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Amphetamine pharmacodynamics template. |
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Hi, new to editing Wikipedia sorry for not logging in. There's a vesicle opening into the outside of the cell (synapse) at the bottom of the diagram. Should this vesicle be containing blue dots (amphetamine) as well?
If not, it would appear to show why extended release formulations and redosing in illicit consumers are associated with exponentially more neurotoxicity than subjects taking it once per day: the limited DAT and other transporters which still are working normally get clogged with amphetamine which has a higher affinity, leaving all the monoamines in the synapse trapped. — Preceding unsigned comment added by 108.56.194.48 ( talk) 14:29, 5 November 2018 (UTC)
Caveat
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This review states: In a nutshell, amphetamine apparently can promote vesicular fusion in rat DA neurons in vivo; however, the concentration of DA in synaptic vesicles that contain amphetamine and undergo exocytosis would necessarily be smaller than that of vesicles with no amphetamine molecules within them. So, even if amphetamine does promote vesicular fusion in human DA neurons, that's not really a notable mode of DA release due to low vesicular concentrations of DA. |
Seppi333 ( Insert 2¢) 22:05, 5 November 2018 (UTC)
In the table header, I assert: Pharmacodynamics of amphetamine enantiomers in a dopamine neuron. Enantiomers is superfluous since amphetamine is its enantiomers. Both may be assumed to have these properties since no distinction is made in the graphic or caption.
The graphic would be easier to understand if amphetamine were red like the trafficking paths. Same with the others. If using the same color makes the substance units somewhat indistinguishable the path, path thickness can be reduced or path color lightened.
Why is the vesicle wall (line) thickness different in the internal vesicle than the fused vesicle?
I wonder if "trace amine or amphetamine (in)" might graphically read better "trace amine (in) amphetamine (in)".
I muse over ways this schematic could keep the content but allow ordinary readers to grasp the basic mechanism without being daunted by the details. One consideration is altering the layout so the paths could be uncrossed as much as possible.
I'll leave it there for now. Box73 ( talk) 11:02, 18 November 2015 (UTC)
This is the
talk page for discussing improvements to the
Amphetamine pharmacodynamics template. |
|
This template does not require a rating on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||||||||||||||||||||||||
|
Hi, new to editing Wikipedia sorry for not logging in. There's a vesicle opening into the outside of the cell (synapse) at the bottom of the diagram. Should this vesicle be containing blue dots (amphetamine) as well?
If not, it would appear to show why extended release formulations and redosing in illicit consumers are associated with exponentially more neurotoxicity than subjects taking it once per day: the limited DAT and other transporters which still are working normally get clogged with amphetamine which has a higher affinity, leaving all the monoamines in the synapse trapped. — Preceding unsigned comment added by 108.56.194.48 ( talk) 14:29, 5 November 2018 (UTC)
Caveat
|
---|
This review states: In a nutshell, amphetamine apparently can promote vesicular fusion in rat DA neurons in vivo; however, the concentration of DA in synaptic vesicles that contain amphetamine and undergo exocytosis would necessarily be smaller than that of vesicles with no amphetamine molecules within them. So, even if amphetamine does promote vesicular fusion in human DA neurons, that's not really a notable mode of DA release due to low vesicular concentrations of DA. |
Seppi333 ( Insert 2¢) 22:05, 5 November 2018 (UTC)
In the table header, I assert: Pharmacodynamics of amphetamine enantiomers in a dopamine neuron. Enantiomers is superfluous since amphetamine is its enantiomers. Both may be assumed to have these properties since no distinction is made in the graphic or caption.
The graphic would be easier to understand if amphetamine were red like the trafficking paths. Same with the others. If using the same color makes the substance units somewhat indistinguishable the path, path thickness can be reduced or path color lightened.
Why is the vesicle wall (line) thickness different in the internal vesicle than the fused vesicle?
I wonder if "trace amine or amphetamine (in)" might graphically read better "trace amine (in) amphetamine (in)".
I muse over ways this schematic could keep the content but allow ordinary readers to grasp the basic mechanism without being daunted by the details. One consideration is altering the layout so the paths could be uncrossed as much as possible.
I'll leave it there for now. Box73 ( talk) 11:02, 18 November 2015 (UTC)