This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the
neuroblastoma tumor suppressor genes.[7]
Ohira M, Kageyama H, Mihara M, et al. (2000). "Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line". Oncogene. 19 (37): 4302–7.
doi:
10.1038/sj.onc.1203786.
PMID10980605.
S2CID24163907.
Kaneko C, Hatakeyama S, Matsumoto M, et al. (2003). "Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a". Biochem. Biophys. Res. Commun. 300 (2): 297–304.
doi:
10.1016/S0006-291X(02)02834-6.
PMID12504083.
Krona C, Ejeskär K, Abel F, et al. (2003). "Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2". Oncogene. 22 (15): 2343–51.
doi:
10.1038/sj.onc.1206324.
PMID12700669.
S2CID7749013.
This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the
neuroblastoma tumor suppressor genes.[7]
Ohira M, Kageyama H, Mihara M, et al. (2000). "Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line". Oncogene. 19 (37): 4302–7.
doi:
10.1038/sj.onc.1203786.
PMID10980605.
S2CID24163907.
Kaneko C, Hatakeyama S, Matsumoto M, et al. (2003). "Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a". Biochem. Biophys. Res. Commun. 300 (2): 297–304.
doi:
10.1016/S0006-291X(02)02834-6.
PMID12504083.
Krona C, Ejeskär K, Abel F, et al. (2003). "Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2". Oncogene. 22 (15): 2343–51.
doi:
10.1038/sj.onc.1206324.
PMID12700669.
S2CID7749013.