The Trail of the Lonesome Pine may refer to:

• The Trail of the Lonesome Pine (novel), 1908, by John Fox, Jr.
• Other works inspired by the novel:
  • The Trail of the Lonesome Pine, a 1912 stage adaptation by Eugene Walter
  • "The Trail of the Lonesome Pine" (song), 1913
    • Trail of the Lonesome Pine, a Laurel and Hardy compilation album containing the song of the same name
  • The Trail of the Lonesome Pine (1916 film)
  • The Trail of the Lonesome Pine (1923 film)
  • The Trail of the Lonesome Pine (1936 film)

This disambiguation page lists articles associated with the title The Trail of the Lonesome Pine.
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The Trail of the Lonesome Pine stage play is still performed annually in Big Stone Gap, Virginia, at the outdoor theater