Toponomics is a discipline in systems biology, molecular cell biology, and histology concerning the study of the toponome of organisms. [1] [2] It is the field of study that purposes to decode the complete toponome in health and disease (the human toponome project) [3]—which is the next big challenge in human biotechnology after having decoded the human genome. [3] [4]
A toponome is the spatial network code of proteins and other biomolecules in morphologically intact cells and tissues. [2] [5]
The spatial organization of biomolecules in cells is directly revealed by imaging cycler microscopy with parameter- and dimension-unlimited functional resolution. The resulting toponome structures are hierarchically organized and can be described by a three symbol code. [1] [5] [6] [7]
The terms toponome and toponomics were introduced in 2003 by Walter Schubert based on observations with imaging cycler microscopes (ICM). [1]
Toponome derived from the ancient Greek nouns topos (τόπος, 'place, position') and 'nomos' (νόμος, 'law'). Hence toponomics is a descriptive term addressing the fact that the spatial network of biomolecules in cells follows topological rules enabling coordinated actions. [1]
{{
cite book}}
: |journal=
ignored (
help)
Toponomics is a discipline in systems biology, molecular cell biology, and histology concerning the study of the toponome of organisms. [1] [2] It is the field of study that purposes to decode the complete toponome in health and disease (the human toponome project) [3]—which is the next big challenge in human biotechnology after having decoded the human genome. [3] [4]
A toponome is the spatial network code of proteins and other biomolecules in morphologically intact cells and tissues. [2] [5]
The spatial organization of biomolecules in cells is directly revealed by imaging cycler microscopy with parameter- and dimension-unlimited functional resolution. The resulting toponome structures are hierarchically organized and can be described by a three symbol code. [1] [5] [6] [7]
The terms toponome and toponomics were introduced in 2003 by Walter Schubert based on observations with imaging cycler microscopes (ICM). [1]
Toponome derived from the ancient Greek nouns topos (τόπος, 'place, position') and 'nomos' (νόμος, 'law'). Hence toponomics is a descriptive term addressing the fact that the spatial network of biomolecules in cells follows topological rules enabling coordinated actions. [1]
{{
cite book}}
: |journal=
ignored (
help)