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Archive 1 |
The article states "like most atypical antipsychotics, Risperidone is used off-label for treatment of major depression." This is an over-generalization. Today, many psychiatrists in America hesitate to use atypical antipsychotics for major depression, limiting their off-label use for bipolar depression, not unipolar. Recently the makers of Abilify (apriprazole) began marketing their drug for treatment of major depression and the medical community has shown resistance, feeling that there are more tried and true methods to treating major (unipolar) depression. —Preceding unsigned comment added by 63.197.31.136 ( talk) 16:17, 11 April 2009 (UTC)
Risperidone is a very strong dopamine blocker (antagonist) that is to say it inhibits functioning of dopamine receptors. It reaches peak plasma levels quickly regardless of wheter it is administered as a liquid or pills. The strong dopamine-blocking reaction is known to make some people feel nauseous if you do anything that normally triggers the dopamine reward, such as eat a good meal or have sex. Risperidone is metabolised fairly quickly so this potential for nauseation subsides usually in two to three hours.
But this _is_ specific to Risperidone, since it has such a fast attack and it's such a strong dopamine blocker. Sure if you start with 0,5mg and after a week go to 1mg and after a week go to 2mg, which is the clinical dosage in these parts of the world at least, your neural nets will get adjusted as you go along.
If you think dopamine blockers are essential for your well being you should consult your phycician about getting on Olanzapine (expensive but works really nicely for most ppl) or if you're feeling suicidal or otherwise totally chaotic then Clozapine might work well. Also might want to consider googleing for "DHA fatty acids and scitthhzophreniernia or whatever the whitecoats diagnosed you with this time" There is propably something on this combo in the Lancet archive, but I'm too busy to dig it up now. Fatty fishes contain a good dosage of DHA. Happy healing. Tzuhou 10:45 Apr 15, 2003 (UTC)
Thanks for the edits, it's much better now. I'm totally schitzo. I've been through DSM-IV-TR (though ICD is the authority in this part of the world) playing white and black coat at the same time and I have to say that I've found numerous combinations to diagnose myself schitzo without even lying as playing white ;) but hey, that's life. Last time I was in the loonie bin they put me on valproic acid too, but I didn't like it much. It made me really apathic. Perphenazine is fun: you never know what is it this time, if you know what I mean ;) I used to play chess with this old guy that went to the ward once a month to get a 1mg injection of perphenazine. It's an amazing pharmaceutical *grin*. I take 16mg nowerdays and it actually works :) -- Tzuhou 00:06 Apr 16, 2003 (UTC)
BTW, I looked up Olanzapine and it is a dopamine blocker (as well as a blocker of several other neurotransmitters). -- RTC 00:37 Apr 16, 2003 (UTC)
I work with children with autism and some of them are prescribed risperidone. One particular child has STOPPED taking risperidone for around 3 months now. While on the drug he was happy and cheerful talked to staff alot and was very active. 3 months after stopping he has problems initiating movements and gets stuck in the middle of actions like getting dressed or stepping on to the pavement. Could this be a side effect of the risperidone or a side effect of its cessation? He is also far more fixated on certain songs or topics of conversation with respect to when he was on the drug. —Preceding unsigned comment added by 83.98.0.10 ( talk) 11:28, 9 October 2007 (UTC)
Thanks,
Gregorio-Smith ( talk) 18:56, 13 May 2008 (UTC)
Does anyone have access to information as to why there's no generic form of Risperdal sold? The stuff costs almost $500/mo for 4mg/day over 30 days.
There are no Risperdal generics available yet. As the patent for Risperidone is still in place. You could try getting the pills from your psych's office every month, since Risperdal does have sample boxes that last a month. Or you could get Risperdal available by injection, which lasts a long time. -- Moop stick 21:23, 22 January 2006 (UTC)
Risperdone is a generic for risperdal. Kazuba ( talk) 17:50, 16 September 2015 (UTC)
I have OCD and Asperger's, so I may be reading to much into this, but in referring to the Risperdal Conste, mentioning that it is vital given the large number of people with schizophrenia who are unwilling or unable to take their medicine, one may be applying the value judgement that schizophrenics and people with mental illnesses must take drugs. I certainly don't want schizophrenics to be hurt as a result of their schizophrenia, but injecting drugs that f*ck with a person's brain is a fairly serious action. I am not trying to editorialize, but there are plenty opposed to forced medication. More than likely I am reading a message that isn't there, and given the fact that I take Risperdal I do harbor some resentment towards it and many drugs in general, but I eagerly await your response. Thank you.
Iain Marcuson Imarcuso at Wikibooks.
-- Moop stick 01:33, 7 May 2006 (UTC)
What's wrong with the link to the Duke university webpage? I mean, the scientific citation is best, but I think it's also helpful to have a link to a more non-technical summary.
Further, what's wrong with clearly saying in the "side effects" section "Risperdal is correlated with pituitary tumors." You kind of buried that detail in another section, whereas I think that's a pretty big deal.
—The preceding unsigned comment was added by Fsk ( talk • contribs) 03:12, 4 June 2006.
I've updated the tumor stuff, with DukeMedNews as a Reference, not an External link. Colin° Talk 11:01, 4 June 2006 (UTC)
Trust me, I've had some prolactin troubles with Risperdal. It's not life threatening, and not signifigant enough to be put under as a safety risk. It's also been addressed in the "side effects" area. I also like this WebMD article better [1] . But I'll leave the issue up to someone else. -- Moop stick 03:32, 4 June 2006 (UTC)
I was trying to track the debates regarding the claims of increased stroke risk in older patients with dementia. Wasn't this a significant side effect claim that led to prescription advice altering in a number of juristictions? —Preceding
unsigned comment added by
82.153.251.65 (
talk) 10:26, 16 April 2009 (UTC)
You've really confused me now, Moop Stick. Why did you take off those two links just now? —The preceding unsigned comment was added by Fsk ( talk • contribs) 03:52, 4 June 2006.
The ones about Paliperidone? Because, Paliperidone isnt really related to Risperidone. Theyre just owned by the same company. Talk about Paliperidone shouldnt belong on this article. —The preceding unsigned comment was added by Moop stick ( talk • contribs) 04:51, 4 June 2006.
How did you know that Paliperidone isn't really related to Risperidone? —The preceding unsigned comment was added by Fsk ( talk • contribs) 05:08, 4 June 2006.
Paliperidone is the major active metabolite of risperidone, it is only differentiated from risperidone by the addition of one hydroxy group. Colin° Talk 11:01, 4 June 2006 (UTC)
Preferably the tumor information should link to the actual scientific article.
Also regarding paliperidone, it is simply a slightly more active form of risperidone and should probably be kept here, not as its own article, since Risperdal and the other brand names don't have separate articles. If, for example, paliperidone turns out to have significantly fewer side-effects, it might later deserve a separate article, but for now its not even on the market. Thatcher131 12:15, 4 June 2006 (UTC)
Can anyone tell me how long Risperidone stays in your system after you stop taking it?
Just wanted to add that you also have to taper off the dosing of the medication. The doctors warn that if you suddenly stop taking it, it can have very unwelcoming side effects much like those of drug rehab patients. 16:03, 22 April 2008 (UTC) —Preceding unsigned comment added by 24.113.101.242 ( talk)
His some of his edits might be useful, but he put it too prominently to the level that it would not be NPOV IMO. I would change the way he represented this; opinions are welcome. -- Samuel Curtis-- TALK 16:46, 1 November 2006 (UTC)
If you want to argue on your cause, please go on doing that on Schizophrenia. Any unproved statements in this article should be promptly removed per WP:VANDAL and to be reported to the admin as such.
Why should anti-psychiatrical arguments be taken to Schizophrenia? —Preceding unsigned comment added by 172.143.68.173 ( talk) 21:36, 14 December 2007 (UTC)
I agree mental disorders may be a cultural phenomenon and mental medications is a part of it, but this, any other mental medication articles, are not appropriate to discuss the merits of psychiatry. -- Samuel Curtis-- TALK 17:30, 11 November 2006 (UTC)
I'm planning to improve the Russian version of the article, and images would help. (0: Best regards, CopperKettle 10:48, 10 March 2007 (UTC)
The reference link to the FDA warning letter should be: http://www.fda.gov/foi/warning_letters/archive/g4628d.htm —The preceding unsigned comment was added by Robertri ( talk • contribs) 15:03, 2 May 2007 (UTC).
The article states, that Rispen is a brand name od risperidon preparation sold in the USA. I know Rispen only as a generic version of risperidone manufactured and distributed by the czech/slovak pharmaceutical company Zentiva. Is it really sold under this trade name in the US..? Most of the google hits for "Rispen+US" seems to take generously this information from this article.-- Spiperon 21:26, 3 May 2007 (UTC)
http://news.yahoo.com/s/ap/20070822/ap_on_he_me/psychotic_drug I think this should be added. —The preceding unsigned comment was added by 89.205.7.56 ( talk) 18:15, August 22, 2007 (UTC)
The psychiatrist who prescribes my Risperdal told me that many of the unpopular side effects of the drug, such as weight gain, only occur in doses of 4mg/day or more. I don't know the specifics, but I think that someone who has insight into this should change to article to reflect this. Bite the Wax Tadpole 21:28, 10 November 2007 (UTC)
92.235.205.104 ( talk) 03:25, 23 June 2010 (UTC) I have taken 1mg of Risperidone per day since February 2008 and have experienced gradual but constant weight gain. I believe this can be controlled by reducing the amount you eat, but that the drug does induce hunger. I would welcome other accounts of this. —Preceding unsigned comment added by 92.235.205.104 ( talk) 02:46, 23 June 2010 (UTC)
I think one of the extra pyramidal side effects is dry mouth and a feeling of thirst. Someone who consumes carbonated beverages high in sugar my unknowingly increase their intake significantly. I switched to diet soda due to this observation in my consumption of beverages and think it may be relevant to diabetes. —Preceding unsigned comment added by 64.53.203.180 ( talk) 01:10, 28 August 2010 (UTC)
In my experience, there are none, apart from the permanent losses of experience and the way that impacts on your life. And a short-ish period of three weeks to a month after cessation for the mental faculties to return. From at least one testimony I have found on a bulletin board, the return of faculties may vary from person to person... but the fact that in my case they came back seems to show that the drug is not responsible for any prolonged or permanent loss of the faculties. Since I think I only found one example of permanent loss perhaps it is not worth reporting.
On the one hand it would seem appropriate for an article like this to cite a study on long-term effects - perhaps someone could research? On the other hand my experience says it all really, probably more clearly and usefully than any convoluted study.
Anyone reading up on their medication will be crucially interested in this information. When I was on this med I was searching desperately on the web and found very little. I hope someone with more nouse will post what I have written on the main page. Personally I am inhibited by the scientific character of this page, but I appreciate there may be legal issues. Actually that was my main reason for not posting this. I imagine the big pharma breathing down the neck of wikipedia for example in including my comment about the "mental faculties returning", implying as it does (and truthfully) that mental faculties are blocked by the medication. That fact does not seem to enter the official literature/ leaflet that comes with the drug.
Anyone with half an eye on these words should be alert by now to the fact that I am drawing attention to a very real and important instance of public misinformation, which so far Wikipedia has shown no sign of addressing. I am talking about the loss of creativity, memory loss, loss of reasoning ability, verbal ability, and other higher thought processes. I do remember looking for this sort of information in the past and it is very hard to come by, you only find it scattered across various bulletin boards. Of course different people report different incidences of loss of each of the faculties I mentioned. But side-effects profiles are just as imprecise, and it is these primary effects which are most important of all. They should all be mentioned as potential effects of the drug.
Whether or not this information can be included on legal grounds I do not know, but someone should certainly post the info I provided about the long-term effects of risperidone. The news is good, it should hardly be controversial. It just needs rephrasing re: mental faculties returning. —Preceding unsigned comment added by 79.69.65.238 ( talk) 19:54, 20 December 2007 (UTC)
I agree the facts on effects are light, could you be more specific in your use of mental faculty? —Preceding unsigned comment added by 64.53.203.180 ( talk) 01:06, 28 August 2010 (UTC)
While generic risperidone is not expeted at US pharmacies until after June 2008, legitimate Canadian pharmacies have generic risperidone available now, and do ship to the US. One should be careful not to use an email spam to find such a pharmacy. A prescription that would cost $800 at a US pharmacy may be available for $100 from Canada. Manufacturers of the generic include known companies such as Sandoz. A written prescription from your psychiatrist is required. The Canadian pharmacy may require that the prescription be mailed to them, however, in some cases a FAX is acceptable. 69.110.0.187 ( talk) 06:01, 18 February 2008 (UTC)
Not directed to improving article. Collapsed.-- Garrondo ( talk) 10:51, 19 May 2013 (UTC)
"It also helps the physician ensure compliance" -- scary —Preceding unsigned comment added by 66.188.187.164 ( talk) 01:13, 27 April 2008 (UTC)
Not scary at all. Believe it or not, many psychotic people believe nothing is wrong with them, and therefore try to avoid taking medication when in fact they really need it... Giltramirez ( talk) 21:10, 7 November 2011 (UTC)
Bull crap Giltramirez..... Schizophrenia is just name calling and also there is no such thing as a hallucination for the spirit world is real and demons truly exist. The Holy Scriptures says in Thessalonians that Christians have a struggling against the wicked spirit forces in the heavenly places and against the world rulers of this darkness. Sounds a lot like many who have been stuck in psychwards like me. Both a struggling with the demons and the government who put me there so afraid of the demons. 2602:306:C518:6C40:61B1:B9B8:E848:31A7 ( talk) 03:14, 13 May 2013 (UTC)Risperidone, does not block dopamine receptors as stated in the article. It blocks a class of 5-HT (serotonin) recpetors which are linked to weight gain (5-HT2C), its antipsychotic action (5-HT2A) and relief of some of the extrapyramidal side effects experienced with the Typical neuroleptics. The latter action, in fact, leads to an increased release of Dopamine from Mesocortical neurones. Striate —Preceding unsigned comment added by 77.103.15.54 ( talk) 19:36, 14 May 2008 (UTC)
Speaking of Sexual Side effects it seems to me there should be some mention of the link between hyperprolactinemia (prolactin increase) and it's effects on fertility not just on pituitary tumors.. It seems relevant to understand that that may be a side effect especially in women. Sometimes when a doctor describes using this medication as a prophylactic measure it may have a double meaning... "Often the family physician has to deal with lack of cooperation from patients [with schizophrenia] when they are asked to use common forms of contraception. [As a contraceptive measure for such patients,] some family physicians rely on the infertility secondary to hyperprolactinemia caused by traditional antipsychotic agents"
from Kaplan B, Modai I, Stoler M, et al: Clozapine treatment and the risk of unplanned pregnancy. Journal of the American Board of Family Practice 8:239-241, 1995
I would appreciate some consideration of these side effects on the main page especially considering the high levels of hyperprolactinemia induced by Risperidone. Thank You. Clayoismynamo ( talk) 18:49, 27 September 2008 (UTC)
Perhaps there should be a cross-link to the article on Invega, which is the active metabolite of risperidone recently patented by Janssen as a separate drug. Expert assistance requested. DQweny ( talk) 20:51, 18 October 2009 (UTC)
I was treated with Risperidone for PTSD. I didn't see anything that said it was FDA approved for it or it may help it. Has anyone been on it for PTSD? Can it be treated for PTSD?
I take it for other reason's but I believe it can be effective for PTSD. Although I won't explain why this may be useful because I'd be speculating on mechanism of actions from an uneducated position. —Preceding unsigned comment added by 64.53.203.180 ( talk) 01:14, 28 August 2010 (UTC)
First of all, is this true? Can Risperidone be obtained LEGALLY without prescription? Second, if not, who should I inform about all these on-lines sites that advertise the sale of R. WITHOUT prescription? This is insane! -- Francesco Franco ( talk) 09:26, 23 November 2009 (UTC)
My grandson has been taking respiridol .5mg m-tabs for about 6 months. He has a hard time swallowing pills. Just wondering, can the .5mg pill be dissolved or chewed? He is supposed to start taking it. —Preceding unsigned comment added by 206.190.231.66 ( talk) 13:23, 6 January 2010 (UTC)
There is an M-Tab available which is the pill that dissolves in your mouth. A word of caution- be VERY careful with this drug, especially if your grandson is young because I wish I had someone looking out for me when they put me on this poison that is known as Risperdal. I was on it for like 10 months and that 10 months seemed like an eternity in Hell- I really don't know how I stayed on it for as long as I did, other than I was just doing what the doctors told me. That whole experience taught me that just because a doctor or someone with a degree tells you that you need to take something, it doesn't mean shit because no one's word is golden except God's and they're not God. I was switched to Abilify for a while and that drug was A LOT better than Risperdal but at the same time, it wasn't good, so eventually I just stopped taking that. Since the beginning of this year I haven't taken any medications and I feel better than I've felt in a long time- I have no schizophrenic symptoms whatsoever and I feel better off the meds than I ever felt on them; I question if I really have schizophrenia because I was only diagnosed with schizophreniform disorder and the only time I've ever had symptoms related to schizophrenia is after I smoked marijuana (safe to say, I don't touch the stuff anymore- I'm not saying the weed caused my psychosis but I'd be kidding myself if I said it didn't play a huge role in it). I kind of went off on a rant but I'm just trying to help out someone because like I said before, I wish someone told me about all the horrible side effects and general effects that Risperdal causes/can cause.
my dad got diabetes when a doctor (putting a 250 pound man on this should get him kicked out of the profession ) put him on this drug-off label for depression (he weighted 250 pounds at the time, now 8 years after contracting diabetes he is 300). This drug gives people diabetes. I went on it for OCD and now have low blood sugar. MY dad and i both went on it off-label and he was overweight at the time and 50, i was 170 pound 6"3' 18 year old. It gave him hyperglycemia (diabetes) and me hypoglycemia!
We are both disabled for the rest of our lives because of this shit medication. The people at jansen pharmaceuticals ruined the lives of two people for hundred of dollars in drug revenue. Peppermintschnapps ( talk) 21:01, 21 January 2010 (UTC)
Recently, the following two links were added to the article:
http://www.resource4risperdalinfo.com
http://www.yourlawyer.com/topics/overview/pituitary_tumors
Both of these links are to the promotion pages for lawyers working on risperidal personal injury cases. These sources are non-reliable, questionable sources according to the Wikipedia:Verifiability: "Questionable sources are those with a poor reputation for checking the facts, or with no editorial oversight. Such sources include websites and publications expressing views that are ... promotional in nature." These sources must be deleted and replaced by peer reviewed scientific references. The Sceptical Chymist ( talk) 17:11, 24 January 2010 (UTC)
You do realise that legal websites aren't likely to lie about medicinal statistics, as they themselves don't want to be discredited and in the path of a lawsuit from the pharmaceuticals. I'm sure if they were challenged they could pull all the reliable sources they needed. You're very good at removing sources and putting in citation tags, often where they aren't needed, but if you can't actually find more reliable citations to replace these, then don't. Furthermore, I brought in a third opinion from Literaturegeek | T@1k?, and he wouldn't have removed those sources, but perhaps added another source instead, to complement these sources, rather than just a citation tag replacement. Editor182 ( talk) 23:56, 25 January 2010 (UTC)
The first question that arises from this is why is an adult being treated like a child?
This kind of forced drugging discrminates against people who are unable to afford to leave the country during the period in which the psychiatrist is pursuing forcing them onto medications. Is this what we're striving for?
I find Wikipedia to be informative and use it as a regular source of information. However this article seems light on how this medication works, what parts of the brain it could possibly affect and how it relates to it's medicinal properties. I will attempt some research and would greatly appreciate anyone with some knowledge on this matter. There seems to be a trend, that the more commercial a medicine is the less is known about its mechanism of action and effects on brain function. Does anyone have suggestions as to a good starting place to find relevant information regarding this? —Preceding unsigned comment added by 64.53.203.180 ( talk) 00:58, 28 August 2010 (UTC)
Maybe, risperdal has brain boosting powers & can be used to enhance interlectuality of an individual. Allanmucheru ( talk) 14:47, 20 June 2016 (UTC)
There needs to be a section on how this chemical is synthesized. 2602:306:C518:62C0:5C06:758E:E477:60D6 ( talk) 23:13, 31 July 2012 (UTC)
http://www.drugsyn.org/Risperidone.htm — Preceding unsigned comment added by 2602:306:C518:6C40:61B1:B9B8:E848:31A7 ( talk) 01:06, 13 May 2013 (UTC)
Someone needs to lift the drug synthesis information from this site and add it to Wikipedia articles with attribution. All these molecular building blocks need articles of their own also. 2602:306:C518:6C40:61B1:B9B8:E848:31A7 ( talk) 02:17, 13 May 2013 (UTC)
i. Aluminum chloride, dichloromethane, room temperature, 3 h, ii. 6N hydrochloric acid, reflux, 5 h, iii. Hydroxylamine hydrochloride, ethanol, N,N-diethylenethanamine, reflux, 3 h, iv. Potassium hydroxide, water, reflux, 2 h, v. [[3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one hydrochloride]], potassium iodide, sodium carbonate, N,N-dimethylformamide, 85 - 90 °C, overnight
Preparation of Risperidone is described in US patent 4,804,663 and and also in European Patent EP196132. Accordingly, 1,3-difluorobenzene 1 and 1-acetylpiperidine-4-carbonyl chloride 2 were reacted in presence of aluminum chloride using dichloromethane as solvent at ambient temperature to give [[1-[4-(2,4-difluorobenzoyl)-1-piperidyl]ethanone]] 3. The compound 3 was further hydrolyzed by heating with 6N hydrochloric acid at reflux temperature to give (2,4-difluorophenyl)-(4-piperidyl)methanone 4. Compound 4 was then treated with Hydroxylamine hydrochloride in presence of N,N-diethylenethanamine as base using ethanol as solvent at reflux temperature to give (2,4-difluorophenyl)-(4-piperidyl)methanone oxime 5. Compound 5 on was then cyclized by stirring with potassium hydroxide using water as solvent at reflux temperature resulting in to 6-fluoro-3-(4-piperidyl)-1,2-benzoxazole 6. The final step involves condensation of 6 with [[3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one hydrochloride]] in presence of potassium iodide and sodium carbonate as base using N,N-dimethylformamide as solvent at elevated temperature to afford 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)-1-piperidyl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one also called Risperidone 7.
its the leas potent antipsychotic Qwh ( talk) 10:04, 9 May 2013 (UTC).
Yes in many ways its quite a nice drug, with much less weight gain than Olanzapine, and it gives you a nice little lick when you take each oral tablet, which may help you change town, get a new job, flat or go to college or back to it. Late at night mixed with too much liquor and caffine, ie coffee, red bull it may make you a bit too loud and lippy. More than 1mg a day reduces sperm and with 4mg it will be minimal and 5mg close to zero, but generally this drug actually helps people have good sex. — Preceding unsigned comment added by 60.234.54.147 ( talk) 03:27, 9 September 2014 (UTC)
Innapproiate wording close to disruptive. Also unsorced. Collapsed per guidelines about talk pages, but we could discuss anosmia as a side effect if sources are found. -- Garrondo ( talk) 06:51, 21 May 2013 (UTC)
Posted here to arrive at consensus. Risperidone destroys sense of smell. You can not even smell your own feces or a dirty bathroom after being exposed to this medicine. The danger is you could end up drinking sour milk or go down on a dirty wife who has not washed herself. We have a sense of smell for a reason to protect us and prevent us from eating something rotten or dirty. 2602:306:C518:6C40:F02A:330C:11CC:ACDB ( talk) 06:06, 21 May 2013 (UTC)
What do these receptors, associated with gastric acid secretion, have to do with the nervous system? — Preceding unsigned comment added by 00AgentBond93 ( talk • contribs) 13:05, 14 August 2013 (UTC)
Can anyone chack this edit? I reverted it but am not sure. Super48paul ( talk) 14:09, 22 September 2013 (UTC)
Side effects seem self serving to the drug manufacturer by only listin FDA approval testing side effects. Currently many lawsuits re breast growth in teen boys (gynomastia). [1] [2] [3] [4] [5] [6] Shjacks45 ( talk) 00:06, 27 September 2013 (UTC)
Most of these TV commercials are lawsuits that don't seem to be the honest and complete truth. Where are the links for the lawsuits? 64.113.124.158 ( talk) 23:42, 30 September 2013 (UTC)
References
Could anyone add dysphoria as side effect, and muscle stiffness as they were there earlier? 78.156.109.166 ( talk) 09:18, 24 October 2013 (UTC)
I'm Autistic and I'm irritable. As a matter of fact, I'm pissed. DON'T give Autistic folks drugs!! Autistic brains are fine as they are. We have a right to be "irritable." — Preceding unsigned comment added by 72.70.192.193 ( talk) 06:37, 16 December 2014 (UTC)
need to know
I understand we may have some people who work for J&J who think this isn't an issue but there's plenty of evidence and lawsuits that something is going on and it's clearly being pushed to the sidelines by people who edit this page. I'm not entirely sure why this is happening or why people are choosing to do it, but I'm going to leave this up here until this is settled. If nobody can give me a good reason to refute a federal study and a volume of evidence that there's litigation and the possibility of developing Gynecomastia from taking the drug, then I'm reporting the fact that someone is censoring it. Twice I've made the edit and twice it's been censored and it's apparent that someone doesn't want this going up here. — Preceding unsigned comment added by 108.48.66.91 ( talk) 02:31, 28 February 2018 (UTC)
"In many respects, this medication can be useful as an "acetylcholine release-promoter" similar to gastrointestinal drugs such as metoclopramide and cisapride. " Any sources confirming this statement? what is the difference between "releaser" and "release-promoter" see this -> /info/en/?search=Alpha-2_adrenergic_receptor#Individual Can anybody describe the machanism of this drug which promote acetylcholine release? I mean any proof of that statement— Preceding unsigned comment added by 178.235.88.248 ( talk) 18:38, 11 July 2018 (UTC)
This ref supports the common side effects. Not sure why it was removed?
https://www.drugs.com/monograph/risperidone.html
Doc James ( talk · contribs · email) 03:08, 24 October 2018 (UTC)
The drugs.com link is to the "American Society of Health-System Pharmacists"
You do realize that the medlineplus link https://medlineplus.gov/druginfo/meds/a698019.html is also from the "American Society of Health-System Pharmacists"?
Drugs.com and the NIH have both bought licenses for it. The first is the professional version and the medlineplus one is the patient version. Doc James ( talk · contribs · email) 03:47, 27 October 2018 (UTC)
Galactorrhea and gynecomastia are very common side effects. It should be mentioned in this article because these side effects are said to be rare when taking atypical antipsychotics like risperidone is. As far as I know there have even been lawsuits in the USA because of gynecomastia in young male adolescents. Gynecomastia in males cannot be reversed except by surgery.
Risperidone is even mentioned in wikipedia as "[being] notorious for causing" galactorrhea: "Of these, risperidone is the most notorious for causing this complication." See here: /info/en/?search=Galactorrhea
Source according to this article on wikipedia: Popli, A (March 1998). "Risperidone-induced galactorrhea associated with a prolactin elevation". Ann Clin Psychiatry. 10 (1): 31–3. doi:10.3109/10401239809148815. PMID 9622047. 2001:16B8:C2C3:F400:29C9:AF5:D68:4671 ( talk) 10:44, 14 September 2021 (UTC)
Who actually synthesised this drug first I'm quite interested to know who the chemist responsible for the creation of the compound is and what else they may have created? 103.69.253.9 ( talk) 13:04, 23 November 2021 (UTC)
This is an archive of past discussions. Do not edit the contents of this page. If you wish to start a new discussion or revive an old one, please do so on the current talk page. |
Archive 1 |
The article states "like most atypical antipsychotics, Risperidone is used off-label for treatment of major depression." This is an over-generalization. Today, many psychiatrists in America hesitate to use atypical antipsychotics for major depression, limiting their off-label use for bipolar depression, not unipolar. Recently the makers of Abilify (apriprazole) began marketing their drug for treatment of major depression and the medical community has shown resistance, feeling that there are more tried and true methods to treating major (unipolar) depression. —Preceding unsigned comment added by 63.197.31.136 ( talk) 16:17, 11 April 2009 (UTC)
Risperidone is a very strong dopamine blocker (antagonist) that is to say it inhibits functioning of dopamine receptors. It reaches peak plasma levels quickly regardless of wheter it is administered as a liquid or pills. The strong dopamine-blocking reaction is known to make some people feel nauseous if you do anything that normally triggers the dopamine reward, such as eat a good meal or have sex. Risperidone is metabolised fairly quickly so this potential for nauseation subsides usually in two to three hours.
But this _is_ specific to Risperidone, since it has such a fast attack and it's such a strong dopamine blocker. Sure if you start with 0,5mg and after a week go to 1mg and after a week go to 2mg, which is the clinical dosage in these parts of the world at least, your neural nets will get adjusted as you go along.
If you think dopamine blockers are essential for your well being you should consult your phycician about getting on Olanzapine (expensive but works really nicely for most ppl) or if you're feeling suicidal or otherwise totally chaotic then Clozapine might work well. Also might want to consider googleing for "DHA fatty acids and scitthhzophreniernia or whatever the whitecoats diagnosed you with this time" There is propably something on this combo in the Lancet archive, but I'm too busy to dig it up now. Fatty fishes contain a good dosage of DHA. Happy healing. Tzuhou 10:45 Apr 15, 2003 (UTC)
Thanks for the edits, it's much better now. I'm totally schitzo. I've been through DSM-IV-TR (though ICD is the authority in this part of the world) playing white and black coat at the same time and I have to say that I've found numerous combinations to diagnose myself schitzo without even lying as playing white ;) but hey, that's life. Last time I was in the loonie bin they put me on valproic acid too, but I didn't like it much. It made me really apathic. Perphenazine is fun: you never know what is it this time, if you know what I mean ;) I used to play chess with this old guy that went to the ward once a month to get a 1mg injection of perphenazine. It's an amazing pharmaceutical *grin*. I take 16mg nowerdays and it actually works :) -- Tzuhou 00:06 Apr 16, 2003 (UTC)
BTW, I looked up Olanzapine and it is a dopamine blocker (as well as a blocker of several other neurotransmitters). -- RTC 00:37 Apr 16, 2003 (UTC)
I work with children with autism and some of them are prescribed risperidone. One particular child has STOPPED taking risperidone for around 3 months now. While on the drug he was happy and cheerful talked to staff alot and was very active. 3 months after stopping he has problems initiating movements and gets stuck in the middle of actions like getting dressed or stepping on to the pavement. Could this be a side effect of the risperidone or a side effect of its cessation? He is also far more fixated on certain songs or topics of conversation with respect to when he was on the drug. —Preceding unsigned comment added by 83.98.0.10 ( talk) 11:28, 9 October 2007 (UTC)
Thanks,
Gregorio-Smith ( talk) 18:56, 13 May 2008 (UTC)
Does anyone have access to information as to why there's no generic form of Risperdal sold? The stuff costs almost $500/mo for 4mg/day over 30 days.
There are no Risperdal generics available yet. As the patent for Risperidone is still in place. You could try getting the pills from your psych's office every month, since Risperdal does have sample boxes that last a month. Or you could get Risperdal available by injection, which lasts a long time. -- Moop stick 21:23, 22 January 2006 (UTC)
Risperdone is a generic for risperdal. Kazuba ( talk) 17:50, 16 September 2015 (UTC)
I have OCD and Asperger's, so I may be reading to much into this, but in referring to the Risperdal Conste, mentioning that it is vital given the large number of people with schizophrenia who are unwilling or unable to take their medicine, one may be applying the value judgement that schizophrenics and people with mental illnesses must take drugs. I certainly don't want schizophrenics to be hurt as a result of their schizophrenia, but injecting drugs that f*ck with a person's brain is a fairly serious action. I am not trying to editorialize, but there are plenty opposed to forced medication. More than likely I am reading a message that isn't there, and given the fact that I take Risperdal I do harbor some resentment towards it and many drugs in general, but I eagerly await your response. Thank you.
Iain Marcuson Imarcuso at Wikibooks.
-- Moop stick 01:33, 7 May 2006 (UTC)
What's wrong with the link to the Duke university webpage? I mean, the scientific citation is best, but I think it's also helpful to have a link to a more non-technical summary.
Further, what's wrong with clearly saying in the "side effects" section "Risperdal is correlated with pituitary tumors." You kind of buried that detail in another section, whereas I think that's a pretty big deal.
—The preceding unsigned comment was added by Fsk ( talk • contribs) 03:12, 4 June 2006.
I've updated the tumor stuff, with DukeMedNews as a Reference, not an External link. Colin° Talk 11:01, 4 June 2006 (UTC)
Trust me, I've had some prolactin troubles with Risperdal. It's not life threatening, and not signifigant enough to be put under as a safety risk. It's also been addressed in the "side effects" area. I also like this WebMD article better [1] . But I'll leave the issue up to someone else. -- Moop stick 03:32, 4 June 2006 (UTC)
I was trying to track the debates regarding the claims of increased stroke risk in older patients with dementia. Wasn't this a significant side effect claim that led to prescription advice altering in a number of juristictions? —Preceding
unsigned comment added by
82.153.251.65 (
talk) 10:26, 16 April 2009 (UTC)
You've really confused me now, Moop Stick. Why did you take off those two links just now? —The preceding unsigned comment was added by Fsk ( talk • contribs) 03:52, 4 June 2006.
The ones about Paliperidone? Because, Paliperidone isnt really related to Risperidone. Theyre just owned by the same company. Talk about Paliperidone shouldnt belong on this article. —The preceding unsigned comment was added by Moop stick ( talk • contribs) 04:51, 4 June 2006.
How did you know that Paliperidone isn't really related to Risperidone? —The preceding unsigned comment was added by Fsk ( talk • contribs) 05:08, 4 June 2006.
Paliperidone is the major active metabolite of risperidone, it is only differentiated from risperidone by the addition of one hydroxy group. Colin° Talk 11:01, 4 June 2006 (UTC)
Preferably the tumor information should link to the actual scientific article.
Also regarding paliperidone, it is simply a slightly more active form of risperidone and should probably be kept here, not as its own article, since Risperdal and the other brand names don't have separate articles. If, for example, paliperidone turns out to have significantly fewer side-effects, it might later deserve a separate article, but for now its not even on the market. Thatcher131 12:15, 4 June 2006 (UTC)
Can anyone tell me how long Risperidone stays in your system after you stop taking it?
Just wanted to add that you also have to taper off the dosing of the medication. The doctors warn that if you suddenly stop taking it, it can have very unwelcoming side effects much like those of drug rehab patients. 16:03, 22 April 2008 (UTC) —Preceding unsigned comment added by 24.113.101.242 ( talk)
His some of his edits might be useful, but he put it too prominently to the level that it would not be NPOV IMO. I would change the way he represented this; opinions are welcome. -- Samuel Curtis-- TALK 16:46, 1 November 2006 (UTC)
If you want to argue on your cause, please go on doing that on Schizophrenia. Any unproved statements in this article should be promptly removed per WP:VANDAL and to be reported to the admin as such.
Why should anti-psychiatrical arguments be taken to Schizophrenia? —Preceding unsigned comment added by 172.143.68.173 ( talk) 21:36, 14 December 2007 (UTC)
I agree mental disorders may be a cultural phenomenon and mental medications is a part of it, but this, any other mental medication articles, are not appropriate to discuss the merits of psychiatry. -- Samuel Curtis-- TALK 17:30, 11 November 2006 (UTC)
I'm planning to improve the Russian version of the article, and images would help. (0: Best regards, CopperKettle 10:48, 10 March 2007 (UTC)
The reference link to the FDA warning letter should be: http://www.fda.gov/foi/warning_letters/archive/g4628d.htm —The preceding unsigned comment was added by Robertri ( talk • contribs) 15:03, 2 May 2007 (UTC).
The article states, that Rispen is a brand name od risperidon preparation sold in the USA. I know Rispen only as a generic version of risperidone manufactured and distributed by the czech/slovak pharmaceutical company Zentiva. Is it really sold under this trade name in the US..? Most of the google hits for "Rispen+US" seems to take generously this information from this article.-- Spiperon 21:26, 3 May 2007 (UTC)
http://news.yahoo.com/s/ap/20070822/ap_on_he_me/psychotic_drug I think this should be added. —The preceding unsigned comment was added by 89.205.7.56 ( talk) 18:15, August 22, 2007 (UTC)
The psychiatrist who prescribes my Risperdal told me that many of the unpopular side effects of the drug, such as weight gain, only occur in doses of 4mg/day or more. I don't know the specifics, but I think that someone who has insight into this should change to article to reflect this. Bite the Wax Tadpole 21:28, 10 November 2007 (UTC)
92.235.205.104 ( talk) 03:25, 23 June 2010 (UTC) I have taken 1mg of Risperidone per day since February 2008 and have experienced gradual but constant weight gain. I believe this can be controlled by reducing the amount you eat, but that the drug does induce hunger. I would welcome other accounts of this. —Preceding unsigned comment added by 92.235.205.104 ( talk) 02:46, 23 June 2010 (UTC)
I think one of the extra pyramidal side effects is dry mouth and a feeling of thirst. Someone who consumes carbonated beverages high in sugar my unknowingly increase their intake significantly. I switched to diet soda due to this observation in my consumption of beverages and think it may be relevant to diabetes. —Preceding unsigned comment added by 64.53.203.180 ( talk) 01:10, 28 August 2010 (UTC)
In my experience, there are none, apart from the permanent losses of experience and the way that impacts on your life. And a short-ish period of three weeks to a month after cessation for the mental faculties to return. From at least one testimony I have found on a bulletin board, the return of faculties may vary from person to person... but the fact that in my case they came back seems to show that the drug is not responsible for any prolonged or permanent loss of the faculties. Since I think I only found one example of permanent loss perhaps it is not worth reporting.
On the one hand it would seem appropriate for an article like this to cite a study on long-term effects - perhaps someone could research? On the other hand my experience says it all really, probably more clearly and usefully than any convoluted study.
Anyone reading up on their medication will be crucially interested in this information. When I was on this med I was searching desperately on the web and found very little. I hope someone with more nouse will post what I have written on the main page. Personally I am inhibited by the scientific character of this page, but I appreciate there may be legal issues. Actually that was my main reason for not posting this. I imagine the big pharma breathing down the neck of wikipedia for example in including my comment about the "mental faculties returning", implying as it does (and truthfully) that mental faculties are blocked by the medication. That fact does not seem to enter the official literature/ leaflet that comes with the drug.
Anyone with half an eye on these words should be alert by now to the fact that I am drawing attention to a very real and important instance of public misinformation, which so far Wikipedia has shown no sign of addressing. I am talking about the loss of creativity, memory loss, loss of reasoning ability, verbal ability, and other higher thought processes. I do remember looking for this sort of information in the past and it is very hard to come by, you only find it scattered across various bulletin boards. Of course different people report different incidences of loss of each of the faculties I mentioned. But side-effects profiles are just as imprecise, and it is these primary effects which are most important of all. They should all be mentioned as potential effects of the drug.
Whether or not this information can be included on legal grounds I do not know, but someone should certainly post the info I provided about the long-term effects of risperidone. The news is good, it should hardly be controversial. It just needs rephrasing re: mental faculties returning. —Preceding unsigned comment added by 79.69.65.238 ( talk) 19:54, 20 December 2007 (UTC)
I agree the facts on effects are light, could you be more specific in your use of mental faculty? —Preceding unsigned comment added by 64.53.203.180 ( talk) 01:06, 28 August 2010 (UTC)
While generic risperidone is not expeted at US pharmacies until after June 2008, legitimate Canadian pharmacies have generic risperidone available now, and do ship to the US. One should be careful not to use an email spam to find such a pharmacy. A prescription that would cost $800 at a US pharmacy may be available for $100 from Canada. Manufacturers of the generic include known companies such as Sandoz. A written prescription from your psychiatrist is required. The Canadian pharmacy may require that the prescription be mailed to them, however, in some cases a FAX is acceptable. 69.110.0.187 ( talk) 06:01, 18 February 2008 (UTC)
Not directed to improving article. Collapsed.-- Garrondo ( talk) 10:51, 19 May 2013 (UTC)
"It also helps the physician ensure compliance" -- scary —Preceding unsigned comment added by 66.188.187.164 ( talk) 01:13, 27 April 2008 (UTC)
Not scary at all. Believe it or not, many psychotic people believe nothing is wrong with them, and therefore try to avoid taking medication when in fact they really need it... Giltramirez ( talk) 21:10, 7 November 2011 (UTC)
Bull crap Giltramirez..... Schizophrenia is just name calling and also there is no such thing as a hallucination for the spirit world is real and demons truly exist. The Holy Scriptures says in Thessalonians that Christians have a struggling against the wicked spirit forces in the heavenly places and against the world rulers of this darkness. Sounds a lot like many who have been stuck in psychwards like me. Both a struggling with the demons and the government who put me there so afraid of the demons. 2602:306:C518:6C40:61B1:B9B8:E848:31A7 ( talk) 03:14, 13 May 2013 (UTC)Risperidone, does not block dopamine receptors as stated in the article. It blocks a class of 5-HT (serotonin) recpetors which are linked to weight gain (5-HT2C), its antipsychotic action (5-HT2A) and relief of some of the extrapyramidal side effects experienced with the Typical neuroleptics. The latter action, in fact, leads to an increased release of Dopamine from Mesocortical neurones. Striate —Preceding unsigned comment added by 77.103.15.54 ( talk) 19:36, 14 May 2008 (UTC)
Speaking of Sexual Side effects it seems to me there should be some mention of the link between hyperprolactinemia (prolactin increase) and it's effects on fertility not just on pituitary tumors.. It seems relevant to understand that that may be a side effect especially in women. Sometimes when a doctor describes using this medication as a prophylactic measure it may have a double meaning... "Often the family physician has to deal with lack of cooperation from patients [with schizophrenia] when they are asked to use common forms of contraception. [As a contraceptive measure for such patients,] some family physicians rely on the infertility secondary to hyperprolactinemia caused by traditional antipsychotic agents"
from Kaplan B, Modai I, Stoler M, et al: Clozapine treatment and the risk of unplanned pregnancy. Journal of the American Board of Family Practice 8:239-241, 1995
I would appreciate some consideration of these side effects on the main page especially considering the high levels of hyperprolactinemia induced by Risperidone. Thank You. Clayoismynamo ( talk) 18:49, 27 September 2008 (UTC)
Perhaps there should be a cross-link to the article on Invega, which is the active metabolite of risperidone recently patented by Janssen as a separate drug. Expert assistance requested. DQweny ( talk) 20:51, 18 October 2009 (UTC)
I was treated with Risperidone for PTSD. I didn't see anything that said it was FDA approved for it or it may help it. Has anyone been on it for PTSD? Can it be treated for PTSD?
I take it for other reason's but I believe it can be effective for PTSD. Although I won't explain why this may be useful because I'd be speculating on mechanism of actions from an uneducated position. —Preceding unsigned comment added by 64.53.203.180 ( talk) 01:14, 28 August 2010 (UTC)
First of all, is this true? Can Risperidone be obtained LEGALLY without prescription? Second, if not, who should I inform about all these on-lines sites that advertise the sale of R. WITHOUT prescription? This is insane! -- Francesco Franco ( talk) 09:26, 23 November 2009 (UTC)
My grandson has been taking respiridol .5mg m-tabs for about 6 months. He has a hard time swallowing pills. Just wondering, can the .5mg pill be dissolved or chewed? He is supposed to start taking it. —Preceding unsigned comment added by 206.190.231.66 ( talk) 13:23, 6 January 2010 (UTC)
There is an M-Tab available which is the pill that dissolves in your mouth. A word of caution- be VERY careful with this drug, especially if your grandson is young because I wish I had someone looking out for me when they put me on this poison that is known as Risperdal. I was on it for like 10 months and that 10 months seemed like an eternity in Hell- I really don't know how I stayed on it for as long as I did, other than I was just doing what the doctors told me. That whole experience taught me that just because a doctor or someone with a degree tells you that you need to take something, it doesn't mean shit because no one's word is golden except God's and they're not God. I was switched to Abilify for a while and that drug was A LOT better than Risperdal but at the same time, it wasn't good, so eventually I just stopped taking that. Since the beginning of this year I haven't taken any medications and I feel better than I've felt in a long time- I have no schizophrenic symptoms whatsoever and I feel better off the meds than I ever felt on them; I question if I really have schizophrenia because I was only diagnosed with schizophreniform disorder and the only time I've ever had symptoms related to schizophrenia is after I smoked marijuana (safe to say, I don't touch the stuff anymore- I'm not saying the weed caused my psychosis but I'd be kidding myself if I said it didn't play a huge role in it). I kind of went off on a rant but I'm just trying to help out someone because like I said before, I wish someone told me about all the horrible side effects and general effects that Risperdal causes/can cause.
my dad got diabetes when a doctor (putting a 250 pound man on this should get him kicked out of the profession ) put him on this drug-off label for depression (he weighted 250 pounds at the time, now 8 years after contracting diabetes he is 300). This drug gives people diabetes. I went on it for OCD and now have low blood sugar. MY dad and i both went on it off-label and he was overweight at the time and 50, i was 170 pound 6"3' 18 year old. It gave him hyperglycemia (diabetes) and me hypoglycemia!
We are both disabled for the rest of our lives because of this shit medication. The people at jansen pharmaceuticals ruined the lives of two people for hundred of dollars in drug revenue. Peppermintschnapps ( talk) 21:01, 21 January 2010 (UTC)
Recently, the following two links were added to the article:
http://www.resource4risperdalinfo.com
http://www.yourlawyer.com/topics/overview/pituitary_tumors
Both of these links are to the promotion pages for lawyers working on risperidal personal injury cases. These sources are non-reliable, questionable sources according to the Wikipedia:Verifiability: "Questionable sources are those with a poor reputation for checking the facts, or with no editorial oversight. Such sources include websites and publications expressing views that are ... promotional in nature." These sources must be deleted and replaced by peer reviewed scientific references. The Sceptical Chymist ( talk) 17:11, 24 January 2010 (UTC)
You do realise that legal websites aren't likely to lie about medicinal statistics, as they themselves don't want to be discredited and in the path of a lawsuit from the pharmaceuticals. I'm sure if they were challenged they could pull all the reliable sources they needed. You're very good at removing sources and putting in citation tags, often where they aren't needed, but if you can't actually find more reliable citations to replace these, then don't. Furthermore, I brought in a third opinion from Literaturegeek | T@1k?, and he wouldn't have removed those sources, but perhaps added another source instead, to complement these sources, rather than just a citation tag replacement. Editor182 ( talk) 23:56, 25 January 2010 (UTC)
The first question that arises from this is why is an adult being treated like a child?
This kind of forced drugging discrminates against people who are unable to afford to leave the country during the period in which the psychiatrist is pursuing forcing them onto medications. Is this what we're striving for?
I find Wikipedia to be informative and use it as a regular source of information. However this article seems light on how this medication works, what parts of the brain it could possibly affect and how it relates to it's medicinal properties. I will attempt some research and would greatly appreciate anyone with some knowledge on this matter. There seems to be a trend, that the more commercial a medicine is the less is known about its mechanism of action and effects on brain function. Does anyone have suggestions as to a good starting place to find relevant information regarding this? —Preceding unsigned comment added by 64.53.203.180 ( talk) 00:58, 28 August 2010 (UTC)
Maybe, risperdal has brain boosting powers & can be used to enhance interlectuality of an individual. Allanmucheru ( talk) 14:47, 20 June 2016 (UTC)
There needs to be a section on how this chemical is synthesized. 2602:306:C518:62C0:5C06:758E:E477:60D6 ( talk) 23:13, 31 July 2012 (UTC)
http://www.drugsyn.org/Risperidone.htm — Preceding unsigned comment added by 2602:306:C518:6C40:61B1:B9B8:E848:31A7 ( talk) 01:06, 13 May 2013 (UTC)
Someone needs to lift the drug synthesis information from this site and add it to Wikipedia articles with attribution. All these molecular building blocks need articles of their own also. 2602:306:C518:6C40:61B1:B9B8:E848:31A7 ( talk) 02:17, 13 May 2013 (UTC)
i. Aluminum chloride, dichloromethane, room temperature, 3 h, ii. 6N hydrochloric acid, reflux, 5 h, iii. Hydroxylamine hydrochloride, ethanol, N,N-diethylenethanamine, reflux, 3 h, iv. Potassium hydroxide, water, reflux, 2 h, v. [[3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one hydrochloride]], potassium iodide, sodium carbonate, N,N-dimethylformamide, 85 - 90 °C, overnight
Preparation of Risperidone is described in US patent 4,804,663 and and also in European Patent EP196132. Accordingly, 1,3-difluorobenzene 1 and 1-acetylpiperidine-4-carbonyl chloride 2 were reacted in presence of aluminum chloride using dichloromethane as solvent at ambient temperature to give [[1-[4-(2,4-difluorobenzoyl)-1-piperidyl]ethanone]] 3. The compound 3 was further hydrolyzed by heating with 6N hydrochloric acid at reflux temperature to give (2,4-difluorophenyl)-(4-piperidyl)methanone 4. Compound 4 was then treated with Hydroxylamine hydrochloride in presence of N,N-diethylenethanamine as base using ethanol as solvent at reflux temperature to give (2,4-difluorophenyl)-(4-piperidyl)methanone oxime 5. Compound 5 on was then cyclized by stirring with potassium hydroxide using water as solvent at reflux temperature resulting in to 6-fluoro-3-(4-piperidyl)-1,2-benzoxazole 6. The final step involves condensation of 6 with [[3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one hydrochloride]] in presence of potassium iodide and sodium carbonate as base using N,N-dimethylformamide as solvent at elevated temperature to afford 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)-1-piperidyl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one also called Risperidone 7.
its the leas potent antipsychotic Qwh ( talk) 10:04, 9 May 2013 (UTC).
Yes in many ways its quite a nice drug, with much less weight gain than Olanzapine, and it gives you a nice little lick when you take each oral tablet, which may help you change town, get a new job, flat or go to college or back to it. Late at night mixed with too much liquor and caffine, ie coffee, red bull it may make you a bit too loud and lippy. More than 1mg a day reduces sperm and with 4mg it will be minimal and 5mg close to zero, but generally this drug actually helps people have good sex. — Preceding unsigned comment added by 60.234.54.147 ( talk) 03:27, 9 September 2014 (UTC)
Innapproiate wording close to disruptive. Also unsorced. Collapsed per guidelines about talk pages, but we could discuss anosmia as a side effect if sources are found. -- Garrondo ( talk) 06:51, 21 May 2013 (UTC)
Posted here to arrive at consensus. Risperidone destroys sense of smell. You can not even smell your own feces or a dirty bathroom after being exposed to this medicine. The danger is you could end up drinking sour milk or go down on a dirty wife who has not washed herself. We have a sense of smell for a reason to protect us and prevent us from eating something rotten or dirty. 2602:306:C518:6C40:F02A:330C:11CC:ACDB ( talk) 06:06, 21 May 2013 (UTC)
What do these receptors, associated with gastric acid secretion, have to do with the nervous system? — Preceding unsigned comment added by 00AgentBond93 ( talk • contribs) 13:05, 14 August 2013 (UTC)
Can anyone chack this edit? I reverted it but am not sure. Super48paul ( talk) 14:09, 22 September 2013 (UTC)
Side effects seem self serving to the drug manufacturer by only listin FDA approval testing side effects. Currently many lawsuits re breast growth in teen boys (gynomastia). [1] [2] [3] [4] [5] [6] Shjacks45 ( talk) 00:06, 27 September 2013 (UTC)
Most of these TV commercials are lawsuits that don't seem to be the honest and complete truth. Where are the links for the lawsuits? 64.113.124.158 ( talk) 23:42, 30 September 2013 (UTC)
References
Could anyone add dysphoria as side effect, and muscle stiffness as they were there earlier? 78.156.109.166 ( talk) 09:18, 24 October 2013 (UTC)
I'm Autistic and I'm irritable. As a matter of fact, I'm pissed. DON'T give Autistic folks drugs!! Autistic brains are fine as they are. We have a right to be "irritable." — Preceding unsigned comment added by 72.70.192.193 ( talk) 06:37, 16 December 2014 (UTC)
need to know
I understand we may have some people who work for J&J who think this isn't an issue but there's plenty of evidence and lawsuits that something is going on and it's clearly being pushed to the sidelines by people who edit this page. I'm not entirely sure why this is happening or why people are choosing to do it, but I'm going to leave this up here until this is settled. If nobody can give me a good reason to refute a federal study and a volume of evidence that there's litigation and the possibility of developing Gynecomastia from taking the drug, then I'm reporting the fact that someone is censoring it. Twice I've made the edit and twice it's been censored and it's apparent that someone doesn't want this going up here. — Preceding unsigned comment added by 108.48.66.91 ( talk) 02:31, 28 February 2018 (UTC)
"In many respects, this medication can be useful as an "acetylcholine release-promoter" similar to gastrointestinal drugs such as metoclopramide and cisapride. " Any sources confirming this statement? what is the difference between "releaser" and "release-promoter" see this -> /info/en/?search=Alpha-2_adrenergic_receptor#Individual Can anybody describe the machanism of this drug which promote acetylcholine release? I mean any proof of that statement— Preceding unsigned comment added by 178.235.88.248 ( talk) 18:38, 11 July 2018 (UTC)
This ref supports the common side effects. Not sure why it was removed?
https://www.drugs.com/monograph/risperidone.html
Doc James ( talk · contribs · email) 03:08, 24 October 2018 (UTC)
The drugs.com link is to the "American Society of Health-System Pharmacists"
You do realize that the medlineplus link https://medlineplus.gov/druginfo/meds/a698019.html is also from the "American Society of Health-System Pharmacists"?
Drugs.com and the NIH have both bought licenses for it. The first is the professional version and the medlineplus one is the patient version. Doc James ( talk · contribs · email) 03:47, 27 October 2018 (UTC)
Galactorrhea and gynecomastia are very common side effects. It should be mentioned in this article because these side effects are said to be rare when taking atypical antipsychotics like risperidone is. As far as I know there have even been lawsuits in the USA because of gynecomastia in young male adolescents. Gynecomastia in males cannot be reversed except by surgery.
Risperidone is even mentioned in wikipedia as "[being] notorious for causing" galactorrhea: "Of these, risperidone is the most notorious for causing this complication." See here: /info/en/?search=Galactorrhea
Source according to this article on wikipedia: Popli, A (March 1998). "Risperidone-induced galactorrhea associated with a prolactin elevation". Ann Clin Psychiatry. 10 (1): 31–3. doi:10.3109/10401239809148815. PMID 9622047. 2001:16B8:C2C3:F400:29C9:AF5:D68:4671 ( talk) 10:44, 14 September 2021 (UTC)
Who actually synthesised this drug first I'm quite interested to know who the chemist responsible for the creation of the compound is and what else they may have created? 103.69.253.9 ( talk) 13:04, 23 November 2021 (UTC)