National routes

• N1: Cape Town – Worcester – Beaufort West – Bloemfontein – Kroonstad – Johannesburg – Pretoria – Mokopane – Polokwane – Louis Trichardt – Beit Bridge (– A4 to Harare, Zimbabwe)
• N2: Cape Town – Caledon – Mossel Bay – George – Port Elizabeth – Grahamstown – King William's Town – East London – Mthatha – Kokstad – Port Shepstone – Durban – KwaDukuza – Empangeni – Ermelo
• N3: Durban – Pietermaritzburg – Harrismith – Heidelberg (GP) – Johannesburg
• N4: ( A2 from Lobatse, Botswana –) Skilpadshek – Rustenburg – Pretoria – eMalahleni – Middelburg (MP) – Nelspruit – Komatipoort (– EN4 to Maputo, Mozambique)
• N5: Winburg – Bethlehem – Harrismith
• N6: East London – Queenstown – Aliwal North – Bloemfontein
• N7: Cape Town – Malmesbury – Springbok – Vioolsdrif (– B1 to Windhoek, Namibia)
• N8: Groblershoop – Kimberley – Bloemfontein – Botshabelo – Maseru Bridge (– to Maseru, Lesotho)
• N9: George – Graaff-Reinet – Middelburg (EC) – Colesberg
• N10: Port Elizabeth – Cradock – Middelburg (EC) – De Aar – Prieska – Upington – Nakop (– B3 to Keetmanshoop, Namibia)
• N11: Ladysmith – Newcastle – Ermelo – Middelburg (MP) – Mokopane – Grobler's Bridge (– B140 to Palapye, Botswana)
• N12: George – Oudtshoorn – Beaufort West – Kimberley – Klerksdorp – Potchefstroom – Johannesburg – eMalahleni
• N14: Springbok – Upington – Kuruman – Vryburg – Krugersdorp – Pretoria
• N17: Johannesburg – Secunda – Ermelo – Ngwenya (– MR3 to Mbabane, Swaziland)
• N18: Warrenton – Vryburg – Mahikeng – Ramatlabama (– A1 to Lobatse, Botswana)

Provincial routes

• R21: Boksburg – Kempton Park – Centurion – Pretoria
• R22: Hluhluwe – Kosi Bay (– to Ponta do Ouro, Mozambique)
• R23: Volksrust – Standerton – Heidelberg (GP) – Brakpan – Benoni – Kempton Park
• R24: Rustenburg – Krugersdorp – Roodepoort – Johannesburg – Bedfordview – Kempton Park
• R25: Johannesburg – Kempton Park – Bronkhorstspruit – Groblersdal
• R26: Rouxville – Ladybrand – Ficksburg – Bethlehem – Reitz – Frankfort – Villiers
• R27 Southern section: Cape Town – Velddrif; Northern section: Vredendal – Calvinia – Keimoes
• R28: Vereeniging – Sebokeng – Westonaria – Randfontein – Krugersdorp
• R29: Johannesburg – Germiston – Boksburg – Benoni – Springs – Leandra – Kinross
• R30: Bloemfontein – Welkom – Odendaalsrus – Bothaville – Orkney – Klerksdorp – Ventersdorp – Rustenburg
• R31: ( C16 from Keetmanshoop, Namibia –) Rietfontein – Kuruman – Kimberley
• R33: Pietermaritzburg – Greytown – Dundee – Vryheid – eMkhondo – Carolina – eMakhazeni – Groblersdal – Marble Hall – Modimolle – Lephalale
• R34: Vryburg – Schweizer-Reneke – Bloemhof – Odendaalsrus – Kroonstad – Heilbron – Frankfort – Newcastle – Utrecht – Vryheid – Ulundi – Empangeni – Richards Bay
• R35: Amersfoort – Bethal – Middelburg (MP)
• R36: Ermelo – Carolina – Mashishing – Tzaneen – Louis Trichardt
• R37: Polokwane – Mashishing – Nelspruit
• R38: Standerton – Bethal – Carolina – Barberton – Kaapmuiden
• R39: Standerton – Ermelo
• R40: ( MR20 from Piggs Peak, Swaziland –) Bulembu – Barberton – Nelspruit – White River – Hoedspruit – Phalaborwa
• R41: Randfontein – Roodepoort – Johannesburg
• R42: Parys – Vanderbijlpark – Vereeniging – Heidelberg (GP) – Nigel – Delmas – Bronkhorstspruit
• R43: Gansbaai – Hermanus – Worcester – Ceres
• R44: Kleinmond – Strand – Somerset West – Stellenbosch – Wellington – Piketberg
• R45: Saldanha – Vredenburg – Malmesbury – Wellington – Paarl – Villiersdorp
• R46: Malmesbury – Ceres – Touws River
• R48: De Aar – Petrusburg
• R49: Mahikeng – Zeerust – Kopfontein (– A12 to Gaborone, Botswana)
• R50: Standerton – Leandra – Delmas – Pretoria
• R51: Villiers – Balfour – Nigel – Springs – Bapsfontein
• R52: Vryburg – Lichtenburg – Rustenburg
• R53: Parys – Potchefstroom – Ventersdorp – Swartruggens
• R54: Potchefstroom – Vereeniging – Villiers
• R55: Sandton – Pretoria
• R56: Middelburg (EC) – Molteno – Elliot – Matatiele – Kokstad – Pietermaritzburg
• R57: Phuthaditjhaba – Reitz – Heilbron – Sasolburg – Vanderbijlpark
• R58: Colesberg – Burgersdorp – Aliwal North – Barkly East – Ngcobo
• R59: Dealesville – Bothaville – Parys – Sasolburg – Vereeniging – Meyerton – Johannesburg
• R60: Worcester – Robertson – Swellendam
• R61: Beaufort West – Graaff-Reinet – Cradock – Queenstown – Mthatha – Port Edward – Margate – Port Shepstone
• R62: Ashton – Oudtshoorn – Humansdorp
• R63: Calvinia – Carnarvon – Graaff-Reinet – Fort Beaufort – King William's Town – Komga
• R64: Kimberley – Boshof – Bloemfontein
• R65: Ermelo – Sandlane (– MR19 to Manzini, Swaziland)
• R66: Gingindlovu – Eshowe – Ulundi – Nongoma – Pongola
• R67: Port Alfred – Grahamstown – Fort Beaufort – Queenstown
• R68: Dundee – Melmoth
• R69: Vryheid – Mkuze
• R70: Odendaalsrus – Hennenman – Senekal – Ficksburg
• R71: Polokwane – Tzaneen – Namakgale – Phalaborwa
• R72: Port Elizabeth – Port Alfred – East London
• R73: Winburg – Virginia – Welkom
• R74: Harrismith – Bergville – Greytown – KwaDukuza
• R75: Port Elizabeth – Uitenhage – Graaff-Reinet
• R76: Orkney – Kroonstad – Bethlehem
• R80: Pretoria – Soshanguve
• R81: Polokwane – Giyani – Thohoyandou
• R82: Kroonstad – Vereeniging – Johannesburg

Regional routes

100 series

• R101 Section 1: Bellville – Paarl – Worcester; Section 2: Sandton – Centurion – Pretoria – Hammanskraal – Bela-Bela – Modimolle – Mookgophong – Mokopane – Polokwane
• R102 Section 1: Cape Town – Somerset West; Section 2: Mossel Bay – George; Section 3: Grootrivier Pass through Nature's Valley; Section 4: Stormsrivier – Humansdorp – Jeffrey's Bay – Port Elizabeth – Colchester; Section 5: King William's Town – East London; Section 6: Port Shepstone – Scottburgh – Winklespruit – Kingsburgh – Amanzimtoti – Durban – Verulam – Tongaat – KwaDukuza – Mandeni – Empangeni
• R103 Section 1: Kloof – Pietermaritzburg – Howick – Mooi River – Estcourt – Ladysmith; Section 2: Warden – Villiers; Section 3: Heidelberg (GP) – Johannesburg
• R104 Section 1: Rustenburg – Hartbeespoort – Pretoria – Bronkhorstspruit; Section 2: Middelburg (MP) – Wonderfontein; Section 3: Samora Machel Drive through Nelspruit
• R114: Krugersdorp – Centurion

300 and 400 series

• R300: Mitchell's Plain – Brackenfell
• R301: Wemmershoek – Paarl – Wellington – R43 near Wolseley
• R302: Bellville – Durbanville – Malmesbury
• R303: Ceres – Citrusdal
• R304: Atlantis – Klipheuwel – Stellenbosch
• R305: N2 near Riversdale – Stilbaai
• R306: N9 near Willowmore – R61 near Beaufort West
• R307: Atlantis – Darling – R45
• R308: R356 near Fraserburg – R63 near Carnarvon
• R309: N8 – Postmasburg
• R310: Muizenberg – Mitchell's Plain – Stellenbosch – R45
• R311: R45 near Hopefield – Moorreesburg – Riebeek-Kasteel
• R312: Fisantekraal – R44
• R313: Prieska – Griekwastad
• R315: Yzerfontein – Darling – Malmesbury
• R316: Caledon – Bredasdorp – Arniston
• R317: Bredasdorp – Bonnievale – Robertson
• R318: Montagu – N1 near Touws River
• R319: Struisbaai – Bredasdorp – N2 near Swellendam
• R320: Hermanus – Caledon
• R321: Grabouw – R45 near Villiersdorp
• R322: Witsand – Heidelberg (WC) – R324 near Suurbraak
• R323: Riversdale – R62 near Ladismith
• R324: Witsand – Barrydale
• R325: Griekwastad – Postmasburg – Kathu
• R326: Stanford – N2 near Riviersonderend
• R327: N2 near Mossel Bay – R62 near Ladismith
• R328: Mossel Bay – Oudtshoorn – Cango Caves
• R329: Willowmore – Steytlerville – R75
• R330: Cape St. Francis – Humansdorp – Hankey
• R331: R332 near Patensie – Patensie – N2 exit 702
• R332: R331 near Patensie – R330 near Humansdorp
• R334: R102 west of Port Elizabeth – Uitenhage – R102 at Coega
• R335: Motherwell – Addo – Somerset East
• R336: R75 – Kirkwood – Addo
• R337: R329 near Willowmore – Jansenville – Cradock
• R338: Aberdeen – R329 near Steytlerville
• R339: Knysna – Uniondale – R341
• R340: N2 – R339
• R341: De Rust – N9
• R342: R335 near Addo – Paterson – N2
• R343: Kenton-on-Sea – N2 near Grahamstown
• R344: R350 near Grahamstown – Adelaide – Tarkastad – R56 near Dordrecht
• R345: R72 near Bell – Alice – Cathcart
• R346: Stutterheim – King William's Town – East London
• R347: R346 – R72 near Kidd's Beach
• R349: N2 – Kei Mouth

500 series

600 series

700 series

References

• Falkner, John (May 2012). South African Numbered Route Description and Destination Analysis (Report). National Department of Transport. pp. 1–6. Retrieved 31 August 2014.