In molecular biology, framework regions are a subdivision of the fragment antigen binding region (Fab) of the antibody. Located on the tips of the Y-shaped molecule, the framework regions are responsible for supporting the binding of the hypervariable region (CDR) of the Fab to the antigen. [1] The side chains of certain amino acids in the framework help facilitate the stable binding of the antibody to the antigen [2] and define the position of the CDR so they are exposed on the surface of the chain ready to bind to an antigen. [3]
The framework region is made up of 4 amino acid segments between the 3 CDR regions of the Fab. The framework region makes up about 85% of the variable region. [3] To increase its stability, the framework region has less variability in its amino acid sequences compared to the CDR. There are 4 framework regions found on each antibody located on the two variable heavy domains and the two variable light domain.
In molecular biology, framework regions are a subdivision of the fragment antigen binding region (Fab) of the antibody. Located on the tips of the Y-shaped molecule, the framework regions are responsible for supporting the binding of the hypervariable region (CDR) of the Fab to the antigen. [1] The side chains of certain amino acids in the framework help facilitate the stable binding of the antibody to the antigen [2] and define the position of the CDR so they are exposed on the surface of the chain ready to bind to an antigen. [3]
The framework region is made up of 4 amino acid segments between the 3 CDR regions of the Fab. The framework region makes up about 85% of the variable region. [3] To increase its stability, the framework region has less variability in its amino acid sequences compared to the CDR. There are 4 framework regions found on each antibody located on the two variable heavy domains and the two variable light domain.