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Is "modulate the activity of (transforming growth factor beta) ligands" the appropriate way to describe the downstream mediators of a signal? 85.197.212.231 ( talk) 07:34, 7 April 2009 (UTC) reply

It would be really good to change some of these references to more up-to-date ones. Tannim101 ( talk) 19:46, 11 January 2010 (UTC) reply

Can someone add some history to it? E. g. when it was discovered and named? Logically it was discovered after MAD but it would be nice to at the least have the YEAR in the main article. 2A02:8388:1641:4700:BE5F:F4FF:FECD:7CB2 ( talk) 10:38, 13 May 2017 (UTC) reply

Subtopic, not independently notable Enterprisey ( talk!) 03:54, 24 September 2018 (UTC) reply

Oppose. R-SMAD is considered independently notable by MeSH. [1] Charles Matthews ( talk) 08:42, 15 September 2019 (UTC) reply