The Six Million Dollar Man and the book Cyborg by Martin Caidin, lost right arm in test flight accident, in addition to both legs and left eye. Replaced by cybernetic implants provided by Office of Scientific Intelligence.
- Bink - Xanth, cut off finger in childhood playing with a large knife. Restored later by a healing spring.
- Frodo Baggins - The Lord of the Rings, had a finger bitten off by Gollum.
- Baiken - Guilty Gear, lost her right arm and left eye in a Gear attack on Japan.
- Bald - Fullmetal Alchemist, voluntarily had his left arm amputated and replaced with a machine gun/switchblade.
- Bao-Dur - Star Wars: Knights of the Old Republic II: The Sith Lords, left arm replaced by unique cybernetic prosthesis using repulsor technology.
- Beren - The Silmarillion, had one hand bitten off by a giant wolf.
- Jet Black - Cowboy Bebop, lost left arm in an attempt to capture assassin Udai Taxim, has a cybernetic replacement.
- Budai - Osamu Tezuka's Buddha, loses an arm and a leg to crocodiles
- Buddy Threadgoode, Jr. - Fried Green Tomatoes at the Whistle Stop Cafe, lost arm after being hit by a train
- Buster Bluth - Arrested Development, left hand bitten off at the wrist by a seal; replaced with a mechanical hook.
- Dr. Marvin Candle - Lost, while not demonstrated in his screentime, has a prosthetic right arm according to the show's producers.
- Phil Cassidy - Grand Theft Auto (series) Claims to have lost his arm fighting in Nicaragua, but actually lost it in a blast on his property while using explosives under the influence of homebrew liquor.
- Chantelle - appears in Elmore Leonard's novel Pagan Babies; she is the Rwandan housekeeper of Fr. Terry Dunn. She is missing her left arm, which was cut off with a machete during the Rwandan Genocide of 1994.
- Juan Chicoy, the bus driver in John Steinbeck's novel The Wayward Bus, is missing the first joint of one finger on his left hand.
- The Claw - Inspector Gadget; in the television series, no explanation was ever given; in the movie, he only lost his hand, and it was in an accident with a bowling ball.
- Cobra - Space Adventure Cobra, has left arm replaced by the Psychogun, which can transform to act as a normal hand.
- Corum - fictional character created by Michael Moorcock, cut off during torture.
- Thomas Covenant - fingers excised due to gangrene from leprosy.
- Colonel Daren - Red Dead Revolver video game, left arm at the shoulder is blown off by Red Harlow using his father's Scorpion gun.
- Roland Deschain - Stephen King's The Dark Tower series, loses two fingers on his right hand due to the lobstrosities at the beginning of The Drawing of the Three.
- Goldeneyes Silverhand Didactylos - Discworld, had his hand cut off after building the Palace of the Seven Deserts, apparently so he would not build anything better for someone else.
- Lieutenant Colonel Jean V. Dubois - Starship Troopers novel, retired from the Mobile Infantry after losing his arm, became Juan Rico's high school instructor in History and Moral Philosophy.
- Dyne - Final Fantasy VII video game, lost his left hand in the same incident that cost Barret Wallace his right hand: both of their hands were shot off while escaping Shinra troops. He had it replaced with a gun in a procedure similar to the one Barret received.
- Lady Eboshi - Princess Mononoke, arm was bitten off by wolf-god.
- Edward Elric - Fullmetal Alchemist, who lost his left leg in an alchemic ritual to revive his dead mother. Sacrificed his right arm to retrieve his brother's soul and bind it to a suit of armor. Has arm and leg later replaced by auto-mail (cybernetic) prosthetic.
- Edward Steam - Steamboy, right arm was badly scalded in steam-pipe explosion, and had to be amputated. Replaced it with a mechanical prosthesis of his own invention, which also functions as an ignition key for his Steam Castle.
- Fafhrd in the Rime Isle by Fritz Leiber loses a hand.
- Forge - X-Men, lost hand and leg in Vietnam.
- Lt. Col. Frank Archer - Fullmetal Alchemist, lost one arm, one leg, and much of the left side of his body in an alchemic reaction, and replaced all of it with automail. Most of his artificial limbs contain concealed weapons.
- Folken Fanel - Vision of Escaflowne, lost his right arm while attempting to slay a dragon as part of a rite of passage, and it was later replaced with a cybernetic one.
- Takuma Fudou - Get Backers anime and manga, lost his left arm and right eye in a confrontation with Ban Midou, has a cybernetic prosthetic with claws, but receives an arm transplant in the last arc of the anime.
- Phillip Michael Gerard a.k.a. Mike the One-Armed Man - Twin Peaks, Killer Bob's ex-familiar, removed his arm after being touched by the devilish one.
- Ned Gerblansky- South Park, lost half of his right arm in Vietnam
- Lewis Gillies - in Stephen R. Lawhead's Song of Albion (based on Llew Llaw Gyffes and Nuada)
- The Girl Without Hands- the titular Grimm's Fairy Tales character, her father cut off her hands under the threat of the Devil. In the end, by her virtue, God allows her hands to grow back.
- Royce Glas - Fear Effect videogame, in the course of the game Glas' left arm is dismembered by Lam.
- Guts - Berserk, cuts off his own left arm to escape from the maw of a demon, has a rather advanced, spring-loaded prosthesis built around a cannon.
- Tee Hee - James Bond villain in the film Live and Let Die, in which he used a mechanical hook for his lost hand, which he claims was lost to an alligator.
- Herman - The Simpsons
- Fleet Sergeant Ho - Starship Troopers novel, Federal Service recruiting officer who lost both his legs and his right arm in service to the Mobile Infantry. Wears prosthetic limbs off-duty, but takes them off while "on display".
- Honor Harrington - part of the Honorverse.
- Captain James Hook - Peter Pan, right hand cut off by Peter, which is then eaten by a crocodile.
- Inspector Kemp - Young Frankenstein, arm torn off by Victor Frankenstein's monster.
- KGBeast - DC Comics, severs own hand to escape capture. Replaced with device equipped with various weapons.
- Alex Krycek, in The X-Files, arm amputated by Russian villagers.
- Yakov Katzenlenbogen, of Pheonix Force. Right arm below elbow blown off in a middle-eastern war.
- Lavinia - Titus Andronicus, has both hands cut off during her rape by the Goth Queen's sons.
- Kelly Layzner - Gundam 0083, Zeon mobile suit pilot who lost his left arm in battle.
- Felix Leiter - James Bond - in the Bond novels (but not the films), Felix has a prosthetic mechanical claw after being mauled by a shark and consequently losing an arm and a leg in Live and Let Die. In the film series, he is fed to a shark in Licence to Kill, losing a leg only.
- Lex Luthor - DC Comics, left hand amputated and replaced with mechanical prosthetic after being irritated by excessive exposure to kryptonite radiation from stone placed in a signet ring. Later has entire body regrown.
- Lindsey, the Wolfram and Hart lawyer, whose hand is sliced off by Angel in the television series Angel. He later has it replaced through mystical means.
- Maedhros - The Silmarillion, has his right hand amputated in order to escape his bondage in Thangorodrim.
- The Mechanist - Avatar: The Last Airbender, lost four fingers while testing his "finger-safe" knife-sharpener, and replaced them with wooden ones strapped to the stumps.
- Mitsume, an assassin in the manga series The Demon Ororon, is missing one arm and several fingers on his remaining hand
- Roy Munson - Kingpin, the state bowling champion of 1979 until he had his hand mangled in a bowling ball return by street punks.
- Hauptmann Hermann Musk - Stalingrad, assumed to have lost left hand during combat prior to the Battle of Stalingrad, uses molded prosthetic hands to issue orders or use weapons.
- Nessarose Thropp, Wicked Witch of the East in Wicked (novel) by Gregory Maguire, born without arms.
- Dr. Julius No, villain in the James Bond books, both hands replaced by prosthetics
- Nuada of the Silver Hand in Irish- Celtic mythology
- Nym, Star Wars: Starfighter, mysteriously missing forearm replaced with cybernetic prosthesis.
- Nog, Star Trek: Deep Space Nine, lost his leg in battle against the Dominion.
- Revolver Ocelot - Metal Gear Solid series, right hand severed by Gray Fox. Later replaced with transplant from Liquid Snake.
- "The One-armed man" - killer of Dr. Richard Kimble's wife on the television series The Fugitive
- Meredith Peters a.k.a. "the Hook Lady" - Boston Public, lost her hand while escaping from her son.
- Chubbs Peterson - Happy Gilmore, lost his right hand to an alligator while trying to retrieve a golf ball, wears a plaster prosthetic.
- Peter Pettigrew - Harry Potter series, cuts off his own finger in order to fake his death after his betrayal of James and Lily Potter. Years later, he removes the remaining hand as part of a magical process to restore Voldemort's bodily form. Voldemort gives him a magical silver prosthesis as a replacement.
- Lieutenant Jean Rasczak - Starship Troopers film, assumed to have lost hand during Mobile Infantry service, uses cybernetic replacement when remobilized into active service.
- Risk - DC Comics' former Teen Titan was maimed in battle with Superboy-Prime in Infinite Crisis #4 ( 2006).
- Sauron, from the Middle-earth mythos, had a finger cut off by Isildur. In the film-version of Lord of the Rings, he had all the fingers on one hand cut off.
- Scar - Fullmetal Alchemist, arm was blown off by Zolf J. Kimblee, replaced with transplant from his brother.
- Seras Victoria - from the Hellsing manga, had an arm ripped off by Lt. Zorin Blitz. In place of the arm, swirling dark energy is seen.
- Sesshōmaru - Lost his arm in a battle with his younger brother InuYasha, who cut it off with the mystical sword Tessaiga.
- Shanks - One Piece, arm bitten off by sea-serpent.
- Shiba Kuukaku, Bleach - missing her right arm. The arm is amputated and wrapped in bandages in the manga, but is inexplicably replaced with a wooden arm in the anime adaptation.
- Mr. Shiftlet - from Flannery O'Connor's short story, The Life You Save May Be Your Own, lost his left arm.
- Shira - Blade of the Immortal, has his arm cut off by the immortal ronin Manji, later removes the flesh and sharpens the exposed bone into a weapon.
- Siamese - Kabuki, formerly conjoined twins, fused at the shoulder (some sources depict elbow). Detachable cybernetic arms have replaced the separation point.
- Laeral Silverhand of the Seven Sisters - Forgotten Realms, lost an arm in an attack by the minions of the phaerimm in the Return of the Archwizards Trilogy. She later re-grew it with the help of Khelben Arunsun.
- Skinner - one of Jupiter's rats in The Dark Portal, of the Deptford mice series by Robin Jarvis; has a 'peeler' (knife) attached to his stump, instead of an arm.
- Luke Skywalker - Star Wars series, hand severed in lightsaber duel with Darth Vader, replaced with a cybernetic prosthetic.
- Commandant Edwin Spangler - Malcolm in the Middle, commandant of Marlin Military Academy. Wears a hook as a replacement for his lost hand, as well as an artificial leg and eyepatch. At the beginning of the third season, Francis accidentally slices off his other hand after being gifted by Spangler with a ceremonial sword.
- Tetsuo, Akira, loses arm to a laser blast from an orbiting satellite, later telekinetically rebuilds a replacement from his flesh and surrounding steel.
- Nessarose Thropp, Wicked - Missing both arms. Written by Gregory Maguire
- Anton Tobias - lead role in the movie Idle Hands, played by Devon Sawa
- Tyr - god of warfare and battle in Norse mythology; hand bitten off by the Fenrisulfr
- Darth Traya - Star Wars: Knights of the Old Republic II: The Sith Lords, Left hand severed in duel with former apprentice Darth Sion.
- Vash the Stampede - Trigun, left arm blown off in a battle with his brother Millions Knives, replaced with artificial arm concealing a machine gun.
- Vecna - Dungeons and Dragons, hand severed when betrayed by his lieutenant Kas. The hand itself becomes a powerful magic relic. Also missing eye.
- Vera Black - Justice League Elite, lost arms in childhood incident, replaced with advanced cybernetics.
- Andrew Waltfeld - from Gundam Cosmic Era. Also lost a leg and an eye.
- Barret Wallace - from Final Fantasy VII video game (and Final Fantasy VII: Advent Children movie), lost his right hand while he and Dyne escaped a Shinra attack. Originally having a normal prosthetic, he had it replaced with a multi-barrelled gun.
- Will Parry - From His Dark Materials Series (The Subtle Knife, The Amber Spyglass). Loses last 2 fingers on his left hand fighting for the Subtle Knife. It is the mark of the Knife Bearer, which he then becomes.
- Wilt - Foster's Home for Imaginary Friends, has lost his right arm due to an unknown reason, and it is now a stitched-up stub.
- Yoshimitsu - Soul Calibur, lost his right arm due to the samurai lord Oda Nobunaga.
- Yasutora Sado - Bleach, lost his right arm in a battle against the arrancar Yammy, then it´s restored by Inoue Orihime.
- Zia Morlon - from Wet Moon, missing her left arm, lost in a car accident during her road test.
- Second Lieutenant Shiro Amada - Mobile Suit Gundam: The 08th MS Team, loses leg in battle with the experimental mobile armor Apsalus.
- Captain Ahab - Moby-Dick, lost leg to the eponymous whale.
- Colonel Steve Austin - The Six Million Dollar Man, lost both legs in test flight accident, in addition to right arm and left eye. Replaced by cybernetic implants provided by Office of Scientific Intelligence.
- B.D. - Doonesbury, lost leg in U.S.-led occupation of Iraq
- Jasper Beardley - The Simpsons
- Major(?) Joliot Comanche - Fullmetal Alchemist, lost leg in the Ishbal Rebellion, replaced it with a wooden peg.
- Larry Dever the hemihuman, from The Godwhale by T. J. Bass. Lost the lower part of his body (see Hemicorporectomy) and, being young, preferred cryostasis to such an existence.
- Edward Elric - Fullmetal Alchemist, lost his left leg while attempting to resurrect his mother, his brother lost his whole body. Automail replacement.
- Genevieve "Pronto" Tora - Angels 2200; has mechanical prosthetic
- Halfy - South Park
- Fleet Sergeant Ho - Starship Troopers novel, Federal Service recruiting officer who lost both his legs in service, in addition to his right arm. Wears prosthetic limbs off-duty, but takes them off while "on display".
- Sergeant Jelal - Starship Troopers novel, loses both legs in service with the Mobile Infantry.
- Major Lebedeen - cowardly US Marine who loses his foot after jumping ship and getting pulled underneath to the propellers in One of the Guys, novel by Robert Clark Young
- Felix Leiter - James Bond - In the film series, he is fed to a shark in Licence to Kill, losing a leg.
- Dr. Arliss Loveless - Wild Wild West (the movie); in the television series, Dr. Miguelito Loveless was a dwarf, but his appendages were all present.
- Group Captain Lionel Mandrake - Dr. Strangelove
- Lieutenant Commander Bud Roberts - JAG, lost his leg during a desperate attempt to save a child in an Afghan mine field
- Doc Robbins - CSI: Crime Scene Investigation coroner, has two prosthetic legs.
- Long John Silver - Treasure Island
- Captain William Storm ( DC Comics) - Lost his left leg during a sea battle in World War II.
- Dr. Eli Vance - Half-Life computer and video game series, lost his left leg while escaping the Black Mesa Research Facility, presumably to a bullsquid. In Half-Life 2, he wears a makeshift prosthetic.
- Zeff - One Piece, ate his right leg to survive when stranded on a deserted island for eighty days in the manga, cut his right leg off when it got trapped in ship debris in the anime. He now wears a peg.
- Armie - What It's Like Being Alone, no limbs, except for his left arm. He glides around on a skateboard, and often falls over when he uses his arm for something, like waving.
- The Black Knight Monty Python and The Holy Grail - had all limbs cut off by King Arthur
- Joe Bonham - Johnny Got His Gun, lost all four limbs and his face from artillery explosion.
- Nana -- Elfen Lied, had all of her limbs torn off by Lucy. Later receives prosthetic limbs from Director Kurama.
- Christopher Pike -- Former captain of the USS Enterprise. Lost the use of almost all his body due to delta radiation. Featured in the Star Trek episode " The Menagerie" he is confined to a wheelchair that allows him to answer "yes or no" questions by displaying lights of different colors.
- Shiro Sanda (Stephen Sandor) - Space Battleship Yamato (Star Blazers), lost limbs in a rocket car accident in his childhood, has bionic replacements.
- "Threeparts" Scallot Discworld (Monstrous Regiment), Borogravian soldier missing both legs, an arm, and an eye.
- Anakin Skywalker/Darth Vader - Star Wars series, right arm first severed in lightsaber duel with Count Dooku. Later loses left arm and both legs in a duel with Obi-Wan Kenobi. All replaced with cybernetic prosthetics. Additionally, Vader lost one of his cybernetic replacements in battle with his son, Luke Skywalker.
- Titus Andronicus - Titus Andronicus, has his hand cut off by Aaron.
- Aquaman - DC Comics, hand lost in various different manners (depending on the series) and replaced with a harpoon head (later an advanced cybernetically-controlled version of the same) and eventually with a hand-shaped field of water.
- Ash - " Evil Dead" trilogy, amputates right hand after it becomes possessed by the evil "Deadite" force, replaces it with a chainsaw mounted to his wrist and later, a mechanical prosthetic metal hand.
- Colonel Steve Austin - The Six Million Dollar Man and the book Cyborg by Martin Caidin, lost right arm in test flight accident, in addition to both legs and left eye. Replaced by cybernetic implants provided by Office of Scientific Intelligence.
- Bink - Xanth, cut off finger in childhood playing with a large knife. Restored later by a healing spring.
- Frodo Baggins - The Lord of the Rings, had a finger bitten off by Gollum.
- Baiken - Guilty Gear, lost her right arm and left eye in a Gear attack on Japan.
- Bald - Fullmetal Alchemist, voluntarily had his left arm amputated and replaced with a machine gun/switchblade.
- Bao-Dur - Star Wars: Knights of the Old Republic II: The Sith Lords, left arm replaced by unique cybernetic prosthesis using repulsor technology.
- Beren - The Silmarillion, had one hand bitten off by a giant wolf.
- Jet Black - Cowboy Bebop, lost left arm in an attempt to capture assassin Udai Taxim, has a cybernetic replacement.
- Budai - Osamu Tezuka's Buddha, loses an arm and a leg to crocodiles
- Buddy Threadgoode, Jr. - Fried Green Tomatoes at the Whistle Stop Cafe, lost arm after being hit by a train
- Buster Bluth - Arrested Development, left hand bitten off at the wrist by a seal; replaced with a mechanical hook.
- Dr. Marvin Candle - Lost, while not demonstrated in his screentime, has a prosthetic right arm according to the show's producers.
- Phil Cassidy - Grand Theft Auto (series) Claims to have lost his arm fighting in Nicaragua, but actually lost it in a blast on his property while using explosives under the influence of homebrew liquor.
- Chantelle - appears in Elmore Leonard's novel Pagan Babies; she is the Rwandan housekeeper of Fr. Terry Dunn. She is missing her left arm, which was cut off with a machete during the Rwandan Genocide of 1994.
- Juan Chicoy, the bus driver in John Steinbeck's novel The Wayward Bus, is missing the first joint of one finger on his left hand.
- The Claw - Inspector Gadget; in the television series, no explanation was ever given; in the movie, he only lost his hand, and it was in an accident with a bowling ball.
- Cobra - Space Adventure Cobra, has left arm replaced by the Psychogun, which can transform to act as a normal hand.
- Corum - fictional character created by Michael Moorcock, cut off during torture.
- Thomas Covenant - fingers excised due to gangrene from leprosy.
- Colonel Daren - Red Dead Revolver video game, left arm at the shoulder is blown off by Red Harlow using his father's Scorpion gun.
- Roland Deschain - Stephen King's The Dark Tower series, loses two fingers on his right hand due to the lobstrosities at the beginning of The Drawing of the Three.
- Goldeneyes Silverhand Didactylos - Discworld, had his hand cut off after building the Palace of the Seven Deserts, apparently so he would not build anything better for someone else.
- Lieutenant Colonel Jean V. Dubois - Starship Troopers novel, retired from the Mobile Infantry after losing his arm, became Juan Rico's high school instructor in History and Moral Philosophy.
- Dyne - Final Fantasy VII video game, lost his left hand in the same incident that cost Barret Wallace his right hand: both of their hands were shot off while escaping Shinra troops. He had it replaced with a gun in a procedure similar to the one Barret received.
- Lady Eboshi - Princess Mononoke, arm was bitten off by wolf-god.
- Edward Elric - Fullmetal Alchemist, who lost his left leg in an alchemic ritual to revive his dead mother. Sacrificed his right arm to retrieve his brother's soul and bind it to a suit of armor. Has arm and leg later replaced by auto-mail (cybernetic) prosthetic.
- Edward Steam - Steamboy, right arm was badly scalded in steam-pipe explosion, and had to be amputated. Replaced it with a mechanical prosthesis of his own invention, which also functions as an ignition key for his Steam Castle.
- Fafhrd in the Rime Isle by Fritz Leiber loses a hand.
- Forge - X-Men, lost hand and leg in Vietnam.
- Lt. Col. Frank Archer - Fullmetal Alchemist, lost one arm, one leg, and much of the left side of his body in an alchemic reaction, and replaced all of it with automail. Most of his artificial limbs contain concealed weapons.
- Folken Fanel - Vision of Escaflowne, lost his right arm while attempting to slay a dragon as part of a rite of passage, and it was later replaced with a cybernetic one.
- Takuma Fudou - Get Backers anime and manga, lost his left arm and right eye in a confrontation with Ban Midou, has a cybernetic prosthetic with claws, but receives an arm transplant in the last arc of the anime.
- Phillip Michael Gerard a.k.a. Mike the One-Armed Man - Twin Peaks, Killer Bob's ex-familiar, removed his arm after being touched by the devilish one.
- Ned Gerblansky- South Park, lost half of his right arm in Vietnam
- Lewis Gillies - in Stephen R. Lawhead's Song of Albion (based on Llew Llaw Gyffes and Nuada)
- The Girl Without Hands- the titular Grimm's Fairy Tales character, her father cut off her hands under the threat of the Devil. In the end, by her virtue, God allows her hands to grow back.
- Royce Glas - Fear Effect videogame, in the course of the game Glas' left arm is dismembered by Lam.
- Guts - Berserk, cuts off his own left arm to escape from the maw of a demon, has a rather advanced, spring-loaded prosthesis built around a cannon.
- Tee Hee - James Bond villain in the film Live and Let Die, in which he used a mechanical hook for his lost hand, which he claims was lost to an alligator.
- Herman - The Simpsons
- Fleet Sergeant Ho - Starship Troopers novel, Federal Service recruiting officer who lost both his legs and his right arm in service to the Mobile Infantry. Wears prosthetic limbs off-duty, but takes them off while "on display".
- Honor Harrington - part of the Honorverse.
- Captain James Hook - Peter Pan, right hand cut off by Peter, which is then eaten by a crocodile.
- Inspector Kemp - Young Frankenstein, arm torn off by Victor Frankenstein's monster.
- KGBeast - DC Comics, severs own hand to escape capture. Replaced with device equipped with various weapons.
- Alex Krycek, in The X-Files, arm amputated by Russian villagers.
- Yakov Katzenlenbogen, of Pheonix Force. Right arm below elbow blown off in a middle-eastern war.
- Lavinia - Titus Andronicus, has both hands cut off during her rape by the Goth Queen's sons.
- Kelly Layzner - Gundam 0083, Zeon mobile suit pilot who lost his left arm in battle.
- Felix Leiter - James Bond - in the Bond novels (but not the films), Felix has a prosthetic mechanical claw after being mauled by a shark and consequently losing an arm and a leg in Live and Let Die. In the film series, he is fed to a shark in Licence to Kill, losing a leg only.
- Lex Luthor - DC Comics, left hand amputated and replaced with mechanical prosthetic after being irritated by excessive exposure to kryptonite radiation from stone placed in a signet ring. Later has entire body regrown.
- Lindsey, the Wolfram and Hart lawyer, whose hand is sliced off by Angel in the television series Angel. He later has it replaced through mystical means.
- Maedhros - The Silmarillion, has his right hand amputated in order to escape his bondage in Thangorodrim.
- The Mechanist - Avatar: The Last Airbender, lost four fingers while testing his "finger-safe" knife-sharpener, and replaced them with wooden ones strapped to the stumps.
- Mitsume, an assassin in the manga series The Demon Ororon, is missing one arm and several fingers on his remaining hand
- Roy Munson - Kingpin, the state bowling champion of 1979 until he had his hand mangled in a bowling ball return by street punks.
- Hauptmann Hermann Musk - Stalingrad, assumed to have lost left hand during combat prior to the Battle of Stalingrad, uses molded prosthetic hands to issue orders or use weapons.
- Nessarose Thropp, Wicked Witch of the East in Wicked (novel) by Gregory Maguire, born without arms.
- Dr. Julius No, villain in the James Bond books, both hands replaced by prosthetics
- Nuada of the Silver Hand in Irish- Celtic mythology
- Nym, Star Wars: Starfighter, mysteriously missing forearm replaced with cybernetic prosthesis.
- Nog, Star Trek: Deep Space Nine, lost his leg in battle against the Dominion.
- Revolver Ocelot - Metal Gear Solid series, right hand severed by Gray Fox. Later replaced with transplant from Liquid Snake.
- "The One-armed man" - killer of Dr. Richard Kimble's wife on the television series The Fugitive
- Meredith Peters a.k.a. "the Hook Lady" - Boston Public, lost her hand while escaping from her son.
- Chubbs Peterson - Happy Gilmore, lost his right hand to an alligator while trying to retrieve a golf ball, wears a plaster prosthetic.
- Peter Pettigrew - Harry Potter series, cuts off his own finger in order to fake his death after his betrayal of James and Lily Potter. Years later, he removes the remaining hand as part of a magical process to restore Voldemort's bodily form. Voldemort gives him a magical silver prosthesis as a replacement.
- Lieutenant Jean Rasczak - Starship Troopers film, assumed to have lost hand during Mobile Infantry service, uses cybernetic replacement when remobilized into active service.
- Risk - DC Comics' former Teen Titan was maimed in battle with Superboy-Prime in Infinite Crisis #4 ( 2006).
- Sauron, from the Middle-earth mythos, had a finger cut off by Isildur. In the film-version of Lord of the Rings, he had all the fingers on one hand cut off.
- Scar - Fullmetal Alchemist, arm was blown off by Zolf J. Kimblee, replaced with transplant from his brother.
- Seras Victoria - from the Hellsing manga, had an arm ripped off by Lt. Zorin Blitz. In place of the arm, swirling dark energy is seen.
- Sesshōmaru - Lost his arm in a battle with his younger brother InuYasha, who cut it off with the mystical sword Tessaiga.
- Shanks - One Piece, arm bitten off by sea-serpent.
- Shiba Kuukaku, Bleach - missing her right arm. The arm is amputated and wrapped in bandages in the manga, but is inexplicably replaced with a wooden arm in the anime adaptation.
- Mr. Shiftlet - from Flannery O'Connor's short story, The Life You Save May Be Your Own, lost his left arm.
- Shira - Blade of the Immortal, has his arm cut off by the immortal ronin Manji, later removes the flesh and sharpens the exposed bone into a weapon.
- Siamese - Kabuki, formerly conjoined twins, fused at the shoulder (some sources depict elbow). Detachable cybernetic arms have replaced the separation point.
- Laeral Silverhand of the Seven Sisters - Forgotten Realms, lost an arm in an attack by the minions of the phaerimm in the Return of the Archwizards Trilogy. She later re-grew it with the help of Khelben Arunsun.
- Skinner - one of Jupiter's rats in The Dark Portal, of the Deptford mice series by Robin Jarvis; has a 'peeler' (knife) attached to his stump, instead of an arm.
- Luke Skywalker - Star Wars series, hand severed in lightsaber duel with Darth Vader, replaced with a cybernetic prosthetic.
- Commandant Edwin Spangler - Malcolm in the Middle, commandant of Marlin Military Academy. Wears a hook as a replacement for his lost hand, as well as an artificial leg and eyepatch. At the beginning of the third season, Francis accidentally slices off his other hand after being gifted by Spangler with a ceremonial sword.
- Tetsuo, Akira, loses arm to a laser blast from an orbiting satellite, later telekinetically rebuilds a replacement from his flesh and surrounding steel.
- Nessarose Thropp, Wicked - Missing both arms. Written by Gregory Maguire
- Anton Tobias - lead role in the movie Idle Hands, played by Devon Sawa
- Tyr - god of warfare and battle in Norse mythology; hand bitten off by the Fenrisulfr
- Darth Traya - Star Wars: Knights of the Old Republic II: The Sith Lords, Left hand severed in duel with former apprentice Darth Sion.
- Vash the Stampede - Trigun, left arm blown off in a battle with his brother Millions Knives, replaced with artificial arm concealing a machine gun.
- Vecna - Dungeons and Dragons, hand severed when betrayed by his lieutenant Kas. The hand itself becomes a powerful magic relic. Also missing eye.
- Vera Black - Justice League Elite, lost arms in childhood incident, replaced with advanced cybernetics.
- Andrew Waltfeld - from Gundam Cosmic Era. Also lost a leg and an eye.
- Barret Wallace - from Final Fantasy VII video game (and Final Fantasy VII: Advent Children movie), lost his right hand while he and Dyne escaped a Shinra attack. Originally having a normal prosthetic, he had it replaced with a multi-barrelled gun.
- Will Parry - From His Dark Materials Series (The Subtle Knife, The Amber Spyglass). Loses last 2 fingers on his left hand fighting for the Subtle Knife. It is the mark of the Knife Bearer, which he then becomes.
- Wilt - Foster's Home for Imaginary Friends, has lost his right arm due to an unknown reason, and it is now a stitched-up stub.
- Yoshimitsu - Soul Calibur, lost his right arm due to the samurai lord Oda Nobunaga.
- Yasutora Sado - Bleach, lost his right arm in a battle against the arrancar Yammy, then it´s restored by Inoue Orihime.
- Zia Morlon - from Wet Moon, missing her left arm, lost in a car accident during her road test.
- Second Lieutenant Shiro Amada - Mobile Suit Gundam: The 08th MS Team, loses leg in battle with the experimental mobile armor Apsalus.
- Captain Ahab - Moby-Dick, lost leg to the eponymous whale.
- Colonel Steve Austin - The Six Million Dollar Man, lost both legs in test flight accident, in addition to right arm and left eye. Replaced by cybernetic implants provided by Office of Scientific Intelligence.
- B.D. - Doonesbury, lost leg in U.S.-led occupation of Iraq
- Jasper Beardley - The Simpsons
- Major(?) Joliot Comanche - Fullmetal Alchemist, lost leg in the Ishbal Rebellion, replaced it with a wooden peg.
- Larry Dever the hemihuman, from The Godwhale by T. J. Bass. Lost the lower part of his body (see Hemicorporectomy) and, being young, preferred cryostasis to such an existence.
- Edward Elric - Fullmetal Alchemist, lost his left leg while attempting to resurrect his mother, his brother lost his whole body. Automail replacement.
- Genevieve "Pronto" Tora - Angels 2200; has mechanical prosthetic
- Halfy - South Park
- Fleet Sergeant Ho - Starship Troopers novel, Federal Service recruiting officer who lost both his legs in service, in addition to his right arm. Wears prosthetic limbs off-duty, but takes them off while "on display".
- Sergeant Jelal - Starship Troopers novel, loses both legs in service with the Mobile Infantry.
- Major Lebedeen - cowardly US Marine who loses his foot after jumping ship and getting pulled underneath to the propellers in One of the Guys, novel by Robert Clark Young
- Felix Leiter - James Bond - In the film series, he is fed to a shark in Licence to Kill, losing a leg.
- Dr. Arliss Loveless - Wild Wild West (the movie); in the television series, Dr. Miguelito Loveless was a dwarf, but his appendages were all present.
- Group Captain Lionel Mandrake - Dr. Strangelove
- Lieutenant Commander Bud Roberts - JAG, lost his leg during a desperate attempt to save a child in an Afghan mine field
- Doc Robbins - CSI: Crime Scene Investigation coroner, has two prosthetic legs.
- Long John Silver - Treasure Island
- Captain William Storm ( DC Comics) - Lost his left leg during a sea battle in World War II.
- Dr. Eli Vance - Half-Life computer and video game series, lost his left leg while escaping the Black Mesa Research Facility, presumably to a bullsquid. In Half-Life 2, he wears a makeshift prosthetic.
- Zeff - One Piece, ate his right leg to survive when stranded on a deserted island for eighty days in the manga, cut his right leg off when it got trapped in ship debris in the anime. He now wears a peg.
- Armie - What It's Like Being Alone, no limbs, except for his left arm. He glides around on a skateboard, and often falls over when he uses his arm for something, like waving.
- The Black Knight Monty Python and The Holy Grail - had all limbs cut off by King Arthur
- Joe Bonham - Johnny Got His Gun, lost all four limbs and his face from artillery explosion.
- Nana -- Elfen Lied, had all of her limbs torn off by Lucy. Later receives prosthetic limbs from Director Kurama.
- Christopher Pike -- Former captain of the USS Enterprise. Lost the use of almost all his body due to delta radiation. Featured in the Star Trek episode " The Menagerie" he is confined to a wheelchair that allows him to answer "yes or no" questions by displaying lights of different colors.
- Shiro Sanda (Stephen Sandor) - Space Battleship Yamato (Star Blazers), lost limbs in a rocket car accident in his childhood, has bionic replacements.
- "Threeparts" Scallot Discworld (Monstrous Regiment), Borogravian soldier missing both legs, an arm, and an eye.
- Anakin Skywalker/Darth Vader - Star Wars series, right arm first severed in lightsaber duel with Count Dooku. Later loses left arm and both legs in a duel with Obi-Wan Kenobi. All replaced with cybernetic prosthetics. Additionally, Vader lost one of his cybernetic replacements in battle with his son, Luke Skywalker.