So far as I know, we never had RDA values set for omega-3 and omega-6 fatty acids, but now that we've switched to the Dietary Reference Intake they've added softer recommendations for the nonessentials. This pdf (linked to by the USDA here) lists the Adequate Intake for lenoleic (omega-6) fatty acids in the 14-17 g/day range for adult men, 11-12 g/day for adult women, while for alpha-linolenic (omega-3) the numbers are 1.6 g/day for adult men, 1.1 g/day for adult women.
The essential fatty acids were described by Burr and Burr in 1930 as those fatty acids which cured the deficiency disease brought on by a lack of fat in the diet. Arachidonic acid was one of the fatty acids which they tested and found to be effective. Further work has shown that any of the common ω-3 or-6 fatty acids will work. And the common usage in the field is that the term essential fatty acid comprises all the ω-3 or-6 fatty acids (or at least the polyunsaturated, straight-chain methylene-interrupted ones; there are some conjugated oddities like calendic acid that aren't.) Authorative sources include the whole families, without qualification. [1] [2] [3] The human body can make some long-chain PUFA (arachidonic acid, EPA and DHA) from lineolate or lineolinate. Some writers therefore hold that the LC-PUFA are not essential. But is not how the field has generally used the term.
EPA but not other LC ω-3 or -6 decrease natural killer cells in folks 55+. [4]
Obtusilic acid, 14:1 ω-3, is a monounsaturated ω-3 oil found in the seed oil of Lindera obtusiloba. [6]
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link)Eicosanoid signaling paths are complex. It is therefor difficult to characterize the action any particular eicosanoid. For example, PGE2 binds four receptors, dubbed EP1–4. Each is coded by a separate gene, and some exist in multiple isoforms. Each EP receptor in turn couple to a G protein. EP2, EP4 and one isoform of the EP3 receptors couple to Gs. This increases intracellular cAMP and is anti-inflammatory. EP1 and other EP3 isoforms couple to Gq. This leads to increased intracellular calcium and is pro-inflammatory. Finally, yet another EP3 isoform couples to Gi, which both decreases cAMP and increases calcium. Many immune-system cells express multiple receptors that couple these apparently opposing pathways. Presumably, EPA-derived PGE3 has a somewhat different effect of on this system, but it is not well-characterized.
Fish oil feedings make small effect on humans with low eicosanoid output, but make marked effect on the TX in urine in those with chronic inflammation. [7]
Interesterification can be used to add EPA to vegetable oils. [8]
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: CS1 maint: multiple names: authors list (
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: CS1 maint: multiple names: authors list (
link)
{{
cite web}}
: Check date values in: |date=
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help)
{{
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: CS1 maint: multiple names: authors list (
link)
So far as I know, we never had RDA values set for omega-3 and omega-6 fatty acids, but now that we've switched to the Dietary Reference Intake they've added softer recommendations for the nonessentials. This pdf (linked to by the USDA here) lists the Adequate Intake for lenoleic (omega-6) fatty acids in the 14-17 g/day range for adult men, 11-12 g/day for adult women, while for alpha-linolenic (omega-3) the numbers are 1.6 g/day for adult men, 1.1 g/day for adult women.
The essential fatty acids were described by Burr and Burr in 1930 as those fatty acids which cured the deficiency disease brought on by a lack of fat in the diet. Arachidonic acid was one of the fatty acids which they tested and found to be effective. Further work has shown that any of the common ω-3 or-6 fatty acids will work. And the common usage in the field is that the term essential fatty acid comprises all the ω-3 or-6 fatty acids (or at least the polyunsaturated, straight-chain methylene-interrupted ones; there are some conjugated oddities like calendic acid that aren't.) Authorative sources include the whole families, without qualification. [1] [2] [3] The human body can make some long-chain PUFA (arachidonic acid, EPA and DHA) from lineolate or lineolinate. Some writers therefore hold that the LC-PUFA are not essential. But is not how the field has generally used the term.
EPA but not other LC ω-3 or -6 decrease natural killer cells in folks 55+. [4]
Obtusilic acid, 14:1 ω-3, is a monounsaturated ω-3 oil found in the seed oil of Lindera obtusiloba. [6]
{{
cite journal}}
: CS1 maint: multiple names: authors list (
link){{
cite journal}}
: CS1 maint: multiple names: authors list (
link)Eicosanoid signaling paths are complex. It is therefor difficult to characterize the action any particular eicosanoid. For example, PGE2 binds four receptors, dubbed EP1–4. Each is coded by a separate gene, and some exist in multiple isoforms. Each EP receptor in turn couple to a G protein. EP2, EP4 and one isoform of the EP3 receptors couple to Gs. This increases intracellular cAMP and is anti-inflammatory. EP1 and other EP3 isoforms couple to Gq. This leads to increased intracellular calcium and is pro-inflammatory. Finally, yet another EP3 isoform couples to Gi, which both decreases cAMP and increases calcium. Many immune-system cells express multiple receptors that couple these apparently opposing pathways. Presumably, EPA-derived PGE3 has a somewhat different effect of on this system, but it is not well-characterized.
Fish oil feedings make small effect on humans with low eicosanoid output, but make marked effect on the TX in urine in those with chronic inflammation. [7]
Interesterification can be used to add EPA to vegetable oils. [8]
{{
cite web}}
: Check date values in: |year=
(
help)CS1 maint: multiple names: authors list (
link)
{{
cite journal}}
: CS1 maint: multiple names: authors list (
link)
{{
cite journal}}
: CS1 maint: multiple names: authors list (
link)
{{
cite journal}}
: CS1 maint: multiple names: authors list (
link)
{{
cite journal}}
: CS1 maint: multiple names: authors list (
link)
{{
cite web}}
: Check date values in: |date=
(
help)
{{
cite journal}}
: CS1 maint: multiple names: authors list (
link)