From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Ubiquitin carboxyl-terminal hydrolase 8 is an
enzyme that in humans is encoded by the USP8
gene .
[5]
[6]
[7]
Interactions
USP8 has been shown to
interact with
RNF41
[8] and
STAM2 .
[9]
[10]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000138592 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000027363 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Puente XS, Sánchez LM, Overall CM, López-Otín C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nature Reviews. Genetics . 4 (7): 544–58.
doi :
10.1038/nrg1111 .
PMID
12838346 .
S2CID
2856065 .
^ Janssen JW, Schleithoff L, Bartram CR, Schulz AS (April 1998).
"An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme" . Oncogene . 16 (13): 1767–72.
doi :
10.1038/sj.onc.1201695 .
PMID
9582025 .
^
"Entrez Gene: USP8 ubiquitin specific peptidase 8" .
^ Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004).
"Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8" . Molecular and Cellular Biology . 24 (17): 7748–57.
doi :
10.1128/MCB.24.17.7748-7757.2004 .
PMC
506982 .
PMID
15314180 .
^ Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N (November 2003).
"Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain" . The Journal of Biological Chemistry . 278 (48): 48162–8.
doi :
10.1074/jbc.M306677200 .
PMID
13129930 .
^ Kato M, Miyazawa K, Kitamura N (December 2000).
"A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP" . The Journal of Biological Chemistry . 275 (48): 37481–7.
doi :
10.1074/jbc.M007251200 .
PMID
10982817 .
Further reading
D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Critical Reviews in Biochemistry and Molecular Biology . 33 (5): 337–52.
doi :
10.1080/10409239891204251 .
PMID
9827704 .
Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, et al. (1995).
"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Research . 1 (5): 223–9.
doi :
10.1093/dnares/1.5.223 .
PMID
7584044 .
Naviglio S, Mattecucci C, Matoskova B, Nagase T, Nomura N, Di Fiore PP, Draetta GF (June 1998).
"UBPY: a growth-regulated human ubiquitin isopeptidase" . The EMBO Journal . 17 (12): 3241–50.
doi :
10.1093/emboj/17.12.3241 .
PMC
1170662 .
PMID
9628861 .
Kato M, Miyazawa K, Kitamura N (December 2000).
"A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP" . The Journal of Biological Chemistry . 275 (48): 37481–7.
doi :
10.1074/jbc.M007251200 .
PMID
10982817 .
Gnesutta N, Ceriani M, Innocenti M, Mauri I, Zippel R, Sturani E, et al. (October 2001).
"Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1" . The Journal of Biological Chemistry . 276 (42): 39448–54.
doi :
10.1074/jbc.M103454200 .
hdl :
2434/28853 .
PMID
11500497 .
Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N (November 2003).
"Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain" . The Journal of Biological Chemistry . 278 (48): 48162–8.
doi :
10.1074/jbc.M306677200 .
PMID
13129930 .
Soares L, Seroogy C, Skrenta H, Anandasabapathy N, Lovelace P, Chung CD, et al. (January 2004). "Two isoforms of otubain 1 regulate T cell anergy via GRAIL". Nature Immunology . 5 (1): 45–54.
doi :
10.1038/ni1017 .
PMID
14661020 .
S2CID
27005972 .
Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004).
"Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8" . Molecular and Cellular Biology . 24 (17): 7748–57.
doi :
10.1128/MCB.24.17.7748-7757.2004 .
PMC
506982 .
PMID
15314180 .
Berruti G, Martegani E (January 2005).
"The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells" . Biology of Reproduction . 72 (1): 14–21.
doi :
10.1095/biolreprod.104.030866 .
PMID
15342353 .
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005).
"Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer" . Molecular & Cellular Proteomics . 4 (6): 785–95.
doi :
10.1074/mcp.M500021-MCP200 .
PMID
15778465 .
Row PE, Prior IA, McCullough J, Clague MJ, Urbé S (May 2006).
"The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation" . The Journal of Biological Chemistry . 281 (18): 12618–24.
doi :
10.1074/jbc.M512615200 .
PMID
16520378 .
Mizuno E, Kobayashi K, Yamamoto A, Kitamura N, Komada M (August 2006).
"A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes" . Traffic . 7 (8): 1017–31.
doi :
10.1111/j.1600-0854.2006.00452.x .
PMID
16771824 .
Avvakumov GV, Walker JR, Xue S, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S (December 2006).
"Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8)" . The Journal of Biological Chemistry . 281 (49): 38061–70.
doi :
10.1074/jbc.M606704200 .
PMID
17035239 .
PDB gallery
1whb : Solution structure of the Rhodanese-like domain in human ubiquitin specific protease 8 (UBP8)
2a9u : Structure of the N-terminal domain of Human Ubiquitin carboxyl-terminal hydrolase 8 (USP8)
2gfo : Structure of the Catalytic Domain of Human Ubiquitin Carboxyl-terminal Hydrolase 8
2gwf : Structure of a USP8-NRDP1 complex