NEDD8-activating enzyme E1 catalytic subunit is a
protein that in humans is encoded by the UBA3gene.[5][6]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a
ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]
This enzyme contains an E2 binding
domain, which resembles
ubiquitin, and recruits the
catalytic core of the E2 enzyme
UBE2M (Ubc12) in a similar manner to that in which ubiquitin
interacts with ubiquitin binding
domains.[7]
Norman JA, Shiekhattar R (2006). "Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications". Biochemistry. 45 (9): 3014–9.
doi:
10.1021/bi052435a.
PMID16503656.
NEDD8-activating enzyme E1 catalytic subunit is a
protein that in humans is encoded by the UBA3gene.[5][6]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a
ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]
This enzyme contains an E2 binding
domain, which resembles
ubiquitin, and recruits the
catalytic core of the E2 enzyme
UBE2M (Ubc12) in a similar manner to that in which ubiquitin
interacts with ubiquitin binding
domains.[7]
Norman JA, Shiekhattar R (2006). "Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications". Biochemistry. 45 (9): 3014–9.
doi:
10.1021/bi052435a.
PMID16503656.