Netrin receptor UNC5C is a
protein that in humans is encoded by the UNC5Cgene.[5][6][7]
This gene product belongs to the UNC-5 family of
netrin receptors. Netrins are secreted proteins that direct axon extension and
cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are
transmembrane proteins containing 2
immunoglobulin (Ig)-like domains and 2 type I
thrombospondin motifs in the extracellular region.[7]
^Ackerman SL, Knowles BB (Dec 1998). "Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23". Genomics. 52 (2): 205–8.
doi:
10.1006/geno.1998.5425.
PMID9782087.
Netrin receptor UNC5C is a
protein that in humans is encoded by the UNC5Cgene.[5][6][7]
This gene product belongs to the UNC-5 family of
netrin receptors. Netrins are secreted proteins that direct axon extension and
cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are
transmembrane proteins containing 2
immunoglobulin (Ig)-like domains and 2 type I
thrombospondin motifs in the extracellular region.[7]
^Ackerman SL, Knowles BB (Dec 1998). "Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23". Genomics. 52 (2): 205–8.
doi:
10.1006/geno.1998.5425.
PMID9782087.