EEA1 is a RAB5A effector protein which binds via an N-terminal zinc finger domain and is required for fusion of early and late endosomes and for sorting at the early endosome level.
EEA1 plays a role in endocytosis and is recruited by Rab5-GTP to endosomal membranes [1]. EEA1 may be regulated through monoubiquination, affecting endosome fusion and trafficking [2]. Ubiquitin selective segregase p97 may regulate EEA1's tethering ability, affecting its endosome trafficking and morphplogy.
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EEA1 is a RAB5A effector protein which binds via an N-terminal zinc finger domain and is required for fusion of early and late endosomes and for sorting at the early endosome level.
EEA1 plays a role in endocytosis and is recruited by Rab5-GTP to endosomal membranes [1]. EEA1 may be regulated through monoubiquination, affecting endosome fusion and trafficking [2]. Ubiquitin selective segregase p97 may regulate EEA1's tethering ability, affecting its endosome trafficking and morphplogy.
This is the sandbox page where you will draft your initial Wikipedia contribution.
If you're starting a new article, you can develop it here until it's ready to go live. If you're working on improvements to an existing article, copy only one section at a time of the article to this sandbox to work on, and be sure to use an edit summary linking to the article you copied from. Do not copy over the entire article. You can find additional instructions here. Remember to save your work regularly using the "Publish page" button. (It just means 'save'; it will still be in the sandbox.) You can add bold formatting to your additions to differentiate them from existing content. |
{{
cite journal}}
: CS1 maint: unflagged free DOI (
link)