Ubiquilin-1 was first identified through its interactions with
presenilins.[11] Two transcript variants encoding different isoforms have been found for this gene.[7]
Related proteins
Human UBQLN1 shares a high degree of similarity with related ubiquilins including
UBQLN2 and
UBQLN4.[12]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ozaki T, Hishiki T, Toyama Y, Yuasa S, Nakagawara A, Sakiyama S (August 1997). "Identification of a new cellular protein that can interact specifically with DAN". DNA and Cell Biology. 16 (8): 985–91.
doi:
10.1089/dna.1997.16.985.
PMID9303440.
^Haapasalo A, Viswanathan J, Bertram L, Soininen H, Tanzi RE, Hiltunen M (February 2010). "Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation". Biochemical Society Transactions. 38 (Pt 1): 150–5.
doi:
10.1042/BST0380150.
hdl:11858/00-001M-0000-0010-7C06-4.
PMID20074050.
^Kim TY, Kim E, Yoon SK, Yoon JB (May 2008). "Herp enhances ER-associated protein degradation by recruiting ubiquilins". Biochemical and Biophysical Research Communications. 369 (2): 741–6.
doi:
10.1016/j.bbrc.2008.02.086.
PMID18307982.
Ozaki T, Kondo K, Nakamura Y, Ichimiya S, Nakagawara A, Sakiyama S (August 1997). "Interaction of DA41, a DAN-binding protein, with the epidermal growth factor-like protein, S(1-5)". Biochemical and Biophysical Research Communications. 237 (2): 245–50.
doi:
10.1006/bbrc.1997.7122.
PMID9268694.
Ozaki T, Hanaoka E, Naka M, Nakagawara A, Sakiyama S (June 1999). "Cloning and characterization of rat BAT3 cDNA". DNA and Cell Biology. 18 (6): 503–12.
doi:
10.1089/104454999315222.
PMID10390159.
Bedford FK, Kittler JT, Muller E, Thomas P, Uren JM, Merlo D, et al. (September 2001). "GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1". Nature Neuroscience. 4 (9): 908–16.
doi:
10.1038/nn0901-908.
PMID11528422.
S2CID13078743.
Persson P, Stockhausen MT, Påhlman S, Axelson H (November 2004). "Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells". International Journal of Oncology. 25 (5): 1213–21.
doi:
10.3892/ijo.25.5.1213.
PMID15492808.
Ubiquilin-1 was first identified through its interactions with
presenilins.[11] Two transcript variants encoding different isoforms have been found for this gene.[7]
Related proteins
Human UBQLN1 shares a high degree of similarity with related ubiquilins including
UBQLN2 and
UBQLN4.[12]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ozaki T, Hishiki T, Toyama Y, Yuasa S, Nakagawara A, Sakiyama S (August 1997). "Identification of a new cellular protein that can interact specifically with DAN". DNA and Cell Biology. 16 (8): 985–91.
doi:
10.1089/dna.1997.16.985.
PMID9303440.
^Haapasalo A, Viswanathan J, Bertram L, Soininen H, Tanzi RE, Hiltunen M (February 2010). "Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation". Biochemical Society Transactions. 38 (Pt 1): 150–5.
doi:
10.1042/BST0380150.
hdl:11858/00-001M-0000-0010-7C06-4.
PMID20074050.
^Kim TY, Kim E, Yoon SK, Yoon JB (May 2008). "Herp enhances ER-associated protein degradation by recruiting ubiquilins". Biochemical and Biophysical Research Communications. 369 (2): 741–6.
doi:
10.1016/j.bbrc.2008.02.086.
PMID18307982.
Ozaki T, Kondo K, Nakamura Y, Ichimiya S, Nakagawara A, Sakiyama S (August 1997). "Interaction of DA41, a DAN-binding protein, with the epidermal growth factor-like protein, S(1-5)". Biochemical and Biophysical Research Communications. 237 (2): 245–50.
doi:
10.1006/bbrc.1997.7122.
PMID9268694.
Ozaki T, Hanaoka E, Naka M, Nakagawara A, Sakiyama S (June 1999). "Cloning and characterization of rat BAT3 cDNA". DNA and Cell Biology. 18 (6): 503–12.
doi:
10.1089/104454999315222.
PMID10390159.
Bedford FK, Kittler JT, Muller E, Thomas P, Uren JM, Merlo D, et al. (September 2001). "GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1". Nature Neuroscience. 4 (9): 908–16.
doi:
10.1038/nn0901-908.
PMID11528422.
S2CID13078743.
Persson P, Stockhausen MT, Påhlman S, Axelson H (November 2004). "Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells". International Journal of Oncology. 25 (5): 1213–21.
doi:
10.3892/ijo.25.5.1213.
PMID15492808.