This gene encodes a
DNAtopoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme
catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the
supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of
genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.[7]
Kobayashi M, Hanai R (2001). "M phase-specific association of human topoisomerase IIIbeta with chromosomes". Biochem. Biophys. Res. Commun. 287 (1): 282–7.
doi:
10.1006/bbrc.2001.5580.
PMID11549288.
Cho YH, Park JY, Han SY, Chung IK (2004). "Identification of the functional elements in the promoter region of human DNA topoisomerase IIIbeta gene". Biochim. Biophys. Acta. 1679 (3): 272–8.
doi:
10.1016/j.bbaexp.2004.08.001.
PMID15358519.
This gene encodes a
DNAtopoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme
catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the
supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of
genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.[7]
Kobayashi M, Hanai R (2001). "M phase-specific association of human topoisomerase IIIbeta with chromosomes". Biochem. Biophys. Res. Commun. 287 (1): 282–7.
doi:
10.1006/bbrc.2001.5580.
PMID11549288.
Cho YH, Park JY, Han SY, Chung IK (2004). "Identification of the functional elements in the promoter region of human DNA topoisomerase IIIbeta gene". Biochim. Biophys. Acta. 1679 (3): 272–8.
doi:
10.1016/j.bbaexp.2004.08.001.
PMID15358519.