Touton giant cells are a type of multinucleated giant cell seen in lesions with high lipid content such as fat necrosis, xanthoma, and xanthelasma and xanthogranulomas. They are also found in dermatofibroma. [1]
Touton giant cells are named for Karl Touton, a German botanist and dermatologist. [2] Karl Touton first observed these cells in 1885 and named them "xanthelasmatic giant cells", a name which has since fallen out of favor. [3]
Touton giant cells, being multinucleated giant cells, can be distinguished by the presence of several nuclei in a distinct pattern. They contain a ring of nuclei surrounding a central homogeneous cytoplasm, while foamy cytoplasm surrounds the nuclei. [4] [5] The cytoplasm surrounded by the nuclei has been described as both amphophilic and eosinophilic, while the cytoplasm near the periphery of the cell is pale and foamy in appearance. [6]
Touton giant cells are formed by the fusion of macrophage-derived foam cells. It has been suggested that cytokines such as interferon gamma, interleukin-3, and M-CSF may be involved in the production of Touton giant cells. [7] [8]
Touton giant cells are a type of multinucleated giant cell seen in lesions with high lipid content such as fat necrosis, xanthoma, and xanthelasma and xanthogranulomas. They are also found in dermatofibroma. [1]
Touton giant cells are named for Karl Touton, a German botanist and dermatologist. [2] Karl Touton first observed these cells in 1885 and named them "xanthelasmatic giant cells", a name which has since fallen out of favor. [3]
Touton giant cells, being multinucleated giant cells, can be distinguished by the presence of several nuclei in a distinct pattern. They contain a ring of nuclei surrounding a central homogeneous cytoplasm, while foamy cytoplasm surrounds the nuclei. [4] [5] The cytoplasm surrounded by the nuclei has been described as both amphophilic and eosinophilic, while the cytoplasm near the periphery of the cell is pale and foamy in appearance. [6]
Touton giant cells are formed by the fusion of macrophage-derived foam cells. It has been suggested that cytokines such as interferon gamma, interleukin-3, and M-CSF may be involved in the production of Touton giant cells. [7] [8]