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WikiProject icon Pharmacology Template‑class
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First graph's source: How were these E2 levels measured premenopause?

Since I can't access the Kuhnz 1993 PMID 8240460, I have to ask this template's contributor(s): If these are premenopausal women, how are they getting measured at T=0 as having zero endogenous estradiol? Why are they rising from zero as if the dosing was for a postmenopausal or orchiectomied female? -- The only way I could imagine this making sense is if the study were measuring radiolabeled E2 alone, but neither this graph's description nor the available Kuhnz abstract mention radiolabeling.

I suppose it could also be that the graph is supposed to represent increase in E2 above endogenous baseline, but the graph's description doesn't mention that either.

107.77.223.50 ( talk) 18:58, 26 November 2020 (UTC) Observer reply

From Wikipedia, the free encyclopedia
WikiProject icon Pharmacology Template‑class
WikiProject iconThis template is within the scope of WikiProject Pharmacology, a collaborative effort to improve the coverage of Pharmacology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.
TemplateThis template does not require a rating on Wikipedia's content assessment scale.
WikiProject icon Medicine Template‑class
WikiProject iconThis template is within the scope of WikiProject Medicine. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.
TemplateThis template does not require a rating on Wikipedia's content assessment scale.
WikiProject icon Women's Health Template‑class
WikiProject iconThis template is within the scope of WikiProject Women's Health, a collaborative effort to improve the coverage of Women's Health on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.
TemplateThis template does not require a rating on Wikipedia's content assessment scale.

First graph's source: How were these E2 levels measured premenopause?

Since I can't access the Kuhnz 1993 PMID 8240460, I have to ask this template's contributor(s): If these are premenopausal women, how are they getting measured at T=0 as having zero endogenous estradiol? Why are they rising from zero as if the dosing was for a postmenopausal or orchiectomied female? -- The only way I could imagine this making sense is if the study were measuring radiolabeled E2 alone, but neither this graph's description nor the available Kuhnz abstract mention radiolabeling.

I suppose it could also be that the graph is supposed to represent increase in E2 above endogenous baseline, but the graph's description doesn't mention that either.

107.77.223.50 ( talk) 18:58, 26 November 2020 (UTC) Observer reply


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