The UGT1A locus includes thirteen unique alternate first
exons followed by four common exons. Four of the alternate first exons are considered
pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate
binding site, and is regulated by its own
promoter.[2]
References
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Gong QH, Cho JW, Huang T, et al. (2001). "Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus". Pharmacogenetics. 11 (4): 357–68.
doi:
10.1097/00008571-200106000-00011.
PMID11434514.
Peters WH, te Morsche RH, Roelofs HM (2003). "Combined polymorphisms in UDP-glucuronosyltransferases 1A1 and 1A6: implications for patients with Gilbert's syndrome". J. Hepatol. 38 (1): 3–8.
doi:
10.1016/S0168-8278(02)00306-9.
PMID12480553.
Giuliani L, Ciotti M, Stoppacciaro A, et al. (2005). "UDP-glucuronosyltransferases 1A expression in human urinary bladder and colon cancer by immunohistochemistry". Oncol. Rep. 13 (2): 185–91.
doi:
10.3892/or.13.2.185 (inactive 31 January 2024).
PMID15643497.{{
cite journal}}: CS1 maint: DOI inactive as of January 2024 (
link)
Mercke Odeberg J, Andrade J, Holmberg K, et al. (2007). "UGT1A polymorphisms in a Swedish cohort and a human diversity panel, and the relation to bilirubin plasma levels in males and females". Eur. J. Clin. Pharmacol. 62 (10): 829–37.
doi:
10.1007/s00228-006-0166-3.
PMID16909274.
S2CID30425233.
The UGT1A locus includes thirteen unique alternate first
exons followed by four common exons. Four of the alternate first exons are considered
pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate
binding site, and is regulated by its own
promoter.[2]
References
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Gong QH, Cho JW, Huang T, et al. (2001). "Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus". Pharmacogenetics. 11 (4): 357–68.
doi:
10.1097/00008571-200106000-00011.
PMID11434514.
Peters WH, te Morsche RH, Roelofs HM (2003). "Combined polymorphisms in UDP-glucuronosyltransferases 1A1 and 1A6: implications for patients with Gilbert's syndrome". J. Hepatol. 38 (1): 3–8.
doi:
10.1016/S0168-8278(02)00306-9.
PMID12480553.
Giuliani L, Ciotti M, Stoppacciaro A, et al. (2005). "UDP-glucuronosyltransferases 1A expression in human urinary bladder and colon cancer by immunohistochemistry". Oncol. Rep. 13 (2): 185–91.
doi:
10.3892/or.13.2.185 (inactive 31 January 2024).
PMID15643497.{{
cite journal}}: CS1 maint: DOI inactive as of January 2024 (
link)
Mercke Odeberg J, Andrade J, Holmberg K, et al. (2007). "UGT1A polymorphisms in a Swedish cohort and a human diversity panel, and the relation to bilirubin plasma levels in males and females". Eur. J. Clin. Pharmacol. 62 (10): 829–37.
doi:
10.1007/s00228-006-0166-3.
PMID16909274.
S2CID30425233.