From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
UDP-N-acetylhexosamine pyrophosphorylase is an
enzyme that in humans is encoded by the UAP1
gene.
[5]
[6]
[7]
- ^
a
b
c
GRCh38: Ensembl release 89: ENSG00000117143 –
Ensembl, May 2017
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a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000026670 –
Ensembl, May 2017
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^
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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^
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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^ Mio T, Yabe T, Arisawa M, Yamada-Okabe H (Jul 1998).
"The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism". J Biol Chem. 273 (23): 14392–7.
doi:
10.1074/jbc.273.23.14392.
PMID
9603950.
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^ Diekman AB, Goldberg E (Aug 1994).
"Characterization of a human antigen with sera from infertile patients". Biol Reprod. 50 (5): 1087–93.
doi:
10.1095/biolreprod50.5.1087.
PMID
8025165.
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^
"Entrez Gene: UAP1 UDP-N-acteylglucosamine pyrophosphorylase 1".
- Diekman AB, Olson G, Goldberg E (1998). "Expression of the human antigen SPAG2 in the testis and localization to the outer dense fibers in spermatozoa". Mol. Reprod. Dev. 50 (3): 284–93.
doi:
10.1002/(SICI)1098-2795(199807)50:3<284::AID-MRD4>3.0.CO;2-F.
PMID
9621304.
S2CID
25271682.
- Wang-Gillam A, Pastuszak I, Elbein AD (1998).
"A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc". J. Biol. Chem. 273 (42): 27055–7.
doi:
10.1074/jbc.273.42.27055.
PMID
9765219.
- Peneff C, Ferrari P, Charrier V, et al. (2002).
"Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture". EMBO J. 20 (22): 6191–202.
doi:
10.1093/emboj/20.22.6191.
PMC
125729.
PMID
11707391.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
Bibcode:
2002PNAS...9916899M.
doi:
10.1073/pnas.242603899.
PMC
139241.
PMID
12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.
doi:
10.1101/gr.2596504.
PMC
528928.
PMID
15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8.
Bibcode:
2005Natur.437.1173R.
doi:
10.1038/nature04209.
PMID
16189514.
S2CID
4427026.
- Gregory SG, Barlow KF, McLay KE, et al. (2006).
"The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21.
Bibcode:
2006Natur.441..315G.
doi:
10.1038/nature04727.
PMID
16710414.
PDB gallery |
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1jv1: CRYSTAL STRUCTURE OF HUMAN AGX1 COMPLEXED WITH UDPGLCNAC
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1jv3: CRYSTAL STRUCTURE OF HUMAN AGX1 COMPLEXED WITH UDPGALNAC
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1jvd: CRYSTAL STRUCTURE OF HUMAN AGX2 COMPLEXED WITH UDPGLCNAC
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1jvg: CRYSTAL STRUCTURE OF HUMAN AGX2 COMPLEXED WITH UDPGALNAC
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1vm8: Crystal structure of UDP-N-acetylglucosamine pyrophosphorylase (Agx2) from Mus musculus at 2.50 A resolution
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