Acetyltransferase (or transacetylase) is a type of transferase enzyme that transfers an acetyl group, through a process called acetylation. Acetylation serves as a modification that can profoundly transform the functionality of a protein by modifying various properties like hydrophobicity, solubility, and surface attributes [1]. These alterations have the potential to influence the protein's conformation and its interactions with substrates, cofactors, and other macromolecules [1]. The image to the right shows the basic structure of an acetyl group, where R is a variable indicates the remainder of the molecule to which the acetyl group is attached.
Acetyltransferases | Substrate | Gene | Chromosome Location | Gene Group | Abbreviation |
Histone Acetyltransferase | Lysine residues on histones [1] | HAT1 [2] | 2q31.1 [2] | Lysine acetyltransferases [2] | HAT |
Choline Acetyltransferase | Choline [3] | CHAT [4] | 10q11.23 [4] | NA | ChAT [3] |
Serotonin N-Acetyltransferase | Serotonin | AANAT [5] | 17q25.1 [5] | GCN5 Related N-Acetyltransferases [5] | AANAT [5] |
NatA Acetyltransferase | N-terminus of various proteins as they emerge from the ribosome | NAA15 [6] | 4q31.1 [6] | Armadillo like helical domain containing
N-alpha-acetyltransferase subunits [6] |
NatA [6] |
NatB Acetyltransferase | Peptides starting with Met-Asp/Glu/Asn/Gln [7] | NAA25 [8] | 12q24.13 [8] | N-alpha-acetyltransferase subunits
MicroRNA protein coding host genes [8] |
NatB [8] |
The 3D structure predictions of histone, choline, and serotonin acetyltransferases are shown to the side of this page. The 3D structure of these proteins are essential for interactions between them and their substrates. Alterations to the 3D structures of these enzymes could result in the chemical modifications not being completed.
Additional examples include:
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Acetyltransferase (or transacetylase) is a type of transferase enzyme that transfers an acetyl group, through a process called acetylation. Acetylation serves as a modification that can profoundly transform the functionality of a protein by modifying various properties like hydrophobicity, solubility, and surface attributes [1]. These alterations have the potential to influence the protein's conformation and its interactions with substrates, cofactors, and other macromolecules [1]. The image to the right shows the basic structure of an acetyl group, where R is a variable indicates the remainder of the molecule to which the acetyl group is attached.
Acetyltransferases | Substrate | Gene | Chromosome Location | Gene Group | Abbreviation |
Histone Acetyltransferase | Lysine residues on histones [1] | HAT1 [2] | 2q31.1 [2] | Lysine acetyltransferases [2] | HAT |
Choline Acetyltransferase | Choline [3] | CHAT [4] | 10q11.23 [4] | NA | ChAT [3] |
Serotonin N-Acetyltransferase | Serotonin | AANAT [5] | 17q25.1 [5] | GCN5 Related N-Acetyltransferases [5] | AANAT [5] |
NatA Acetyltransferase | N-terminus of various proteins as they emerge from the ribosome | NAA15 [6] | 4q31.1 [6] | Armadillo like helical domain containing
N-alpha-acetyltransferase subunits [6] |
NatA [6] |
NatB Acetyltransferase | Peptides starting with Met-Asp/Glu/Asn/Gln [7] | NAA25 [8] | 12q24.13 [8] | N-alpha-acetyltransferase subunits
MicroRNA protein coding host genes [8] |
NatB [8] |
The 3D structure predictions of histone, choline, and serotonin acetyltransferases are shown to the side of this page. The 3D structure of these proteins are essential for interactions between them and their substrates. Alterations to the 3D structures of these enzymes could result in the chemical modifications not being completed.
Additional examples include:
![]() | This is the sandbox page where you will draft your initial Wikipedia contribution.
If you're starting a new article, you can develop it here until it's ready to go live. If you're working on improvements to an existing article, copy only one section at a time of the article to this sandbox to work on, and be sure to use an edit summary linking to the article you copied from. Do not copy over the entire article. You can find additional instructions here. Remember to save your work regularly using the "Publish page" button. (It just means 'save'; it will still be in the sandbox.) You can add bold formatting to your additions to differentiate them from existing content. |
{{
cite journal}}
: CS1 maint: PMC format (
link)
{{
cite journal}}
: CS1 maint: PMC format (
link)