Tuberous sclerosis complex (TSC) tumor suppressors form the TSC1- TSC2 molecular complex. Under poor growth conditions the TSC1-TSC2 complex limits cell growth. [1] A key promoter of cell growth, mTORC1, is inhibited by the tuberous sclerosis complex. [1] Insulin activates mTORC1 and causes dissociation of TSC from the surface of lysosomes. [2]
Resistance to ischemia- reperfusion injury by protein restriction is mediated by activation of the tuberous sclerosis complex. [3]
Tuberous sclerosis complex (TSC) tumor suppressors form the TSC1- TSC2 molecular complex. Under poor growth conditions the TSC1-TSC2 complex limits cell growth. [1] A key promoter of cell growth, mTORC1, is inhibited by the tuberous sclerosis complex. [1] Insulin activates mTORC1 and causes dissociation of TSC from the surface of lysosomes. [2]
Resistance to ischemia- reperfusion injury by protein restriction is mediated by activation of the tuberous sclerosis complex. [3]