Topsy may refer to:

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• Topsy, a character in the novel Uncle Tom's Cabin
• Topsy, a character in the 2018 film Mary Poppins Returns
• Topsy and Eva, a 1928 film based on Uncle Tom's Cabin
• Topsy and Tim, a children's book series
• Topsy (Tom and Jerry), a character in the cartoon series Tom and Jerry
• "Topsy" (instrumental), a jazz instrumental first recorded by Count Basie, then by Benny Goodman, and later by Cozy Cole
• "Topsy" (Bob's Burgers), the 38th episode of the animated comedy series Bob's Burgers

• Topsy Sinden (1878–1950), an English dancer, actress, and singer
• Topsy (d.1998), an abused Chinese girl, subject of The Story of Topsy, a book by Mildred Cable

• Topsy, Missouri, an unincorporated community
• Topsy, Oklahoma, a rural community also known as "Chloeta"

• Topsy (elephant) (c. 1875–1903), a circus animal electrocuted by her owners
• Topsy (analytics), an online social media and communications insights platform
• A codename of the Mitsubishi Ki-5-II, an aircraft
• Topsy's Roost, a former restaurant and nightclub at Playland-at-the-Beach in San Francisco

• Topsy-Turvy (disambiguation)

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