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Uche is a Nigerian name originating among the Igbo people, which can mean "intention", "will", "mind", or "sense". Variants can include Uchechukwu or Uchenna (which means "God's will" or "God's intention"), Ucheoma (which means "beautiful mind"), and Uchendu (which means "thinking/thought of life"). The name Uche may refer to:

• Uche Henry Agbo (born 1995), Nigerian football player
• Uche Akubuike (born 1980), Nigerian football player
• Uche Azikiwe (born 1947), Nigerian writer and first lady
• Uché Blackstock (born 1977/1978), American doctor
• Uche Chukwumerije (1939–2015), Nigerian politician
• Uche Eze (born 1983), Nigerian writer and entrepreneur
• Uche Iheruome (born 1987), Nigerian football player
• Uche Ikpeazu (born 1995), British football player
• Uche Jombo (born 1979), Nigerian actress
• Uche Kalu (born 1986), Nigerian football player
• Uche Nduka (born 1963), Nigerian writer
• Uche Nwaneri (1984-2022), American football player
• Uche Nwofor (born 1991), Nigerian football player
• Uche Oduoza (born 1986), British rugby player
• Uche Okafor (1967–2011), Nigerian football player
• Uche Okechukwu (born 1967), Nigerian football player
• Uche Okeke (born 1933), Nigerian artist
• Uche Sherif (born 1983), Nigerian football player
• Uche Secondus (born 1955), Nigerian politician

• Henry Uche (born 1990), Nigerian footballer
• Ikechukwu Uche (born 1984), Nigerian football player
• Isaac Uche (born 1981), Nigerian sprinter
• Josh Uche (born 1998), American football player
• Kalu Uche (born 1982), Nigerian football player
• Oguchi Uche (born 1987), Nigerian football player