Ubiquitin carboxyl-terminal hydrolase 15 is an
enzyme that in humans is encoded by the USP15gene.[4][5]
Ubiquitin is a highly conserved protein involved in the regulation of intracellular
protein breakdown,
cell cycle regulation, and stress response, which is released from degraded proteins by disassembly of the
polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs).[5]
D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52.
doi:
10.1080/10409239891204251.
PMID9827704.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92.
doi:
10.1038/nbt1240.
PMID16964243.
S2CID14294292.
Baker RT, Wang XW, Woollatt E, et al. (1999). "Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases". Genomics. 59 (3): 264–74.
doi:
10.1006/geno.1999.5879.
PMID10444327.
Ubiquitin carboxyl-terminal hydrolase 15 is an
enzyme that in humans is encoded by the USP15gene.[4][5]
Ubiquitin is a highly conserved protein involved in the regulation of intracellular
protein breakdown,
cell cycle regulation, and stress response, which is released from degraded proteins by disassembly of the
polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs).[5]
D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52.
doi:
10.1080/10409239891204251.
PMID9827704.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92.
doi:
10.1038/nbt1240.
PMID16964243.
S2CID14294292.
Baker RT, Wang XW, Woollatt E, et al. (1999). "Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases". Genomics. 59 (3): 264–74.
doi:
10.1006/geno.1999.5879.
PMID10444327.