Change 1 (Introduction of section)
Replace “Genetic predisposition plays a role.[25]” with, “Endometriosis is a heritable condition that is influenced by both genetic and environmental factors. [1]”
Change 2 (Gene loci)
Replace bullet list and add the introduction sentence to the table and the table below: “The following table formulated from sources [1-3] identifies the most common loci and their associated details.”
| Chromosome | Gene/Region of Mutation | Gene Product | Function |
|---|---|---|---|
| 1 | WNT4 | Wingless-type MMTV integration site family member 4 | Vital for development of the female reproductive organs |
| 2 | GREB1/FN1 | Growth regulation by estrogen in breast cancer 1/Fibronectin 1 | Early response gene in the estrogen regulation pathway/Cell adhesion and migration processes |
| 7 | ID4 | Inhibitor of DNA binding 4 | Ovarian oncogene, biological function unknown |
| 6 | 7p15.2 | Transcription factors | Influence transcriptional regulation of uterine development |
| 9 | CDKN2BAS | Cyclin-dependent kinase inhibitor 2B antisense RNA | Regulation of tumour suppressor genes |
| 10 | 10q26 | ||
| 12 | VEZT | Vezatin, an adherens junction transmembrane protein | Tumor suppressor gene |
| 19 | MUC16 (CA-125) | Mucin 16, cell surface associated | Form protective mucous barriers |
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132588/ [2] https://www.ncbi.nlm.nih.gov/gene/94025 [3] https://www.ncbi.nlm.nih.gov/gene/2335
Thanks for sharing your proposed changes. Do you need formatting your table and adding citations? This is easier in the source based editing mode. Please let me know if I can help. Tables can take a bit longer to figure out! JenOttawa ( talk) 17:30, 6 November 2018 (UTC)
Change 1 (Introduction of section)
Replace “Genetic predisposition plays a role.[25]” with, “Endometriosis is a heritable condition that is influenced by both genetic and environmental factors. [1]”
Change 2 (Gene loci)
Replace bullet list and add the introduction sentence to the table and the table below: “The following table formulated from sources [1-3] identifies the most common loci and their associated details.”
| Chromosome | Gene/Region of Mutation | Gene Product | Function |
|---|---|---|---|
| 1 | WNT4 | Wingless-type MMTV integration site family member 4 | Vital for development of the female reproductive organs |
| 2 | GREB1/FN1 | Growth regulation by estrogen in breast cancer 1/Fibronectin 1 | Early response gene in the estrogen regulation pathway/Cell adhesion and migration processes |
| 7 | ID4 | Inhibitor of DNA binding 4 | Ovarian oncogene, biological function unknown |
| 6 | 7p15.2 | Transcription factors | Influence transcriptional regulation of uterine development |
| 9 | CDKN2BAS | Cyclin-dependent kinase inhibitor 2B antisense RNA | Regulation of tumour suppressor genes |
| 10 | 10q26 | ||
| 12 | VEZT | Vezatin, an adherens junction transmembrane protein | Tumor suppressor gene |
| 19 | MUC16 (CA-125) | Mucin 16, cell surface associated | Form protective mucous barriers |
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132588/ [2] https://www.ncbi.nlm.nih.gov/gene/94025 [3] https://www.ncbi.nlm.nih.gov/gene/2335
Thanks for sharing your proposed changes. Do you need formatting your table and adding citations? This is easier in the source based editing mode. Please let me know if I can help. Tables can take a bit longer to figure out! JenOttawa ( talk) 17:30, 6 November 2018 (UTC)