Ubiquitin carboxyl-terminal hydrolase 2 is an
enzyme that in humans is encoded by the USP2gene.[5][6]
Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the
polyubiquitin chains. The disassembly process is mediated by
ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478).[supplied by OMIM][6]
D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52.
doi:
10.1080/10409239891204251.
PMID9827704.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105.
doi:
10.1038/ncb1086.
PMID14743216.
S2CID11683986.
Ubiquitin carboxyl-terminal hydrolase 2 is an
enzyme that in humans is encoded by the USP2gene.[5][6]
Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the
polyubiquitin chains. The disassembly process is mediated by
ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478).[supplied by OMIM][6]
D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52.
doi:
10.1080/10409239891204251.
PMID9827704.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105.
doi:
10.1038/ncb1086.
PMID14743216.
S2CID11683986.