Header: Pharmacology
Subheader: Excretion
Due to the large propensity of THC and CBD being hepatically metabolized, a greater proportion of metabolites are excreted via feces than in the urine. [1]
After delta-9-THC is hydroxylated into 11-OH-THC via CYP2C9, CYP2C19, and CYP3A4, it undergoes phase II metabolism into more than 30 metabolites. A majority of these metabolites are products of glucuronidation. Approximately 65% is excreted in feces and 25% in the urine, while the remaining 10% is excreted not in feces or urine. [1] The terminal half-life is approximately 25-36 hours. [2]
CBD is hydroxylated by P450 liver enzymes into 7-OH-CBD. Its metabolites are products of primarily CYP2C19 and CYP3A4 activity, with potential activity of CYP1A1, CYP1A2, CYP2C9, and CYP2D6. [3] Similar to delta-9-THC, a majority of CBD is excreted in feces and some in the urine. [1] The terminal half-life is approximately 18-32 hours. [4]
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Header: Pharmacology
Subheader: Excretion
Due to the large propensity of THC and CBD being hepatically metabolized, a greater proportion of metabolites are excreted via feces than in the urine. [1]
After delta-9-THC is hydroxylated into 11-OH-THC via CYP2C9, CYP2C19, and CYP3A4, it undergoes phase II metabolism into more than 30 metabolites. A majority of these metabolites are products of glucuronidation. Approximately 65% is excreted in feces and 25% in the urine, while the remaining 10% is excreted not in feces or urine. [1] The terminal half-life is approximately 25-36 hours. [2]
CBD is hydroxylated by P450 liver enzymes into 7-OH-CBD. Its metabolites are products of primarily CYP2C19 and CYP3A4 activity, with potential activity of CYP1A1, CYP1A2, CYP2C9, and CYP2D6. [3] Similar to delta-9-THC, a majority of CBD is excreted in feces and some in the urine. [1] The terminal half-life is approximately 18-32 hours. [4]
This is a user sandbox of
Drhyoo. You can use it for testing or practicing edits. This is not the sandbox where you should draft your assigned article for a dashboard.wikiedu.org course. To find the right sandbox for your assignment, visit your Dashboard course page and follow the Sandbox Draft link for your assigned article in the My Articles section. |
{{
cite journal}}
: CS1 maint: multiple names: authors list (
link)