TMEM151B | |||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | TMEM151B, C6orf137, TMEM193, bA444E17.5, transmembrane protein 151B | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 2685169 HomoloGene: 19365 GeneCards: TMEM151B | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
Transmembrane protein 151B is a protein that in humans is encoded by the TMEM151B gene. [5]
The Transmembrane protein 151B gene is also known as TMEM151B, C6orf137, and bA444E17.5. [6]
The gene is located on the positive strand of chromosome 6 at the location 6p21.1 from the chromosome position 44270450 to 44279444, for a total length of 8,995 base pairs. [7] It is a complex locus that contains both TMEM151B and SPATS1. [8] TMEM151B has one paralog: TMEM151A. [9]
The mRNA contains 3 exons, with a transcribed mRNA length of 4911bp, and the coding region containing 1701bp. [7]
The protein has a length of 566 amino acids and contains two transmembrane domains. [6] According to Compute pI/Mw, molecular weight of approximately 61 kDa, which matches the weight listed on NCBI, and a theoretical isoelectric point of 6.72. [11] [6] The human TMEM151B protein composition is poor in lysine and arginine, lysine comprising 1.4% of the amino acids and arginine making up 0.8% of the total protein. The mouse ortholog is also arginine poor. [12]
RNA-seq gene expression profiling shows high expression in the brain, and notable expression in the testes. [14] NCBI geo profiles similarly show localization to the brain tissues. [15] Within the mouse brain, TMEM151B has high expression particularly within the cerebellum, medulla, and olfactory bulb according to the Allen Brain Atlas. [13]
The TMEM151B protein interacts with one other protein according to BioGRID. [16]
The TMEM151B gene is conserved within most vertebrates, and appears to be conserved within some invertebrates. Its paralog, TMEM151A, has a 47.7% sequence identity with TMEM151B. [9] [18] The evolution rate is relatively slow: between the rate of change in fibrinogen alpha and cytochrome c. [9] [19]
Alternative splicing of TMEM151B along with 4 other genes were linked to colorectal cancer. [20] It was also found to be up-regulated in post-menopausal breast cancer. [21] [22] A SNP found within TMEM151B is associated with the development of lean muscle. [23]
TMEM151B | |||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | TMEM151B, C6orf137, TMEM193, bA444E17.5, transmembrane protein 151B | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 2685169 HomoloGene: 19365 GeneCards: TMEM151B | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
Transmembrane protein 151B is a protein that in humans is encoded by the TMEM151B gene. [5]
The Transmembrane protein 151B gene is also known as TMEM151B, C6orf137, and bA444E17.5. [6]
The gene is located on the positive strand of chromosome 6 at the location 6p21.1 from the chromosome position 44270450 to 44279444, for a total length of 8,995 base pairs. [7] It is a complex locus that contains both TMEM151B and SPATS1. [8] TMEM151B has one paralog: TMEM151A. [9]
The mRNA contains 3 exons, with a transcribed mRNA length of 4911bp, and the coding region containing 1701bp. [7]
The protein has a length of 566 amino acids and contains two transmembrane domains. [6] According to Compute pI/Mw, molecular weight of approximately 61 kDa, which matches the weight listed on NCBI, and a theoretical isoelectric point of 6.72. [11] [6] The human TMEM151B protein composition is poor in lysine and arginine, lysine comprising 1.4% of the amino acids and arginine making up 0.8% of the total protein. The mouse ortholog is also arginine poor. [12]
RNA-seq gene expression profiling shows high expression in the brain, and notable expression in the testes. [14] NCBI geo profiles similarly show localization to the brain tissues. [15] Within the mouse brain, TMEM151B has high expression particularly within the cerebellum, medulla, and olfactory bulb according to the Allen Brain Atlas. [13]
The TMEM151B protein interacts with one other protein according to BioGRID. [16]
The TMEM151B gene is conserved within most vertebrates, and appears to be conserved within some invertebrates. Its paralog, TMEM151A, has a 47.7% sequence identity with TMEM151B. [9] [18] The evolution rate is relatively slow: between the rate of change in fibrinogen alpha and cytochrome c. [9] [19]
Alternative splicing of TMEM151B along with 4 other genes were linked to colorectal cancer. [20] It was also found to be up-regulated in post-menopausal breast cancer. [21] [22] A SNP found within TMEM151B is associated with the development of lean muscle. [23]